Peritonitis and Abdominal Sepsis Clinical There's something ‘you should know Presentation «B® © [eos Histor Cieon 7 Tre deg pron sy acd son sos ine een re pominal surgery presousesoces cf penis reve sty use of Recommended immunoappressive spent, andthe presexe of dss, lanmaty toved Heoy deez, avril pep cer sas) that may reispose to neabdeminal AEE incon, i nana Pedic Seb Ennion Abra! rege of sis and mpc ae seni sporzncus toc pets (5B A ic ino of sgn mise arn wen ang pt th + Sowa asc patty ese wih ace cal elon. Ae many es 308 osaisssaccnonons ers are comply esmptnatc Mn of BP ray inch the cid Seon 0% ‘eons oop + Feet nls may es UK ofp + Abdi ain cr dscoro foun ins ran as 7% of pas) Teste + Hrserng or unoxpne encephaopaty poral + DlantesYoke etaesen we OO cs Dees + ses th oes npr flovng aint of utc een + Mlosang one onset ren ae tes [Abdi pan wich ay be ce rinses ste usu ie corn of ents wth peices. ly he pain ell an py cae sce eoneun) oe, progeses to tay sree an mere cle a pital ‘eoneun).Abcominl psnmay be exceed by amy mover eg. cousting, ‘eg tise cal ress te ncn groces not ceeanes he ain beceres ie In cern dlsease eres fe, ps pete sete cute parce sine cherie the ebforina pain be geneezes tem ‘tobe, _Abdoninl inten nay be noe, wala go etic fa xa, ‘Sympiomsmy bse n pans on ocestacesnclbae pats ith stance nerepty era opie paris copecay He vey young ene ‘te vay od ne presence of aces, cecreases con neteen Revco ict pete sutaces ay rece espns bee laa een ents wih EP Antes encase ete spon may pede ie eve scrip ering ray be eo unc vicer organ ethology fe, eter) rb secondo pester, Paste Sense Bac Sepss 7 pen your Medscape invitations foraquckway Physical Eaination ‘On pyscl earinaion, peters wih pests geet apes uel nda aie cites. May heme = erperate fet oceets 38°C etheugh ater th severe spe may become hype Tetycarde may be presen asa sufi leas of tanner meds, tevascula polo oe veriing an fees anid pace ssi the anne cavity. it _rogressveceytoon pes my becom hypoth Nope) es el es ogutc au wth severe pron, Ney my presen overt sete shock When oainig te shorn of pant wih suspected pais he ptt ul be sii. Arlo owe uname epee nes may allow tr te rele of the abril vl ‘nbc ir te el prs enc eds psn nose ese hence ati re sovee tise bien phe pot asa ede eee tenes rey ovis te ple noes ee se onan pte er, Nespas ceonsate rece obi wal gy. ences a terial al ruc tee may be von, nage to ccnp ‘he eb xen, or uch because ofthe pertenesl ton Peri th evre pions ote aed al maton nd ke elie fled rele the acon! wal tein. The eben on sere, vth Iypoeclvescabsent hovel sous. Ths cag ees a genered Hes rd maybe presen he infection wel lacie. Occsonsy he acme xenon reek en iarenon mess, ‘Sins hepa ele eg jam, engine maybe nce.Fc exarinaon cn es increased bonita pi pty wih infront pic ngs bute ndcteso spc dns. tener infrmtrymes tvee teghmay nel pends, nds ‘less ‘and fctustion may indicate a cul de sac abscess, Infr en’s, van acinar fncingsmey be consent ‘th eke imatyczaseo,enchmetis sepingoonphrtis caren bec bu exam ncngs ae of cco repein ever paras ‘cone phys earn ngs exc cents ase fresensonng xen of pets, Toc processes wih Cophegnaicinion ,empyensexapertonesprocese ryelnehts, ys, sexta ed eboina wel processes, info, recs etna) may nic erin sand mpi of pants. ‘Yeas xan the plete presence of tema hes nde cuted ineacerton emernber het the presentation andthe ncings on clinical examination may be corey icone orwell npr wi icant inruncsuppresion (eg severe debe, seri we postenepont sos HY fect in pets tlie meni leary ac enceelope ec hak, analgesic agents n pate wt paraplegia, nd in patents of advanced age With Ice dep peroneal nections eer nr anced WBC county be ‘realy sigs reser Asrenyas 20% pte wth EP deransesvexy sie onsen ynplars. New one ction ong encephooey maybe the only sin ofthe invecton atthe ial presentation Mest piers wh ‘ubercous pero demonstate vague mos and may be el,Jigar sraony Patoshaotey Bohoy tent rages Peerttavanon Background Peston ned es an intention tthe srs entre ht nese aden cay an the gs cores here The eso, ich an thn sete evtcaren acs vais aks thy wom inienmiry espense Depending on fe unig page rest pets may be nections ose fe cheika ermecharica te atonal epsisisan tna of he pecneum cased ptageic irae et duc Thoma proces maybe ed betes or use rate See Peptic) esc oe cane cdc of enicton to he ese Ste sone encanto rgan erat ia ako es fo ects, suas oon toes, be tom apr al ects leet verge am aparece Women ao eer eae peti for ence lpn tute rapes vnc, ese ray rest wih zu cus eno mpm ite nd ese of steric andsovere ceose wh sep sock See Ele] ‘Pestoneal infecbons are classified as primary fe, fom hematogenous cisseminetion, sn sein oan irmuocenpetsa) second fe ee = eileen vse gn chs efron oma sng ‘strogenic Trauma) or teriary de persistent of recurrent infection ater edequate ‘ntl therapy). Primary peritonitis is most often spontaneous bacterial psitonis £29 senshi th chon er dss Secon etsy ‘at the most common form of peritonitis encountered in clinical practice, Terry ‘Pettonits ofen develops in the absence ofthe orginal visceral organ pathology. Det wa ennemesoptrs ndepeteegisfon haar Baad Recommended Pedic Sopa | oseassacenarons Bact Sepss ‘or aqickway {ofp roeIocved fico bcs This atic oases cn ihe dag a rangement feces pron nc abemmal asses. Anabel bce seen na nap al, Aasyesan nnymarenyctoom see receme iponaniveiynberghncenninfnede tua ena Sipe mnmetnntleningue cartoons “The clegnos pert usualy cal Diego pertanellerae maybe hain who donethave conch ss on pysal exanaon or ‘io cm previ an adorn con, paar shouldbe evened al patents who donothav an ndwengpetenal cetera are -uspecte of bang SEP, becouse recut toi and esc acl cars used incrnicon wh ihe elcome wefan gui heey. See orp) The cent approach patos and peroneal abscess tages carecton of ‘re mcerhing process, arisen oc nbs, nc suppor ‘heey preven ort secondary compktons ce orn se ee, (See Teament ene Mnagement ond etisen} ay conch etc sources acon ae con baie peril end enceraey. Nonoperai itervetns nue pecunecus ces cage, a wells prculnccs andes interes. Opie manage kesh nef contl telafeous sue ae urges ‘oxi The pe and cent cf sugery pens on hunch dase process anche eset ofan inecion, ‘oraquckay ‘alg int ne prodtinnaton fromindstyAnatomy Te peter e gesaed os compl serous marbrane he body tess sa cocky ing th ise oe ssn val rior note. ty oi the bunds he esopertoneum poste oy vein e extaprinea suc ne pls ra an by cavcng the mctsueo he crhagm up) Tis paral layer the erie feels onthe ami vicerl ergo om Be cera peso thc rates potent space ate be 2 lees, pt ne ey The ptencun crs ease yer Matened esta eal over ese nel sue. The ese comecive Ss yer cea aich etre vascular empha elles, eee cnngs ahd mun compete cel, patel Iynghocyes nc ecrophoges. The ens sare ces xe ones by unc empl, ong trang membrane tet aks cage ch ent cota srl sluts Pcyo acy ofthe mesotall el en pagacres by mscrphoges alee the eaence ofracremolecls. Nome mount of pened ereset ess han SO ml, ney na ‘lunes are nse acs re cansloerabe saeco ares na teaoy ste each ay. The pricneal id eres sma urate, wih coc nS encentatas st tanking teste spaces ne tela content sflese then 30 play oun nase, pete Mas ces se ruber: descnontes mesonelel els andvaus runters an merhokges ofigzing immune cls feterence rages 200 calls pesominanty oF oneuclr espeleg The petal coy sides Incarplyhio cmparrets bythe mesentte stocmens and secon reopertcneslasion cer vice pans, AGEflee than 30g, manly burn neon, pence id coi smal bers fescue meshes end vous mbes endmomlogis cf iging mune ces feferencerngeis 30 cele Leste cf rneneruea merely ‘The peroneal cnt ced Invent crpaensy the mec facets andsecentaryrezopertonealen of ean coer Age atonal the gener omen, evens fo he geste une ofthe siomach an eter sgt oe prime duodenum coward ver 8 Vette cence kup sth sen othe eran ascends backtohe tances othe tenses cok. This ern s ernst sty een niroscopic anon wh neste sutoce eel ene ge ue of espoyts,rphoctes end macrophages a “unconss ft stroge cation end moe nme agen The cnparienseaten fhe parton ayn concen wth he eater corti neces the clas a seat of poe anmaton ac eco, Pathophysiology Ines caused baci, eps espn seein by seve ‘eclorsncng the vilence othe continent fe se of henccuu he ‘rune stu and eer het fe os eg. ance he cute Physica nd Cwonic Heath vac APACHE score. ac eres of fe lecal enorme sch as nected, re, Irene sep tom pares sus secon peas or supp pet ess om cect loge of hr contens thePethoonysiology In pestis casey beter, epson responce i cetines by sever ‘acre the vec te cnet, he size fe noua, he Inmune sis anc over het ofthe ot (og es indeed by he Ace Philo one Geni eat Even I APRCHE Hor and eames he -eealemenment sch 5 nerd sue, lod ore. nreabeomina eps fom operate cs, econ pero ot ‘supurte petniis rts fom dct lle lumina contents rc he patonea eg, prtaes ppl ules vertu xpenics aogenic efron ith the page of he certs. gram ngeve and enero acl lncusng crinen gira, sch as scree co en Kee neuro, ce the peroneal cv Ene precucedty gamete boc edo ‘heel of yest duce eB nae cascades, resin cellar davape etc shock andmulipe agan dtc gore NODS. Te mechan ‘or bat neuen aces es heen a seco much bee sine Harold Com frst recogtzed tin the 1960s. Ene omganssane ‘racy been lee fom mare hen SO cineca ase n senioneus bata pent EP) suggesing hth Gets serce of bcd cenannaton. The pepenseance of ent organs ncn ‘th he presence of econ in ascc endloed, oncefevred fe xguent ‘hat SP wis do fo ect tersmural migration oat tom an instal or oe otgn rena peromen caleba ansecson. Howse, agent evisencesugess the ec ensmutl mien cf mireorganis might the case of EP‘a leat popes mechs for bac roc of ascles age femeogennsscuce of he icing ago incontinent nirpted Inmuneceferse sen, Novthls,eenct mechan otal éyiaceret che tno sis id reese source cf much debe, _Ahos{ offic conituis inthe faa of prone infenmaonand bacteril growth in the asc id. hey predsposng factor may beth intestine tect ergot four peopl wh cis, may atten to decreased tsi tense. ese bat overran wth inpsed pogo ‘unico, ow eum an xcs corplement eas, anccecreasd ache reicdoendohell ste, conus bo an nceased munber of mirogarisns nc ecrevedcopecty oe them om the odsreen, esutng ter ign nt arent lean vin aces a, bites cus wh SB yal haves bt ms cen wth SBP co net have aces. The eso fr ancmechens being isi he soure cgi hesigaton, Flora Aron fos rough nrease asmnagen act tract) and th procuctn off exces have ninpotent ron pers The Procucenf rin outs en importa prot i et etn bt ge umber of taint maye sequested wn he sa mate. Tray systemic sein ofinteptined econ ancmey dese ext moaty res tom se but ae sgl the developmen oresua Weton and abscess maton As the fin malicrtres he bac itn ae plied ‘tom test cesroce nears,tse frmaon A eS mae nas he acer hin oreo ‘ore ere mechan, ‘Whee Sen wnt resusn cnthentor pert icon may cap ch dee of pate ec eterno eine SSE. ES ictal eto: tht examines heeft cts cetbmosenatn an ‘tose of oral en bere hay etna certain eo set parte wn ey des 48 cae orci eK Bacteral lose Beco nd then cine petogen ao ey inpraroes. Some suis suggest me i uber of baci presen eine asa cr abeorna econ iru ie en aly beeved opeodrety 2 0 CFU, muh hiher fen te 5 «0 CFL nc one use er ro suscep lesing) This acl may overs he cl es tense, Bactealvitence Bact vlece ers nee wih shoe ene wth neni mete ace ng ede the prisncec fete anc abscess ‘ema, cnong se vce oe ape ran, eave serbic crowth cheson cpa nd suction Syne betecen cen oii and fungal xanssmay ao pay an pect ln retng te hast etn. One such sya ay ev eaten Bats fap ndcamnegatve bee partly Ecole erage been, here colpeuan Seances bie pceson and abscess oan,Enterococd Frtrcctinaybe inp ebercg he soy pec? period infecions, henimel models operons wh Ecovend 2 fags the sysienic raisons ofthe pattoneal fection end bacteemiaates were Increased, as were baci concertos in he peroneal uid and ree of abscess formation. Neveriles, fe ile of Enterococcus ogarirsin Uuicompkcted ine cbdorind infections remain uncdeaAntots ht ck ‘speci aiy against Erixococcus ate oTen used succesfully inte therapy of Dern and he organism isnot fen recovered as Dood bome pathogen in intoatdonrl sis Fung) ‘The ele fun in the forsin ofa bdomind abscesses i ct ily unersted, Some ars suger and fing ss engrergiic erties wihincomplée competion alouing then cogs is sting beret othe batt cin erga a ‘ergy of ugh hich may coriiote fo increased morbicy,Abscess fomaton Abscess faton ccs won te est eens sneer th vecting ‘enacts o cel the sresd of is getty crpatestazeton Ts recess ede tye combnaono ets ht share acoran eat, ingen peace kling Most rinal ensue sues sugpestt ebecessfamaton ccs ony fhe presence of abcess pening agen. Aough tte ree nd spectum ofthese fects heve not been ued teu cere egies eg be ence contents of ule sta hve been ideas cbcessgeemtng ages. Wendel, hese arrs ini epsrton end phagocyte by meence wth compet acticion Cytokines Te oly in he econ of he born espns nd hl le inte cevdcpn oh strana espns yc SRS) and ude cag are MOF Reve ean a ares of resech vet he pst eed Compas fe dita ci cout he agit of he Innapetcnestnsces ttn spose aires te ost sg cet sug tt ace prs ese wen nee epee comptes cre espe Hier el of cen yes fe. mor recta acta TNF aber Reve been ascites wt se ators, 5 ela secede uncenle) acaten ofRe steric Ineo csc,Etiology The tay of se depen one yp, swe sean of pa ‘alos: 4 Pima pets «Seconda pertonds + Tesi partis + Chena pris + Pestana tess Primary petonits Sponancous bt pron SEP} an ect bec neton fc Connon cf he prone cast fought tention of bic acts ut al ermeseni phe nd ess ee henatogencusseedngin the pesencecfhectrria ‘BP om accu es a complcetn of ery deve seh roe the cia ‘nctme of ass, sichas heat eh ene Buk yncrone Cre th nephritis enyretoss te vests tae nigh kot evloig SBP The ies i SP, nes pein wth ces oo ‘seina decomperscied ste npc, ceressed hepatic ye uct ih soca toll prone oe compete of robnged roterin tne Py ssc wth raxirun ek as th ein evn asic uh aval ihe ik ling SEP than ‘tos witha poten ee eter hen gle. Appoint 0 pate ahSpontaneous baci pets SEP) en eu bettie fect, Conan oe pene ays thao es a enstcton of baci acts hg el mas rls nese Maguay, a hemstogenou seed he pesance often SAP can oc as. cempkcten of my ease ate produces the ccd ‘mame tects, sacha ee alo ea Buss Clan erm Cire wth neh ttc ps eryienaozs io ave ces havea igh ik cf ‘evecrng SE. The ish kof SEP however is pate wih cos eho bie ns econ sas geriut,ceeased eps mec ftom ih exciton eve ecole ees, of oases edvembin ave PT) sects win nau ok abe wh en pth eves in acc hig 1 ge ave igh ko eveleng SEP en ‘hose i ec ke! ei thn Apron 10:90 opens wth tits nasi evel SP. Tendencies io mote en AO th ssi prin coments less an gi le ccs Bo pa, resume becese of eres eee a psn acti, Nore nen 0 ofcses SH re casey a enero, Ie mest ‘onmon pahogansincde gem agate xan, Eco 0) K enone), Peuctmoasipeces, Prous pecs, her ger-egatie secs 20% en a sve orm , Seococas reumon (HD ther Stopococcus species 15, and Syococes species BND ee Tete ower some ta suggest hatha parentage fram posta vetoes maybe crn. oe sy cee «31.2% ence enetcocl eng secon tien ter Exerobectacee" Vindare up epcocel WES) ecco for 73% ofthese spice oes Ange cg sce In 92% of, nb cee ae pia, Secondary pero Common eles of secncey pra Pcs peresee pence petted gece or cere cer per fl colon caused ty ets, avs or cece and sanguin o fe srl bel Be le ‘4 Neco peers cen aa be sce wth patina of inecln othe necro se The pahegen riled in SP rin the perl ne cd Get Gem postive cgi predominate in te upper trac wh ac ove greece cages ie upper etn psn’ en og cesta supresshe ‘tere Centurion tom a stl sel vel cok source tilly ray test Inthe eles feral antes bai pies fd fg est ef culty cline st ofthese ergs: Te renting restos anos ales emir coning emi cf erotic anaerobic htt wh [edannce fam gave xganans ee Ele As ny 25 16% opens who hav os theses who wee intily sued have SEP hay SP nmany ofthese pts, cnc ns ene ‘mts lr axe a sent rpc encugh ely cet beter ie 2 ene Atreroug soy evn othe penal end tioned gostei re nce do soa ighinc of suspic segue. Tile Corman Cust Second Pars Ope alein ane ince)Table Common Causes of Secondary Pertoits « Bock tasietora [> Table Common Causes of Secondary Pitot € ecctoList, Teale of 4 Table. Common Causes of Secondary Partontis < oaktit aTable 1 Common Causes of Secondary Patents € BecetoList pie tof 4 & Beckto ble tof 4 Table Common Causes of Secondary PertonitsTable 1, Common Causes of Secondary Peters < deektouist entero [> Table 1 Common Causes of Secondary Patents Table, Common Couses of Secondary PertonisTablet Common Causes of Secondary Pesitonts ¢ deeetoList table rots [> Tablet Common Cause of Secondary Peston < BeccwoList, Teolevore [> Table Common Causes of Secondary PeitoritsTable Common Causes of Secondary Pests ¢ deeetoList tevierots [> Table Common Causes of Secondary Peni Table. Common Causes of Secandayy Pastors < deektouist entero [>Table 1 Common Causes of Secondary Pertonits Table 1. Common Causes of Secondary Potent Table 1. Commen Causes of Secondary Peto < acetals Teble tot 4‘Tertary pertonits “tay pets ee Tite 2 beow devs mre enn inmunocon rie pees ann pasos wih sic pessing corr onions. Atcha cseredin compl peed ein te inden otra patti ptt reping KU ts te sere coal icone es igh 50.78% Tibaos prei rein he Uni Sikes (28 ofl cae of esi lone abe sence pe in deveoig canis nd cr prs when inmunceiiency vs ic, Te rsering gmp fen nenspetc ninsousinocelg.vgrde ee, sei wits) Mey pew Phang oss Moe en 5 o pew have erence ses on ing sas avd aren het septs ve dic apt ai, Innstcses chested ds pans ih TP proce bruce plronay Sexes corman {30} Pecuts on Ga siin ct cet id ae rey pst nda ests ay be ely eget inp ‘peers. Apron ud pric eel grein 25 gd, late cehytogerese (DH ee ger fen 90 Ul, or pretninenymonocesr celcout of get hn ele sd ude Tate id spe he dens gsc andvilzion ganda cn esnips, as els cues eres 45 v8 nye ested ‘ote cetibe dns ower en ea sl begh mee