Scribd Logo
Upload

Welcome to Scribd!

  • 041917

    Uploaded by

    tcd_usa
    13 views4 pages
    Principles of Drug Action 1

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Principles of Drug Action 1

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    13 views4 pages

    041917

    Uploaded by

    tcd_usa
    Principles of Drug Action 1

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    of 4
    Chemical Principles of Drug Action Il - PSCID 1603 Pain Wlanagement: General and Local Anesthetics Dr. RL Chapman Objectives: + Discuss proposed mechanisms af action for general anesthetics at various targets within the excitable membrare of the neuron. ‘© Describe the pharmacokinetic processes of general anesthetic distribution to and from the lunas, the blood ard the brain. «Analyze and describe the pharmacokinetic relationships of a given general anesthetic's patttion coefficient to distibution, the rate of induction into, and the rate of emergence from the state of anesthesia, :: + Analyze and describe the pharmacodynamic_telationship of the minimal alveotar Concentration (MAC) to general anesthetic potency, when given alone or in a mixture. + Describe the metabolic transformations of general anesthetics and thelr relationship to the risk of toxicity ‘Identity, classify and_desc harmacéphores, ‘Explain the mechanism of action of local anesthetics based on the interactions possible between the drug and the sodium ion channel as its target. + Describe the structure-activity_relationships among local anesthetics accounting for activity, duration of acton and cardiotoxicity. ‘+ Describe the major metabolic transformations of local anesthetics. Additional Reading: ‘Foye, Chapter 16, pp. 508-539 physicochemical properties of local_an Introduction: (A> Bosatesi: The lss of sensation, with or without the loss of consciousness, which may be brought onby the administration of one of many types of anesthetic agents, having diverse chemical structure. 2) Senecal anestesia: Loss of al sensations, incluing analgesia and muscle “Telaxation, accomplished successively in 3 stages: f suckon Posy Ly, & stage 4 sage 5 > suri aed <. Anesthesia \G + Pattton coefficients (P), especially: sleet Gee, Porcee, Priewn ieee & Peraisoed oe Minimum Abeolar Concentration (MAG) Volume § V+ Respiratory rate & depth V% Blood flow te the brain Vé Delivery rate & device technology (AD Parition coeticients (P) 2. Pavosous describes solubility of the drug in the blood @®) High Poston = More time required to saturate blood; slow induction ~>Lawy Ponce Less time required to saturate blood; rapid induction: Db. Patooras is related to Porcas (easier to measure) 6. Pree sues and Poansees are equivalent (approximately 1:1). (ok eta kK Inhaled and Ke. Tissues ‘exhaled Aveo slood | <> | including wes | SK, ke L_tetein ee ae Se & distribution mn Coefficients (37°C) fa fort aut as : merass ‘ment 1 Halothand®) | 224 (2.35) Ty Rapid mere rea” a ia ae peaies iu piel? | Sevoturane | 884 (173) os. | Soe ats a | Nitrous Oxide _|1.4 (0.18) Cow) 0.47 (Micat raid? vet ure ny Il. General anesthetics (cont) @ Minimum Aveobr Concentration Macy Volume & ) Sor The concentaton at mosphere fen anestat nthe ae, oqured Tepreluce mmmabity ins0% oad pat ubjeod toa sandard cube een fy Ve MAC is aindetly related to potency, but does NOT equal potency. (/> MACS are aie for anesthe combinations 1/4 (@AC-Awake.- conceiration of anesthetic a which appropiate responses to Vtibal mance ae lst 50% of patents ested a LL s _——_ WV WAC WoIame H Com'tl | roeanese | winattne wine | [it te (NeoanO | Oe ywor a | medorite | Mcthone | 877 0.29168)

    You might also like