Review Headings

4/3/17

Abstract
Keywords (CRISPR, ethics, moratorium, Designer babies, DNA editing, off-target,
mosaic, DNA therapy, chimera, mutations)
Introduction
History of CRISPR (who discovered, where does it come from)
Background info
How it works
Structure?
Importance
Applications
o Social
o Medical
o Ethical
Benefits
Target single gene mutations
Gene therapy in adults
Fix mutations in somatic cells (ex: HIV, cancer)
Huntingtons Disease Reversal
Mitochondrial Mutations (potential to fix)
Animal model (safe, less controversial)
Risks
o Mutations
o Social
o Off target editing in human zygotes
o Ethics in using human germline for research
Regulations
Moratorium
Future Research
Chimeras (rat research)
Reversal of mutations in adult animal