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Research Impediments

The document summarizes research being conducted to develop an oral tablet dosage form containing the pigment nasunin extracted from eggplant peels. The researchers extracted nasunin using methanol and water filtration and tested the extract using HPLC. They also conducted studies on the preformulation of nasunin tablets and potential interactions with excipients, as well as toxicity studies using an unspecified animal species to identify any toxic effects of the drug product. The research is being performed at the University of Santo Tomas in Manila from 2016-2018.

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Don Nestor Razon Jr.
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1K views1 page

Research Impediments

The document summarizes research being conducted to develop an oral tablet dosage form containing the pigment nasunin extracted from eggplant peels. The researchers extracted nasunin using methanol and water filtration and tested the extract using HPLC. They also conducted studies on the preformulation of nasunin tablets and potential interactions with excipients, as well as toxicity studies using an unspecified animal species to identify any toxic effects of the drug product. The research is being performed at the University of Santo Tomas in Manila from 2016-2018.

Uploaded by

Don Nestor Razon Jr.
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
  • Research impediments

Research impediments

The nasunin pigment was extracted from the exocarp by maceration and filtration,

dried, treated with methanol and distilled water, distilled again by using Sep-Pak C18 that

is activated with methanol and distilled water and resuspended in a solution of

trifluoracetic acid (TFA). The outcome of the extraction was tested using High

performance liquid chromatography (HPLC). The extract of Solanum melongena L. peels

was filtered by using a Sep-Pak C18 cartridge, obtaining a first elution in methanol

(Solution B colored in brown) and a second in distilled water (Solution A colored in

purple). Both eluates were dried and weighed. Were obtained, respectively, 0.6523 grams

for the dry residue A and 0.2110 grams for the dry residue B. The two samples were

resuspended and analyzed by HPLC (Zhang et al., 2004; Sadilova et al., 2006, as cited in

Gallo et al., 2014).

The study is conducted at the University of Santo Tomas at Espana Blvd, Sampaloc,

Manila, Metro Manila during the 2nd semester of School year 2016-2017 up to the 1st

semester of school year 2017-2018.

The research is focused on the preformulation of Nasunin into an oral dosage form,

tablet, and to determine the possible reactions of Nasunin with the excipients that are

used to develop the dosage form. Toxicity studies are also included in the research to

recognize any toxic effects produced by the drug product. The drug product was tested

on ___(animal species to be used I not yet known)___ from ___(place where to buy

animal not yet known)____.

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