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pollutants and endocrine disruptors etc., invariably affect body physiology, hence
well-being of the individual. But its genesis and mechanism of effect is not fully
understood and thereby limiting its control. In general, most of the stressors affect
neuroendocrine system but downstream pathways implicated in most of the cases are
of a plastic system that responds to homeostasis and alters its output to meet current
and expected future demands. Stress can alter cognition, memory, cardiovascular
activity, glucose, protein and fat metabolism and hence may affect all the systems of a
vertebrate body. There are some types of stress that have life threatening effects while
other types if continue for a prolong period disturb homeostasis. On the other hand,
some lifesaving drugs may also have adverse effects on different organs and/ or
chemotherapy has adverse effect on germ cells. Similarly, radiation used in nuclear-
medicine has potential adverse effects too. Stress may deleteriously alter hormone
irrespective of its origin alters the output of classical stress hormones (CRH-ACTH-
Corticoids). It has been reported that CRH is the principal regulator of HPA axis.
classic increase in CRH. But how the higher brain centre receives stress input and
what is the mechanism of stress effects/ responses is not yet clear in spite of enormous
responses, the study presented in this thesis investigates how different types of
stressors (environmental, metabolic and neural) affect HPA axis and whether their
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