Synthesis

Organic

masruri
Organic Chemistry Lab.
www.masrurichemistry.lecture.ub.ac.id
Email: masruri@ub.ac.id, masruri123@gmail.com

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outline
IntroducEon
Retrosynthesis
ProtecEng Group Strategy

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introducEon

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Retrosynthesis by FuncEonal Group
Interconversion (FGI)

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Choice of reagent

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Retrosynthesis by disconnecEon

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example

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Strategi melakukan retro-sintesis
Start with reasonable starEng materials and
reagens
Propose a reacEon with a reasonable reacEon
mechanism
Strive for disconnecEons that lead to the
greatest simplicaEon.

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Example:

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Strategi melalui penggunaan gugus
pemroteksi (protecEng group)

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PG for aldehyde and keton

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PG for alcohol

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PG for alcohol

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PG for alcohol

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PG for alcohol

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Ester PG for alcohol

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Acetal PG for alcohol

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Acetal PG for alcohol

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PG for ester

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PG for amine

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PG for amine

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PG for amine

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LaEhan soal
Prediksi produk dari reaksi jika seEap reagen disamping kanan (a-e) direaksikan
secara berurutan terhadap molekul disamping kiri

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LaEhan soal
Prediksi kondisi yang bagaimana agar dihasilkan A secara dominan, dan B secara
dominan jika PG yang digunakan seperE dibawah. See reacEvity of de-protecEon
reagent on www.organic-chemistry.org/protecEnggroup/

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Prediksi
tahapan untuk
mendapatkan
produk
disebelah
kanan.
Termasuk
kemungkinan
menggunakan
PG.

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LaEhan soal

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