.

, MBBS, MD(Pediatrics),
,
.

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 Dr. A. Arunkumar & 2




?

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 ?

Fatty ?

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PUFA?
MUFA?

LDL?
HDL?

TRIGLYCERIDE?

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!

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Lipids / fats
.
( ,
)


.

.

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10 -
50%

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Adipose tissue
- adipose tissue
10-50%
?

2
Peripheral fat
Visceral fat

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 Dr. A. Arunkumar & 10

Triglycerides 98%.


.

wax

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Triglyceride

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Saturated fats

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Unsaturated fats

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 PUFA
3
ALA , FLAX

EPA, DHA

6 , , ,
MUFA
7 ,
9 , . ,
, , ,

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Trans fats

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, ,

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.

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?


.
30%
( )

.

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 ?
.
, A,
D, E K
.
D
, ,
, ,
,
.
.

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 ?
1000 2000 - .

?
300-400 .

?
37
.

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, , .
.
.

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 -
.
- 2000 2500
1800 2200

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 Dr. A. Arunkumar & 25


, ,
, ,

.
.

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Obesity

Dr. A. Arunkumar & 28

 Dr. A. Arunkumar & 29
 Obesity: A Chronic Metabolic
disease Dyslipidemia
Hypertension
Lipoprotein lipase
Inflammation Angiotensinogen
IL-6
Insulin Premature
CRP Ageing
FFA
IGF-1
Cancer Resistin
TNF
Leptin Insulin
Adipsin
(Complement D) Lactate Resistance

Atherosclerosis Plasminogen
Adiponectin activator inhibitor-1 Type
2 diabetes
Metabolic Syndrome
Thrombosis
Dr.
LyonA. Arunkumar
CJ et &2003;144:2195-200;
al. Endocrinology Trayhurn

P et al. Br Eckel RH et al. Lancet 2005;365:1415-28.
J Nutr 2004;92:347-55; 30
 Dr. A. Arunkumar & 31
 Dr. A. Arunkumar & 32


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Atherosclerosis

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Atherosclerosis

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200
.
L(p)a Homocysteine


Uric Acid CRP
D




AND. . .

Dr. A. Arunkumar & 36
 Dr. A. Arunkumar & 37
 -
saturated ,

The
Diet-Heart
Theory

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Ancel
Keys:
Six-
Country
Study

Journal of Mount
Sinai Hospital 20,
118-139, 1953.

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All
Countries

New York State Journal of

Medicine 2343-2354, 1957.

Dr. A. Arunkumar & 40

Country
Pairs

150=3.9
200=5.1
250=6.5

Keys. Circulation 41,

suppl 1, 1-211, 1970.

Dr. A. Arunkumar & 41

MONICA
Study

150=3.9
200=5.1
250=6.5

Dr. A. Arunkumar & 42

 Dr. A. Arunkumar & 43
 Dr. A. Arunkumar & 44
 Lipitor Ad

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.
???

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(15 )

1%
, 11%
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?
, ,
,

, ,
sensitivity

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 Dr. A. Arunkumar & 49
 Dr. A. Arunkumar & 50





effect

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sensitivity

AGE

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Ldl in

triglycerides
hdl
inflammation ( )
, metabolic

6:3

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( , , IGF)


PCOD .



...

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?

, Ldl
?

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?

Saturated ?

Pufa ?
Dr. A. Arunkumar & 56
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 Dr. A. Arunkumar & 59
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 Dr. A. Arunkumar & 63
 Dr. A. Arunkumar & 64
 Dr. A. Arunkumar & 65
 Dr. A. Arunkumar & 66
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 30
, BP ,
, 5 . ,
, !!!
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 Dr. A. Arunkumar & 70