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Datasheet of cGAMP(Cyclic GMP-AMP)

Description:
cGAMP(Cyclic GMP-AMP) is an endogenous second messenger in metazoans

and triggers interferon production in response to cytosolic DNA; STING ligand. Target: in vitro: cGAMP induced IFN RNA

robustly even at concentrations as low as 10 nM. cGAMP was much more potent than c-di-GMP in inducing IFN based on

ELISA assays. cGAMP was also more potent than c-di-GMP and c-di-AMP in activating IRF3. cGAMP binds to and activates

STING to trigger the downstream signaling cascades. On stimulation with cGAMP, fibroblasts from the patients showed

increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor

(TNF). cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the

secretion of type I IFNs. in vivo: cGAMP can enhance the adaptive immune response to the model antigen ovalbumin in mice.
cGAMP promotes antigen specific IgG and a balanced Th1/Th2 lymphocyte response in immunized mice.

Chemical Information
Catalog DC10482

Purity of current batch: >98%

Molecular Weight (MW) 674.41

Molecular Formula C20H24N10O13P2

CAS No. 849214-04-6

Solubility (25C) DMSO

Storage Store at -20C (desiccating conditions).

Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room
temperature for at least 1 hour.