if you change the message attribute for these 2 messages to error, then it should not be

possible to change the quantity anymore:

06076 "Materials of requisition & item & alr. ordered in full"

Default: Warning message

06400 "Materials/services for requisition & & already ordered with & &"

Default: no message

Check the Field status for PR --> AKTV & ME52.

Change the status as display mode.

We had also faced same problem in our organization 2 years back. Then I have change the
screenlayout of ME52N as follows.

SPRO -> Materials Management -> Purchasing - > Purchase Requistion -> Define screeen
layout at document level -> Create new entry ME52N by coping ME52. Then goto qty &
price field, tick the Qty field as display.

Due to this changes in PR Qty in ME52N will not be possible. If any change in PR QTY
before creation of PO has to be done then user has to delete that line item in ME52N & create
new line item in same PR.