1

(Typical antipsychotics)
Chloprom Matcine, 400 25- 2,000 2-4 30
azine Chlopro -600 200 mg
25 mg metabolism
mazine mg
GPO, mg, 50
Chlorpin mg, CYP2D6
100
mg, drug
 2

200 mg interaction,

(IM) QTc
50 prolongation
mg/2ml (additive
),


alpha1

hypotension,

sedation



 3

Thioridazi Thiomed 200- 150 800 1 21-

ne , 600 mg mg 25 metabolism
Tidazine, 10 mg
Ridazine mg,25
mg, 50 CYP2D6
mg,
100 mg drug
interaction,

QTc
prolongation(


QTc prolong)
Perphena Pername 12-48 8-16 64 mg 1-3 9-12
zine d, mg mg metabolism
Monazin 2
e mg, 4
mg, 8 CYP2D6
 4

mg, 16 CYP3A4
mg
drug
interaction
Pimozide Pizide 8-16 1-2 20 mg 6-8 55
mg mg
1 metabolism
mg, 4 CYP3A4
mg
drug
interaction,

QTc
prolongation(


QTc prolong),


alpha1
 5

hypotension

Trifluoper Trifazine, 15-30 4-10 40 mg 1.5 6 22

azine Trizine, mg mg metabolism
Triozine 1
mg, 5 CYP1A2
mg, 10
mg
drug
interaction,


alpha1

hypotension
Haloperid Halotab, 2-20 2-10 30 mg 2-6 20
ol Halox,Ha mg mg metabolism
lolop
(oral)
0.5 mg,
1 mg, 2 30
 6

mg, 5 (IM) CYP2D6

mg, 10
CYP3A4
mg
drug
(IM)
interaction,
5
mg QTc
prolongation
(additive
)
Flupenthi Fluanxol 3-9 1-3 18 mg 3-8 35
xol mg mg
3 metabolism
mg
CYP2D6
drug
interaction
Zuclopent clopixol 20-40 20 -30 100 4 20
hixol mg mg(or mg
 7

, (oral) al), 50 (oral) (oral), metabolism

25 mg -150 400 36
mg mg/wk
(IM)
(IM) (IM) (oral CYP2D6
clopixol ), 2-3 drug
accuph interaction
ase 50
(IM)
mg/2ml

(Atypical antipsychotics)
Clozapine Clopaze, 150- 25-50 600 2.5 12
Cloril 600 mg mg
25 mg metabolism
mg, CYP1A2
100 mg
drug
interaction,

QTc
 8

prolongation
(additive
),

agranulocyto
sis
monitor CBC

Olanzapin Zyprexa 5 10-30 5-10 40 mg 5-8 30
e zydis, mg, 10 mg mg -38 metabolism
Olapin
mg (oral), CYP1A2
0.25-
(IM) 0.75
10 mg drug

(IM) interaction,

QTc
prolongation
 9

(additive
),


alpha1

hypotension
Quetiapin Seroquel 300- 50 mg 1,200 1.5 6-12
e , 750 mg metabolism
neutapin 25 mg
(oral) CYP3A4
e mg,
100 6

mg, (XL tab)
drug
200
interaction,
mg, 50
mg XR,

300 mg alpha1
XR,

400 mg
XR hypotension.
 10

indication


Risperido Risperda 2-6 1-2 8 mg 1.5 20
ne l 0.5 mg mg metabolism
quicklets mg(quic
, Neuris,
klets), 1
Risperid mg, 2 CYP2D6
one GPO mg drug
interaction,
oral

solution
1mg/ml QTc
in 30 ml prolongation
(additive
 11

),


alpha1

hypotension
Paliperido Invega 6-12 6 mg 12 mg 24 23
ne mg
3mg, 6
mg, 9
mg



Ziprasido Zeldox 120- 40-80 240 6-8 7
ne 40 mg, 160 mg mg
mg
60 mg,
80 mg
,
 12

metabolism

CYP3A4
drug
interaction,

QTc
prolongation(


QT prolong)
Aripiprazo Abilify 10- 10 -15 30 mg 3-5 75
le 30mg mg metabolism
5,
10 mg, CYP2D6
15 mg CYP3A4
1

mg/ml
 13

interactio
n,

indication


(Long acting injectable antipsychotics)
Fluphenaz Fendec 12.5 100 1 7-14
ine -100 mg q 2
Decanoat 25 mg wk 2-4
e mg/ml,
25
mg/ml
in 2 ml
Flupenthi Fluanxol 10 100 3-7 17
xol -50 mg q 2
Decanoat 20 mg wk 2-4
e mg/2ml
 14

Haloperid Halodec 20- 450 7 21

ol 450 mg q 4
Decanoat 50 mg wk 4
e mg/ml,
50 mg
in 2 ml
Risperido Risperda 12.5- 50 mg 28 4-6
ne l Consta 50 q 2 wk
Microsphe 25 mg 2
re mg/vial, ,
37.5
mg/vial
Paliperido Invega 25- 150 13 25-
ne sustenna 150 mg q 4 49
mg wk 4

prefill 150
synring mg
e 75
mg,
100
mg, 100
mg
 15

150 mg
1

(Mood stabilizers)
Lithium Limed, 900- 600 1,800 1-3 24
carbonate Licarb 1,200 -900 mg
Therapeutic
mg mg
300 mg index




maintenance
0.6-1.2
mEq/L
Valproic Depakin 1,200 20 60 2 9-16
acid e, 200 mg mg- mg/kg mg/kg/
Depakin 1,800 /day day () 50-
Chr 125 mg/dl
 16

e ono 500 mg 3-8

chrono,V mg
alpain, 12
(Chrono)
Encorate
,
Encorate
chrono

Carbamaz Panitol, 10-15 400- 1,600 4-5 10-

epine Tegretol, mg/k 600 mg 30
zeptol g/day mg 8-

CR 200 12 mg/dl
mg,
400 mg
Lamotrigi Lamictal, 100- 25-50 400 1-5 25-
ne Lamogin 400 mg mg 33
e 25 mg titration

mg,
100 mg
protocol

 17

SJS TEN
(antidepressants)
Amitriptyli Amitript 50- 50 mg 300 1-5 9-46
ne yline 150 mg metabolism
GPO, mg
Triptyline 10mg, CYP2D6,
25 mg, CYP2C19
50 mg
CYP2C9
drug
interaction
Nortriptyli Norline, 75- 25 mg 150 3-12 16-
ne Ortrip 10 mg, 100 mg 88 metabolism
25 mg mg CYP2D6

drug
interaction
Imipramin Minapine 75- 75 mg 200 1.5-3 6-34
e , 150 mg metabolism
 18

Sermonil mg
10mg, CYP2D6
25 mg,
50 mg CYP3A4
drug
interaction
Clomipra Anafranil 75- 25 mg 250 2-6 20-
mine , Inaryl 150 mg 24
25 mg

mg, 50
mg
Doxepin Sinequa 25- 25 mg 300 1-4 8-36 indication
n 150 mg
mg

25
mg
Mirtazapi Remeron 15-30 15 mg 45 mg 2 20-
ne mg 40
15 GFR<40

mg, 30 ml/min
 19

mg
Trazodone Desirel, 150- 100 600 1-2 6-11 indication
Trazodel 300 mg mg
50 mg
mg,
100 mg

Fluoxetine Fulox, 20-40 20 mg 80 mg 4-8 4-8
Oxetine mg
20 mg, metabolism

20 mg CYP2D6
drug
interaction

CYP2D6,CYP
2C9, CYP3A4
inhibitors

 20

Sertraline Zoloft, 50
50 mg 200 6-8 27
Serlift, 50 mg, -200 mg metabolism
Serta, 100 mg mg
Sertralin
e GPO CYP2D6
drug
interaction

CYP2D6
inhibitors

Fluvoxami Faverin, 50 50 mg 300 2-8 15-

ne Fluvoxin -200 mg 26 CYP1A2,
mg CYP2C9,
50mg,
CYP2C19
100 mg
 21

inhibitors


Paroxetin Seroxat 20-40 20 mg 50 mg 5-7 24-
e mg 31
20 metabolism

mg CYP2D6

CYP2D6
inhibitors


Escitalopr Lexapro 10-20 10 mg 20 mg 5 27-
am mg 32
10 metabolism

mg, 20 CYP2C19
mg
drug
interaction
 22

Venlafaxi Effexor 75- 37.5 225 2 5

ne XR, 225 mg mg , metabolism
Valosine mg 375

SR mg
37.5 ( CYP2D6
mg, 75 severe CYP3A4
mg, depres
150 mg drug
sion)
interaction
Desvenlaf Pristiq 50- 50 mg 100 7.5 11
axine 100 mg
50 mg
mg
Duloxetin Cymbalt 30-60 30 mg 120 6 12
e a mg mg metabolism

CYP1A2

30mg, CYP2D6
60 mg
drug
 23

interaction
Milnacipra Ixel 100- 12.5 300 2-4 6-8
n 200 mg mg
mg
12.5
mg
Bupropion Wellbutri 150 150 300 3 10-
n XL, -300 mg mg 21 seizure
Quomem mg (Europ threshold
150 e)
mg,
450
300 mg mg
,
(USA)
metabolism

CYP2D6
drug
interaction
Tianeptin Stablon 37.5 37.5 1 2.5
e 12.5 mg mg
 24

mg (12.5 (12.5
mg mg
tid) tid) 2

Agomelati Valdoxan 25-50 25 mg 50 mg 1-2 2.3

ne mg
25 mg metabolism
CYP2C9

CYP1A2
drug
interaction
Reboxetin Edronax 4 8-10 4 mg 12 mg 2 13
e mg bid
mg metabolism
CYP3A4

drug
interaction
 25

Benzodiazepines
Diazepam Diazepa 5-15 2-10 30 mg 1.5 20- Active
m GPO mg mg 50 metabolite
2 half-life
0.5
mg,5
100
mg, 10
mg (IM)

10
mg/2ml
Lorazepa Loramed 1-10 2-6 10 mg 2 12.9
m , mg mg
Lorazep, 0.
Lorazin, 5 mg, 1
Ora mg,
2mg
Clonazep Rivotril, 3-6 1-1.5 4 mg , 1-3 19-
am Prenalpri mg mg 20 mg 50
l
(
 26

0.5 mg, Seizure

2 mg )
Clorazepa Tranxene 7.5- 5 mg 90 mg 1 48-
te , cloraze 15 96
mg
5

mg
Medazepa Medazin 5-10 5 mg 60 mg 2-6 5-
m e mg 120
metabolite

5
desmethyldi
mg
azepam
oxazepam

half-life 40-
120
5-15

 27

Chlordiaz Benpine, 15- 300 2 6.6-
epoxide Cozep 100 mg 25
mg indication

10, 25

mg,


5
mg
Midazola Dormicu 7.5- 7.5 20 mg 15-30 2.5
m m 15 mg
15 mg
mg indication

Alprazola Xanax, 0.5-4 0.25- 4 mg 1-2 11.2 XR
m Xanax mg 0.5 (anxiet
XR, mg y)
Anpress 0.25 ,10 mg
mg, 0.5 (panic)
 28

mg, 1
mg
Bromazep Lexotan 6-18 6 mg 60 mg 1-2 20-
am mg 30


1.5 mg,
3 mg

1. Lacy CF, Armstrong LL, Goldman MP, Leonard L.. Drug Information Handbook 17 th ed.
Ohio: American Pharmacists Association ; 2009
2. MICROMEDEX [Database on the internet]. Colorado: Thomson Reuters (Healthcare); c
2012-2013. DRUGDEX Evaluations. Available from:
http://www.micromedexsolutions.com/ Subscription required to view.
3. Stahl SM. Essential Psychopharmacology: The Prescriber's Guide. 3rd edition. New York:
Cambridge University Press, 2009.