File: Vitamina D3 Blin

Antecedentes:

Hace algunas semanas se presentaron problemas con Calcio + Vit D3: Al validar el tiempo de
estabilidad

La vitamina D no se distribua de manera homognea

Se encontr que el 100%de la vitamina D se degradaba en 45 das.

Con el objeto de resolver el problema Ulises hizo lo siguiente:

1. Para resolver el problema de Distribucin emple el procedimiento por diluciones.

2. Para resolver el problema de degradacin, que muy probablemente se deba a oxidacin.
La vitamina D se degrada en presencia de Oxgeno,
Disolver la vit. D en Etanol
Aadir Sorbitol+ Butil Hidroxi Anisol + Cremophor

Frmula

Nombre: Vitamina D3, Colecalciferol 10 - Secocholesta-5, 7, 10 (19) - trien-3-ol

(3.beta. , ol, 7E) - 9
9,10 - secocholesta-5, 7, 10 (19) - trien-3 -
beta-ol
7-dehydrocholestrol, activated
7, 10 (19) - trien-3-ol, (3 beta, between the
parties hereto, 7e) - 10-secocholesta-5
7, 10 (19) - trien - 3-ol (3beta, between the
parties hereto, 7e) - 10-secocholesta-5
activated 7-dehydrocholesterol

CAS No. 18 th-97-0

Categora Secoesteroide

Solubilidad: Etanol, ter, acetona, cloroformo y aceite

vegetal. Insoluble en agua.

Peso Molecular 384.65

File: Vitamina D3 Blin

Mecanismo de accin

Metabolismo

Excrecin

Vida media

Indicaciones for rickets, osteomalacia and baby

tetany, rickets both dental caries may also
blindness prevention. Large doses for the
skin tuberculosis, skin and mucous
membranes, such as various types of
lupus erythematosus

Dosis Injection : 150,000 u/0.5ml : 300,000 u/1ml;

U/1ml 600,000.

400 IU/day, and the tolerable upper intake

is set at 2000 IU/day, although a recent
study suggested that this upper limit could
safely be increased to 10 000 IU/day.

Efectos secundarios lot of vitamins, such as long to 10 people a day

to 15 million units, can cause high blood
calcium, loss of appetite, vomiting, diarrhea.
After which the soft tissues such as kidney,
bone and other abnormal calcification. If
impaired renal function, there will be more
urine, proteinuria and renal dysfunction, etc..

Interacciones

Observaciones

Vitamin D is the main function of calcium; The phosphorus metabolism, the difficulties calcium;
Phosphorus absorption and bone calcification. The lack of human D, calcium absorption; The ability to
reduce phosphorus, serum calcium; Phosphorus levels decline, calcium; No phosphorus in bone tissue
deposition, or even bone salt will dissolve, Yam confines of the bone calcification. Children were in the
lack of rickets, while in adult bone softening disease.
File: Vitamina D3 Blin

Frmula

Nombre

CAS No.

Categora

Peso Molecular

Mecanismo de accin

Metabolismo

Excrecin

Vida media

Indicaciones

Dosis

Efectos secundarios

Interacciones

Observaciones
File: Vitamina D3 Blin

Frmula

Nombre

CAS No.

Categora

Peso Molecular

Mecanismo de accin

Metabolismo

Excrecin

Vida media

Indicaciones

Dosis

Efectos secundarios

Interacciones

Observaciones

Referencias:

1. Zhu, G.-D and Okamura, W.H. Synthesis of vitamin D (calciferol). Chem. Rev. 95:1877-1952
(1995).
2. Ikekawa, N. and Ishizuka, S. Molecular structure and biological activity of vitamin D
metabolites and their analogs. In: Molecular Structure and Biological Activity of Steroids.
Boca Raton: CRC Press, pp. 293-316 (1993).
3. Calverley, M.J. and Jones, G. Vitamin D. In: Antitumor Steroids, edited by Blickenstaff, R.T.
San Diego: Academic Press, pp. 193-270 (1992).
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4. Crowfoot-Hodgkin, D., Webster, M.S. and Dunitz, J.D. Structure of Calciferol. Chem.
Industry 1148-1149 (1957).