Cetirizine Dihydrochloride

(C21H27CI3N2O3)

Cetirizine dihydrochloride is a potent second-generation histamine H1 antagonist that

is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma.
Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side
effects.Cetirizine was rapidly absorbed with a time to maximum concentration (Tmax) of
approximately 1 hour following oral administration of tablets, chewable tablets or syrup in
adults. Comparable bioavailability was found between the tablet and syrup dosage forms.

Chemical properties

Property Name Property value

Molecular Weight 461.808 g/mol

Hydrogen Bond Donor Count 3

Hydrogen Bond Acceptor Count 5

Rotatable Bond Count 8

Formal Charge 0

Physical properties
- color : crystals from ethanal
- melting point : 110-115 degree celsius
- solubility : In water, 6.96X10+4 mg/L at 25 degree celsius
- vapor pressure : 2.98X10-11 mm Hg at 25 degree celsius
Reference
https://pubchem.ncbi.nlm.nih.gov/compound/Cetirizine_dihydrochloride#section=Top
http://www.sciencedirect.com/science/article/pii/S0731708597002136
NILE 1101