1.

Two to 5% of primary renal tumours under 21 years of age

2.Most common renalneoplasm in adults
3.survival for stage 1 disease adter complete resection : 90%
4.survival stage II and III: 50%

Week
0 1 2 3 4 5 6 7 8
C D
D V V E V V V V V
C*

XRT
V- Vincristine 1.5mg/m2 (max 2 mg ) or 0.05 mg/kg
V*- Vincristine 2.0 mg/m2 (max 2 mg) o 0.067 mg/kg
D- Doxorubicin 45 mg /m2 or 1.5mg/kg
C - Cyclophosphamide 440mg/m2/day x 5 days or 14.7 mg/kg/day x 5 days
C* - -Cyclophospamide 440 mg/m2/ day x 3 days or 14.7mg/kg/day x 3 days
E - Etoposide 100mg/m2/day x 5 days or 33 mg/kg/day x 5 days

Fig.19-3, Clear-cell carcinoma stage I-IV .(Modified from Pizzo PA, Poplack DG, editors, Principles and
Practice of Pediatric Oncology. 4th ed. Philadelphia: Lippincott Wilkins & Williams, 2002. )
 9 10 11 12 13 14 15 16 17 18
C D C D
E V V V* V* E C*
C* C*
19 20 21 22 23 24
C D
E V*
C*