AGaxanup/Jlammeyaun Cantos (CHYHAJIHA KAPTA 3A (6anetepua onaxonia # Gyraaxa) CTRAHAL Hocere rasw kapra nocronmuo ¢ Bac ‘Toit earo AGaxanup/Jiaxcusyaen Cantos costspaca aSaxannp, HAKOM MaNVeHTH, KOWTO NpHEMET ASaxannp/Janusy mun Caraos, Monke fla Noy'ar peaKUMa Ha CBPEXYYECTBHTEAHOCT (Cepuoana anepriia peaxumis), KONTO Mowe fa GuuNe ONACHA 38 AKHBOTA, AKO TIPONAOAH nevenneto ¢ AGakabup/JIamupynun Casiz03. HE3ABABHO YBEOMETE BALMS JIEKAP, xoliro me Bu noceneroa gaan na enpere npwema ua AGaxapup/JIammeyaun Cannoo, axo: 1) noayanre xoxen o6pan FUDL 2) ce noma equn nam noseve cHmuToMH oF uaii-manko JIBE or enenuure rpyaa ~ — BHcoKa TeMmepatypa, + SanyX, puanateHo repo wt KauuTAA + raewe, mospomane, apy, wm Goma » KopeMa = caumna ywopa, Goma 1H HyBcrBo Ha 610 HepeanonoxeHe ‘Axo cre cnpesim mpwema #a AGaxasup/JTamusyame Catiioa nopani npoasa 1a Takasa peaks, HKOFA HE TPSIBBA JIA TIPHEMATE AGaxasup/JTaunnyaun Cangos win apyro sekapeTs0, comppxamo aGaxannp (wan. 3naren, Tpranenp, Tprydek), Tol K2TO R paMKHTe a YACOBE MOXE 7a ACTEMH OmtacHO 3a ACHBOTA NOMIDKABAHE HA KPEBHOTO HALITaNe WH CMBPT. (ox. o6parmara crpana na kaprara) CTPAHA2 TpxGea HesaGasno na ce cBspsxere c Balms siekap ako MMCIIMTe, He pasRMRETe Peak a coppx4yscTanTemHocT KbM AGakasHp/Jlanmpynun Cannos. Hannmere no-n0ny Aannure na Baus nexyeaul reap: Tlexap:. Axo He Moxere 1a ce eEEpweTe ¢ HeKYBaUlna eKap, KesaGaBHO MOTEpeeTe Apyra MequumtcKa nomom (usBuKaifre anHeliica HsM oTHKeTe B Hali-GrmaKaTa GoAHEIA), O6ma mpopmamns sa ASaxasnp/Tamnsyann Cariios Moxe fa nonyunre Or: TH Cangos a4 Bearapas 02 9704747Acros: am opmanus 5a n ASaxapup/JIamunyann Canzos 600 mg/300 ‘Abacavir/Lamivudine Sandoz 600 mg/300 - aGaxasnp/namusyav (abacavir/lamivudine) Mpouerere saumaretuo nanaTa AHCTOBEA, UpENM a 3ANOUNETE [1A NPHEMATE TOBA NeKAPCTBO, ‘hil kato Ta chaRpaa naxna sa Bac nugopManus. ~ Sanasere Tasi anctoska. Moxxe sa ce HaIOxK 1a & nMpoNerere OTHOBO. - Ako mare HaxaxsM aombaHuTemn Bsmpoce, Tontrafire Baumia seKap 1mm bapmauest. - Toba nexapereo ¢ npearucario sueio wa Bac. He ro npeotcremsaiire wa ApyrH xopa. To Moxe a WM HaBpeau, HesABHCHMO Ye MpHBHAMTe Ha TAXHOTO saGoRABaHE ca CEUMHTe KATO BaumHTe. + Axo nonysuTe Hekaxe HexecAHH eKapcTBEHH peakluaH, yseaomere Baltits neKap HK ‘bapmauesr. Tosa BKMOYBA H BCHYKH BEIMOKHM HEMENAHH PeAKUM, HEONMCEETH B TASH suctosxa. Broxre ToaKa 4, BAXKHO— Peaxunu ua capexsyncrontenuoct AGaxasmp/Jlammeyann Canios enrspaca aGaxapup (axuBHo BeUIeCTBO CEO 8 eKApCTEA, karo Tpasmoup, Tpaymex 4 3aren). Haxou naunenri, xouTo npewat a6aKkaBHp, Moe 18 PABHAT peakuna Ha cBPEXYyBCTEMTe-HOCT (cepHOsHA aneprvsta PeaKUIMs), KOTO MODE 1A ‘Sue sKuBoTooacrpamaBallla, AKO NPONsUKAT a NpMeMaT sleKapcTaa, ChITbpIKAllIM aGAKABM. ‘TpaGea suuMaTesno 4a mpouerere NanaTa ANopManUA B TOUKA ,PeaknHA Ha esphrysersurennocr” p TowKa 4, B onaxoskara na AGaxanup/JIamusyaux Cariioa va cura Kkapra, Koso Hanomns Ha Bac ¥ Ha MenMMICKHTe Ata OTHOCHO CEPEXSYBCTBMTEAHOCT KEM aGakasup. Hocere Tas kapra NOCTOsHHO Beebe cH. Kaxwo coanpuca Taam aucropKa Kaxso npeucrasnasa AGakasnp/Jlamusyaunt CaHzos W 5a KaKEO ce HSnOM3Ba Kaxso TpsGea ja staete, mpesH Jia mpemere AGakannp/JTasmeyque Cax03 Kax aa npveware AGaxasmp/Tiamuayann Caxa03 Busoni wexemar peakionn Kak a cexpanapare AGaxapup/Jlamuaynnti Catit03 Comppxare Ha onaKoskara H Jomumtirenna uicbopMaLyas Seen 1. Kaxno npeyerannasa AGaxapup/JIamupyamn Canis 0 38 kaxpo ce 300138 AGaxapup/Jamupyaun Canao3 ce ustossBa 3a revenue Ha undexuus ¢ XHB (sonemum MMyHosepuqaTeH BUPYC) NPM BLSpAcTHu, 1oHOMTE H AeNA ¢ Terao Haii-ManKO 25 kg. AGaxannp/Tlawmeysu Carinos chirepica pe AkTUBHH BeUIeCTRA, KONTO Ce HBNONGBAT 38 NeeHHe Ha XMB wndexuns: aaxasup 4 namusynmy. Te ca or rpynara Wa aittHperpoBupycHHre ekapcrEa, Hapewenn iyieasudnu ananosu unxuGumopu na o6pamnama mpaxcxpunmasa (NRTD. AGaxanup/Jlamusyaun Caiii0s He Nekysa Harrenko XHB undhexunsra; MeKapcTBoTo y KORHYeCTBOTO Ha BHpYca BbB Baul OPraHHSEM H TO MOAADKA HA HHCKO HBO, ‘puto ynenuuasa 6poa ua CD4 xneriare » xppsra Bu. CD4 Krerrurre ca Bi Gel KoutTo ca BKHH Ga NoANOMaraneTO Ha oprantaMa B GopGara ¢ HHdeKuETA, ‘He acexu orrosaps Ha xosenHero © AGaxaBup/JIaMByAMH Mo esHH H CbINH Hat sexap we mpocteaana edbexTHBHOCTTA OT JIEHEHACTO.2. Kaxeo rpa6pa aa suaere, npenu a mpuemere AGaxasup/Jiamnsyann CaHnos He upuemaitre AGaxapap/JIamusyamn Canzos: ako cte aneprusmu (coperupscmeumenin) KoM aSaxapHp (HH KEM HAKOS APyTO HlexapeTso, Ckmbpacauio aGakasup (Hamp. Tpaamemp, TpHyMmex wid 3uaren), KEM aMMBYAHH WIM KM WIKOA OT OCTAHARUTe CECTABKH Hid TOBA NexapcTno (HaOpOeHH B ‘TouKa 6) Buunareso npoverere msaTa undopMauua OTHOCHO peakMHETe Ha capsxayncrearesnoct B ToaKa 4. © ako Hmaze reaxco wepnompoGuo sa6oampane ‘Yeexomere Banus jtexap, ako MHCmTe, He HAKOE OF NOCOMEHHTE NO-Tope ce OTHACE NO Bac. He npnemaitre AGaxanup/JIamuayaun Caxxo3. ‘OGupnere cneumasno BumManue opu yoorpe6ara ua AGaxasup/JIamusyaun Canzos ‘Haxou xopa, npvemauyy aSaxasup/naMusyAHH WIH pyro KOMOXHHparo severe 3a XB, amar THoBuweHt PHCK OT cepwOsHH HewenaH peakinm. TpaGBa Na NOsiaBare AOITAMEETENTETe PHCKOBH baxropu: * axo Haxora cre Hani Yepuo7apoOuo saGonapae, akmionTeno xenatit B wun C (aKo are marbexiuas ¢ xenatur B, He crupalire npHema na AGakabup/Jlamuaynun Cangoa, 6e3 aa cTe ce nockseTsann c Bala neKap, Toil keto xenaturst Bu Moxke a ce NpOaBH OTHOBO) © ako cTe Che 3HAYHTENHO HAAHOpMeHO Tero (ocoBeHO ako cre eH) © ako cre c amaGer H manomsBave HCynHH + _axo muare mpoGsaenn ¢ 6s6peunre Topopere c Bama aexap mpea a usnoassate AGaxapup/JIammnyaum Canes, aio comarare, 4e aakoe OT HocoNesmTe n0-rope TeEpaeMus ce oTitaen x0 Bac. Moxe fa € HeoBKoAHMO NPOBEAIANE Ha AOTRAKHTESHN NpernesM, RKMONITENHO HHA KPBAHTE ocaesRantix, JOKETO MpweMate nexapcrsoTo. Buaxre Towa 43a uowewe MEgopMAuNA. Peaxnuu na capnxuyncrauTeswocr kum a6aKanup Zopu naunermu, KouTo Haat HLA-B*5701 rex, Morar ace nak 1a passHsr peakuni a eopaxayncramresmocr (rexxa anepriutia peau). Tpoverere summatenuo usaara mngopMaiis oTHocHo peaxnus Ha copexsyncromrennoct p Towa 4 Ha TaGH AHCTOBKA. Puck or enpaeven yaap He moxe sa ce WsKMIONH BepOsTHOCTTa aGaKABMD Ja € CBEPIAM ¢ NOBMIeH PHCK OT CHPAENEH. aap. ‘Ynegomere Baumna siekap, axo nmare npoGneM cic ceptiero, axo MyIMirTe HH CTpasieTe oT saGonapane, KoeTO MOBHUIaBA PHCKA OT CEPNeSHO AGOATEAHC KATO BHCOKO KPEBHO wansrane wiu nuaGer. He cnupaiire npiewa Ha AGaxasup/TIamupyaun CaHin02, OcBeH KO Baunsr nexap Bu nocssetna ja ro Hanpasure. ‘Caexete 3a noseara Ha BaxHE CHMETOME ‘Haxou xopa, KowTo mpwemar nekapcrea sa XHB undexuua, pesBupar ApyrH 3a6ONABAHHA, KOHTO Morar na Gigat cepwosHy. TpaGea fa nOsHARATe BUKHHTe NPHSHAU H CHMITTOMM, 38 78 CHIEAHTE ‘uuwaTenvo 3a noxeaTa va, ZOKaTO TpHenare AGaxaaup/JTamueyann CaHa02. Tipoverere unopManusra JIpyri BLIMOXHH HEKeIANH PeaKNUN HA KOMORHNpANATa ‘Tepanna na XHB" » rouka 4 or wacrommara 2ucrosKa. Tlasere apyrure xopa XHB wndexijorra ce mpenasa pes cexcyaneH KONTAKT © HOREK, KOHITO € HI ‘3apaseHa KpBB (HANPHMep Ypes HINOTIRAHE Ha EHH H CBU HIM 3a HEAKEKUMH). ‘Toba sleKapeso, Bue ace owe Moxe na mpeaaiere XB, menpexn ve Prcxot ‘edextusna anTuperposupycia Tepamus. O6cenere ¢ Baus sexap Mepka, 3a na waGerneTe HAGbeKTHpaHe Ha pyr Xopa. 3Apyra xexaperea w AGaxapup/lammsyaun Canxos Muopmupaiire Bamus rexap wm apmauest, ako npueMare HH HACKOpO cTe UpHeManE ApYFHt eKapersa, BicOWITeTHO GHNKOBH NeKApCTBA HI APYTH JeKAPCTBA, KONTO CTE CH KYTIL 6es peuerra. He sa6panaiize aa yeenomure Bauras nexap iit Gapwauiesr, ako aariownieTe fia npHeMaTe HOBO slekapeTeo, noxaTo cre Ha weveHHe ¢ AGaxapup/lannayan CaHn03. (Caeauure nexapersa ne Tpx6pa ua ce npuemat eqnospemenno ¢ ASaxanmp/JIaMaByAmH Cauges: ‘+ ExrpanrraGint 3a neverne Ha XHB mgexuna ‘*_apyri nexaporeenH MpoxyKTH, CoBPKALIK sIAMKBY/AMH, KONTO ce HsnoNsBaT 3a nesenne Ha XHB undexnua 1H uadexqea ¢ BEpyea Ha xenaTaT B ‘+ BUCoKH 03H TpHMeTOUpRM/cy.pameToKeAsoNL, AHTHOHOTHK * anpuOwn, uanon3eaH 3a neveHMe Ha KOCMATOKETEYHA NeBKEMEA Kaxere ua Bamus xeKap, ako ce slekyBare ¢ HaKoe OT NOCOMeHHTe TO-Tope NeKapcTss. Haxou nexapera ssaumonelictsar ¢ AGaxasup/JIammeyanu Cannes Tosa sxmoupa: + Gemmroms, xoliro ce usttonsea sa newenHe Ha eNmAencHs. ‘Kamete wa Bauins siexap, ako mpnemare dbenxtown. More aa ce wanoxn Baunorr neKap na BH npocnenssa, 1okaro npuemare AGaxasup/lammaysia Canines. + merazou, xofiro ce wsnosssa KaTo saMecTaTen Wa xepoutia. AGaKaBHp NOBMINABS ‘ckopoctra, ¢ KoxTO MeTasoHA ce OTNeNS OT opranticaMa. AKO MpHeMaTe METAAOH, We SaneTe npocneammann 3a nlogpa Ha cHmTOMH Ha OTHeMaHe. Moxke Ja ce HANION NpOMAHA aa ZosATa METaZIOH, KOTO NpHeMaTe. Kaoxere na Bammus siexap, ako npyemare meraion. + puGapupmn, wotiro ce wsnonsea 3a nevexue a xenarur C. AGaxasup Moxe a HAMANH eauacuocrra wa KoMOHHalnUrTa pHSaRHpHH Hi KerHTKpaH HEITepspepOH MPH PeAYUMPAHE HA ‘HMBaT Ha BApyca Ha XerlatuT CB OpraHHsMa. Kawere ua Baurua xexap, ako npuemare pxGasypiu, Bpemennocr AGaxanup/Jlamunyaun Canyos we ce upenopsysa sa upusoxenne no Bpeme ua Gpemeanoct. A€axanup/namusyamn noxO6HH NexapcTBa MOTaT @ NPHYHKAT HeAkeNAHH PeaKIGAH pH HepOmeHATE GeGera. Axo sa6pemeneere, xoKarTo npHemate AGaKaup/Jlamusynnn Canmo3, BamteTo GeGe mome st Gene nomnoxeHo Ha ROMEAHATEUEH HCTEABAHMK H Mpere”H (BKIIONATENHO KPKBKM HICHIENBAKMS), 3a € cHTypHio, He ce pasnma HOpMamHo. Axo cre Gpemennia, sa6pemeneere nix miaupare 1a sa6pementeere: ‘OGcenere neamara c Banus stexap pickosere m nosauTe oF npHema Ha AGaxanup/Jlanursy ae Canqos an npyra seKapcTea 2a nevenne Ha XHB wvidpexigns no speme na Bamara GpemeHHocrt. Kepmene Ken, kouro ca XMB-noswrunun, we TpaGea 1a kwpmstr, Toil Karo XB wnexu ce mpenane ua 6eGeTo pes xepmura, Manko KonMMecTao or cucTanKiTe Ha AGaKaBuip/ Canaos woxe cbillo Aa npeMute B KEpMaTa. Axo KUpMHTe 11H cMaTaTE Jia KBpMuNTe? Hesa6anno ce koucysrrupaire c Bama xexap. pr Tlopmpane u paGora ¢ mannanAGaxasnp/Jlammsyann Cantos Moxe 1a MpHUMHK HEMEARH PeaKUHM, KOHTO Aa sacersar BauiaTa choco6Hocr sa moimpane win paGora c ManrH. ‘O6ceaere ¢ Bama zexap cnoco$noctra Bu 3a wodpapare wiH paGota c MaLIMHM, AoxaTo npwemate AGaxasxp/Jlamoynim Casino. Baxua ungopmanus oTuocao maxox or cocTankure ua AGaxapup/Jamusynma Cangoa AGaxasyplTawnayann Canos cumepxa ouperuren, wapeven cbticeT 2xbTO (E110), xodiTo MoM a [pwn aneprusen PeaxayAn NpH HAKOH Xopa, 3. Kax na upuemare AGaxannp/amunynun Cauca Bunarw npaemaiire Tosa aekapetso Toao kaxro Bu ¢ xasan Bamuat sexap. Axo we cre ‘curypim B Heuto, nonTalire Bama 2exap naw cpapwauesr. Tipenopanrenusta xosa AGaxapap/JTasupyaun Cargo 3a BESpAcTHE, fOHOMIH H AEMR ¢ Terao 25 kg uu nopeve e enua TaGneTKa BeAWEK AMeBNO. Tlormsmaitre taGneviarre yen, © ManKo Bona, AGaxanup/Jlamuyan CaH0s Mowe a ce mMpHeMa cK ‘nm 6e3 xpania, ‘Tloamspaaiire nocrosna apsaxa c Banna zexap ‘AGaxanup/Jlancusyane Canes nowara 3a xotrpommpanie Ha Bauiero se6onsnane. Tpx6na na TPOMbIDKHTE 1a NPHEMATE /eKAPCTBOTO BCEKH eH, 3a 1a HE NOSBOMIHTe Ha SaGonsBaHeTo Bu na ce Roun. Bes ome Moxe fia pasbHeTe MpyrH HEgeKIHH KIM saGonsBAHHs, cBbpoan ¢XHB unexunara, Togxspxaiire xonaxr ¢ Bamina aekap we caupalite mpnema ua AGaxapup/Jiamunyaua Camgos Ges KoHcyaTauta c neKapa. Ano cre mpueu noseve or neoGxommmara nosa AGakapup/Jamanyans Cannes Ako Tio eayualinoct ote mpnemH Noseve oT neoSKomMMaATa nO3a ASaxasHp/Jlamunyame CaHn03, ‘Yeenomete Bawns stexap, bapmanest Ww ce oGagere Ha Bepsa NoMOML 3a OMBIKUTENCH CBBET, Axo cre uponycuaau Aa npuemere AGakanup/JIamunyaua Cangos Ako mponycxere 2a npHemete 203a OT NekapeTBOTO, NpHeMeTe A BEHAra CieN KATO CH COMHHTE. neq Tosa npoasmnxete BauteTo nevexte xakTo pens. He poewalfre ofitia 10%, 20 8 xonmewcupare mponyciarara 2038. Baoxxo e a mpeware AGaxasnp/JTaunaynut Cantos penoano, Toit KATO HepenOBHHAT mpHeM Ha “HeKapcTaOTO NOBHABA BepORTHOCTTA 38 PAIBHTHE HA PeAKUNX Ha CBPBXYYBOTBHTEAHOCT. Axo cre empeau mpuema ua AGakasup/Jamunyaua Canyos ‘Axo cre crpemm mpvema na AGaxapup/Jlammsyzun Caos nopanm HakaKea npHausia — ‘ocoSeHo axo MHCITTe, Ye UMaTe HEAeNAHK peaxuMM HIM NopagM pyro sa6onaBaHe: Tosopere c Baman sekap npeau 1a saowHeTe 2a NpKEMATe JeKAPCTBOTO OTHOBO. ‘Bawa aekap we nposepu anu cinarrromure BH ca cava ¢ peaxiyis Ha ‘eapxyyBcTBieTenHOcT. AKO sIeKaPAT pel, Ye CHMMTOMHTe MOXE Ja CA CEUPAH ¢ PeaKIBIE ia capexuysorsiremniocT, me Bu Kaxe HHKOTa NoBewe Aa ne NpHeMATe A6axasup/Jlamnpyanu Caiios mam koeTo H a € pyro sleKapCTBO, chit paca adaxapup (sanp. Tpusmpap a8 3uaren). Baxno ¢ na cnemaate TOs cBBeT. Axo Bauust nexap Bu noctsersa aa sanowneTe oTHoB0 fa npuemare AGaxaBstp/ Cannos, moxe 1a GbneTe NOMONEHH Ja TPMeMeTe MEPBHTe 03H HA MACTO, KENETO 1 onystTe HesaGanta MEsIMUHCKA NOMOUL, AKO HMATE HYAa OT TAKABA. 4, Besmoxma nexenany peaxmunKaxto scwsxi aekapeTsa, TOBA slekapcTBO NOKE JA MIpeAMIBHKA HEENAHK PERKIN, REMPEKH We HE cekit rH nomysana. Koraro ce aexysate ot XMB widexuns, He BHHArH MoxKe 2a Ce OMpenenH AANH ONpeneIeH CHMNTOM & exenaya peaxus, cBypsaHa ¢ ynorpeGaTa na AGaxannp/JlanByan Calil0s WM NPyrH sleKapeTss, ONTO mpueare no CémlOTO Bpeme, Hi e NposBa Ha XHB Gonecrva. arona € MHOTO BRAHO 18 yeeuomanare Baiius slekap 38 BeHKH POMEHH B IApaBoCHOBuOTo cu CLeTOmHNe, Tope naxwewra, Konto tamer ren HLA-B*5701, Morar na pasbust peakiHa wa ‘CBpbxUyBeTBTERMOCT (TeaxKa aNeprHutia PeAKil), KORTO € OUMCAHA B TA3H AMCTOBKA B ‘TouKA ,,PeakUHH Ha CBPBXYYBCTBHTEHOCT”. ‘Muoro e panaro aa mpoverere wa pasGepere undpopmanunta sa Ta2H cepuoas peaknss. Ocnen nememanure peaxnun, n26poenH 10-Aony, KONTO ca CBLP3AHH Cc MpHeMa Ha AGaxasup/Jlamnsyaun Cantos, no speme He xouGupaHo nevesme Ha XUB, Morar fa ce asoueT H pyrH CRCTORHUS. Baxaio e 2a mpowerere mupopmansurra 8 Towa ,JIpyru wesMOxH HEAETAHH peaKaH Ha xonGrampaniata Tepamus na XHB” a raau mcroeka. ‘Peaxnum wa eapexyycreuTeauocr Abaxapup/Jamubyaun Cangos cirspxka abaxanup (KOCTO € aKTHBHOTO BEIIECTBO H B ‘exapotaata Tpusuaup, Tpuymex u 3marem). AGaxKasHp MOXe Jia MpHMHEH TexkKa alepryscaa PeaKup, MBBECTHA KATO PeakUia Ha CBPLXYYBCTBHTENHOCT, TEM PeAKITH HA CEPEXYYBCTBHTENHOCT ‘ca HaGmonaBaH NO-YeCTO MPH Xopa, NIPHEMAILIH NEKSPCTBA, KOMTO CEALpIKAT aGaKADHp, Kot nonysasa resm peaxnuu? Beexs, xoliro npewa AGaxanup/Jlamusyannt Cantos, Moke 7a pasniie peakuns Ha ‘copHxSyBCTAHTTENHOCT KEM abakaBKp, KONTO MOE A € AHEOTOGACTPAUIABALIA, AKO NPORWOKH npvewer na AGakapup/Jlamupyaun Caos. Beposruoctra na passueTe Tasu peakuMs € no-ronaMa, ako Mare rex, napeven HLA-B*S701 (Ho Moxe aa passueTe peaxuus u Ges aa mMare TosH Tex), IIpenH 4a sanowueTe na mpHeMaTe Abaxasup/Tiaauayzuun Cantos, TpaGsa 2a Bu 65,Je Hanpavetio HocreBaHe 38 TO3H rel. ARO aniaere, Ye uMare TOsH Fell, YRenOMeTe BAMING JexAp, NpeaH Aa 1anoquere pHeMa HA ‘AGaxasup/Jlamnsyann Camos. B roamruo npoyssarie oxoro 3 10 4 wa scexn 100 maura, nexynann © aGaKaBip, KOHTO He ct nani red HLA-B*5701, ca pasbiiau peaxinix Ha cEpDxsyecrexrestHocT. Kaxeu ca camnromuTe? Haii-wecrure canarron ca: © rpecka (evcoka Temnepatypa) H Konteu O6pxB, Apyru vectu cummromu ca: © anew, nospemave, anapiis, kopentia (croMaula) Gonka, cHIHa yuopa. Apyru cauntom skmosnar: Boakn 8 crapure WH MYCKyaIHTe, NORyBaHe Ha IuHATa, SaZYX, BaMAeHO TEpAO, MpHcTen Ha rnao6omne, BBsnaNeHHE Ha OKOTO (KoMONKMUEWI), 3B B YoTa XPBBHO HankraHe, HSTpEIIEAHe WI MpAByaKaHe Ha PBUETe HIM Kpakara. Axo npomairaarre a mpuemare AGaxanup/Jlamupygun Caujos, cumnromure S ce paoMar u Morar ja cTanaT xuBoTosAcrpaMaBaLiu. Kora ce pasauear resn peaxuPeaxunurre wa capBxyyscrsiresHocr Morar ja Ce NOABST 110 BCSKO BPEMe, NOKATO MpHeMaTe AGaxapup/JlamusynHn CaHi03, HO Hall-HecTO Ce NlOxBABAT Nipes MepsinTe 6 cemMMUK OT aeveHmero. ‘HesaGasuo ce eoupmere c Baumn wexap: 1 aKomoxyanre Spas HI 2° ako noayauTe cummToMH OF Haii-mamko 2 or eequmTe rpym ~ nosuwieHa Texmeparypa + 3aMyx, BESTANEHO repo HAM KANLTHNA ~ razeHe WIM nospBtaHe, Mapua Hun KopeMHa Goska ~ Texcxa yMopa Hn Gomki, Wik OOuIO HepasnonoxkeHHe, Bauusr nexap moxe aa Bu npenopeua za cupere upwema ua AGaxapup/JIamneyaun Canzo3. Axo cre cupea npuena na ASaxanup/Janusyamn Cannes, Axo cre cnpens mpwena wa AGaxasup/Jlausyayie Cax03 nope peaxuia Ha cupexsysctanrentoct, HHKOTA OTHOBO ne tpa6sa aa upuemare AGaxapup/JIamapyamn (Canqo3 wun apyro sekaperso, koero ckaepas aGaxanup (Hamp. Tpazmpup, TpHyMeK WH Suaren), Axo To Hanpasitre, B panuirre Ha 4acoBe MO:KE 2a HACTSIIM ONACHO CHRNAHE HA KPEEHOTO Bu ansrane, Koeto Ja aowene 10 cmepr. ‘Axo ote enpesu npwesa Ha AGaxasyp/Janmmyaum Caxio3 nopadit HAKaKsa punta - oco6eH0 AKO MucaITe, 4e pasBHBaTe HeAKeTOHH peakin WH Apyro 3a6onaBAHe: Koucymrupaiire ce ¢ Baumus siekap, npeau a sanownere an mpemate nexapetBoro oruovo. Bauiusr nekap mle MpeteHH JAH CHMITTOMHTE Ce KAT HA PeaKIVIA Ha capaxuyscrsHTemHOcr. Ako NekapsT MUCTH, “e Te Moxe Ja ca ceBpaaHH, me Bu kawe BuKOrA noseve Ja ue upuemare AGaxasup/Jlamasyaum Cano Ham pyro eKapero, chawpaamo aGaxasup (namp. Tpususup, Tpuymex wan Suarew), Boxio ¢ 7a cneaRaTe TOs cuper. 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Peak nexenann peaxumn Te morar na sacersar go 1 wa 1.000 nyu: ‘*-4epHonpoSun yepeacnarns KATO aRTTeHHHA, yBEsHNeH SepeH APOO, YBCNHUARAHE Ha MasHAHtTe 8 YepHNA sIpO6, BESMATeHME (cendmum) *aaxratia auniaosa (6uxcme cnedeaiyama mouxa ,.{pyeu seamonciu neswcenanu Peay Na onGureupanama mepanus na XHB”) ‘© ppsnanenme wa nasxpeaca (namxpeamuon) © paaxeesaie Ha MycKymna ToKaH, Peakn vexenatm peaxuv, KOWTO Morar fla Ce MPORBAT MpH HICENBAHHA HA KPBETA ca: © Mosiumasane na rnmoTO Ha cHBHM, HapeseH axunaza. ‘Muoro peaku nexenann peaxaia Te moran na sacernar ao 1 wa 10 000 ayumi: © wotpsimane, yeemane 3a USTpEuBaNe Ha KOKaTa (uTmCUKH H MpaBysKaHe) © -ayscrpo na cna6ocr B kpaMHuTe . ‘KOMEH O6PHB, KOHTO MOIe Aa € ¢ MEXYPH H 2a YSMNOKIA KATO MILIKH MHLICHH (TBMHO NETHO B LIeHTSpa, sa0GHKOReHO OT Nlo-cBeTIIA OONACT ¢ TEMeH NipEcTeH OKONO Hes) (erythema multiforme) © uupokopasnpocrpavex OGpus c Mexypit H Geslene 1a KO:xaTA, OCOBeHO OKONO Yerara, HOCa, ‘O4nTe H NONOBHTe opranH (cundpom na Cmuswuc-JocouceH), KAKTO H TIO-Texka GopMa Ha ‘Tost OGpuB, NH KoxTO Ma Genene Ha noBeHe oT 30% OT KoXETA HA TLIOTO (moKcuena enudepmanna nexponusa). HesaGanno ce caspaere c exaps, axo saGenexuTe HaKoli OT Te3H CHMITOM! Muoro peaku HexenaHH peakuHH, KOTO MoraT na ce HAGmIOMABAT B KPBBHE TeCTOBC, ‘* HECHOCOGHOCT Ha KOCTHHA MOSbK 1a NPOHSBE@KA HOBH YepseHt KPLBHK KCTKH anaast na vepeenume Kpoaru KnerKu), Axo noayunre weaenanu peanmnKamere wa Banus exap nam gapmanent, ako HiKOs OT HEeMAHNTE ekapCTRCHH peaKin crane cepHosna wii oBeanloxouTesmia, HIM se6enexCITe DPYTH, HEOMICAHH B TASH AHCTOBKA ‘ewenauH peaxu Apyra ovsmoxuu nexenann peakuan ua komOmEupanara Tepanus ua XHB KonGusupana tepanus, KATO Ta3u ¢ a6akaBup/naMMByANH, MORE 11a ROBE 2O PASBHTHETO Ha pyra saGonssaHs no BpeMe Ha NevesHeTo Ka XHB. ‘Cuncrowm ua nnpexnus u Biananenme ‘Crapu unexumm, xonTo Morat 7a ce nosBaT oTHOBO Xopara c Hanpentiara XHB axcbexums (CTIHH) wer orcnaGena mmynna cucTeMa Hpi THX. BeposTHOCTra 9a pasBHITHe Ha cepHosH HHepeKLUAM (onopmonucmuesnu uncbexyueu) € TO-TOnaMa. Team ungexuor moxe na Geaat ,THXH” H a He ce OTKpHBAT OT cnaGaTa MMyHHa CHCTENA MpeNH ‘sanouane wa neuenne. Cea sanowBave Ha neYeHle, HMyHHATa CHCTeMA Ce SACHLTEA H MOE 18 aTaxysa MaKpeKuMiTe, KOETO Mo%Ke AA NPHMIMEH CHMIFTOMM Ha HEIDEKUAS HH BESTIAMCHT, (Cwnitrromure O6uKHOBeHO BKIMO'NBAT TPeCkA HHAKO OT Cre AHITTE CHMIFTOME: © masoGonie © Gomea » cromaxa © sampyzneno qumane B penxu cnyyan, Teil kaTo UMytHaTa cHcTeMa ce SACHIBa, TA MODE JA @TAKYBA 3UpABa TEKAH B ‘opraniasa (aemounynnu napyuentet). CHMMTOMHTE HA ABTOHMYHHHTe HapyUICHHA MOTaT Aa ce ASBUAT MHOTO MeceLIM CHER 3aTlOBAHE Ha MIpHeMa Ha NeKapcTBO 3a NeveHMe Ha XHB wudexyes. ‘Cuuurrrommre Morar fa BxOuBAT: © nannurramma (yexopex uM HepaBHoMepett Tite) HH TpenepeHe ‘* cepexaxrusnocr (npexomepHo GestioxolicTso abicxeHHe) ‘© cma6ocr, sanowpauia » puuere u KpaKaTa H pasnpocrpaHsBaUla Ce NO UANOTO TANI. AKO TORYaUTe CHMNTOMH Ha HHMEKMRS H BEIMANCHHe HTH ako SaBeeKHTe HAKOH OT ‘cuwatTomitre, 6poeun no-rope: HeaaGasuo xaxere wa Bausus -texap. He npuenalire apyru sexapcrsa sa uacbexunuera, Gea Batnsr aexap a Bu e nocesersan 3a Tosa. ®opuar ia Bamteto Taso Mowe ja ce mpoMel Xopara, xouTo npxemar KomGuspana Tepamit sa XB, Moxe na saGenexkar NpoMeHH BE opmara na TaIOTO NopaaH MpOMsHA B paanpeneneHHeTO Ha MACTHA THKAH: ‘+ Sary6a na MacTHa TexaH OT KpaKaTa, PbUCTE WIK MHUETO. * Jlomsnnmrento Harpynpavie Ha MACTHA TEKAH B OGnaCTTa Ha KOpeMa, rEpaHTe WAH DSTpeUMATe oprah. + Ha sanwara wacr na ppava Morar ja ce nosist wacrin 6yskx (nlosKora HapHuaHiK “Gasoucka rsp6nue”). Bee oie He ca HSBECTHH MpHHHHTE 3a TesH NPOMEHH, KAKTO H ANIM Te MMT ABATOCPONHH ebeKTH supxy Bawero anpane. Axo sabenoxuTe mpomes mes opwara Ha Bauieto TaN0: ‘Yuenomere Baumns aexap. Taxraruara anuqosa e paaka, wo cepuosua Hexenana peakives pa axon naurerna, xowro npwemar aGaKaBup/namusyann IH spyrH NonOGHH (ayxneosMMHH aHai03H HEXKGHTOpH Ha O6paTHata TpaHcKpunrasa (NRTI)), ce CHCTOMHMe, HapeeHo NAKTATHA ALTAO3a, 9AeN1HO C YeenMMaBAHe Ha YepHHN BpO6. Tlaxraritara aunaosa ce npHHtinea of Harpynsaxe Ha MuIeuHa KHCeAMHA B TAIOTO. CucrosrHeNs tani aGmonana panko H MOme Zia Ce panBHe OGHKHOBEHO HAKONKO MECeUA GEN HaMAnOTO Ha NeeHHMeTS. Jlaxraruara aujosa Mowe fa € KHBOTOSACTpAlABaua, IpHYHHABAKH HeNOCTATB4HOCT Ha‘BBTpeMTe OpraHH. Tlo-ronawara seposTHocr 3a BBSHHKBaHe Ha nakramHa auiIO.a HMA MPH xopa c NepronpOSHO saGonaBane WI SaTmcTaBane (3HaHTEIHO HaHOpMEHO Tero), ocoGeHo Np 2KeHH. ‘Upasuamare aa nascrarma anujosa piemoanar: TajleHe, NOBPLUIaHe Goma 8 cromaxa 60 nepastionomennte sary6a wa anti, sary6a na Tero BAGOKO, yaecTeHo, sarpyanieHo myWAHe ckoRaHocT wiv cnaGoct Ha kpaliucuure Tlo speme Ha nevennero Bamusr nexap me Bu naSmmosasa 3a npHaHaNM Ma TaKTaTHa aupanons. AKO Tony'ite HAKOI oT HI6pOeHHTe 110-TOpe CHMITOME, HTH KABUTO H ja GHNO APYTH CUMITOMH, KOMTO Bu npirecuasar: Busmoauo mail-Gxpso ce koueysrapaiire c Bauus nexap. ‘Mone 2a umare npo6iewn ¢ KocTaTe Ip uaxou xopa, npwewaun komOuruepana tepanmx 3a XHB ce paseisa cECTOsHMe, HapeHeHo ‘ocmeonexposa. Tipit Tova CKCTOMHME ACT OT KOCTHATA TBKAM YMMpa TOopai HAMANZBAH HA xpbsocuaGaawariero Ha KocrTa. BepoxTHOCTTa ALMeHTHTe a pasBHAT TOBA CECTORUe € NO-TONIMA: ‘ako ca GHi1H Ha KOMOMHHpaHA TepanHa 3a MPOAWDKHTeNeH NepHOA OT BpeMe AKO MpHeMaT cpio MPOTHBOBESTIAANTENHH NeKAPCTHS, HapeHeHH KOPTHKOCTEPOHAH ‘AKO KONcyMpAT ANKOXON aKo HMYHHaTa HM CHCTEMA € MHOrO cxa6a aKO ca ¢ HanlHOpMexo Terno. TIpasuaqure ua oereoriexposa skx10unaT: ¢ cxosanoct 1a crasite © Gonka (ocoBexo » rasoSenpeHaTa capa, KONAHOTO HIM paworo) © TpyaHocr 8 aBwKeHsra. Axo saGeneaxiTe Tlompata Ha HAKOH OT Te3H CHMITOMH: Kaxere na Bautaa xexap. Apyra peaxnua morar ja ce poss » xpupunTe woeaeqnaHEa KonGusupanara tepanux ua XHB mone 1a 1obene ole 10: + TOBHIIEHH Husa Ha MTeNHaTA KHCEMHHA B KPLETA, KOETO B peAKH OHYYAM MOK a ‘RoseNe 20 panpuTHe Ha NAKTaTHA AUHROSA TOBMUIeHH Husa Ha 3aXap H MaSHin (mpuenuyepudu H Xonecmepon) B KpLBTA eBHCTENTHOCT KEM HHCYAHH (TAKA Ne, AKO CTE AMAGETIK, MoHKe A C€ HALO MpOMAHA Ha ‘Rooara Ha UHeyavHa, HeOGKORHNA 3a KOHTpompane a kpuEHaTa BH saxap). CroSuazane Ha nexenamu peaxm ‘Ako niomyanre HEKaKBH HeXxwimmpan TaGneTKH B GyTHAKH, ChmSpAKAINM Calne ¢ AKTHBUPAH BBTCH WH Cale C AKTHENpAL Borex» a6copOaTop Ha KHesIOpoA, 3a Jia Ce KOMTpONHpa arava B GyrHmKaTa, He acuexn siinose onaxoskn Morar sa Geyer nycHara 8 npoax6a. Lputexaten a paspeuieunero 3a ynorpe6a Sandoz d.d. 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