MANISIT DAS

Mobile: +1-919-537-5503 E - mail: manisit@email.unc.edu https://www.linkedin.com/in/manisitdas/

Home Address: 2701 Homestead Rd, Apt 809, Chapel Hill, NC 27516
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Research Interests

Cancer Immunotherapy, Drug Delivery, Nanomedicine, Non-viral Gene therapy

Education

Degree Year Board/University % Marks/GPA

Doctor of Philosophy (PhD) Anticipated University of North Carolina at

Pharmaceutical Sciences May 2019 Chapel Hill, US

Integrated Master of Science July 2015 Indian Institute of Technology 8.82/10

(B.Sc., M.Sc.) Chemistry (IIT), Kharagpur, India (Departmental Rank 1)

Publications

Published:
Transient and Local Expression of Chemokine and Immune Checkpoint Traps to Treat Pancreatic Cancer Miao L; Li, J; Liu, Q;
Feng, R; Das, M; Lin, C.; Goodwin, T; Dorosheva, O ; Liu, R; Huang, L., ACS Nano, 2017, DOI: 10.1021/acsnano.7b01786
pi-Stacking assisted redox active peptide-gallol conjugate: synthesis of a new generation of low-toxicity antimicrobial silver
nanoparticles Das M. et al., RSC Advances, 6 (2016) 85254-85260
High Performance Lateral-Flow Immunochromatographic Assay Combined with Surface Enhanced Raman Spectroscopy
Cho I.-H., Das M., Bhandari P., Irudayaraj J., Sensors and Actuators B: Chemical, 2015, 213, 209214
Chitosan Derivatives Cross-linked with Iodinated 2,5-Dimethoxy2,5-dihydrofuran for Non-Invasive Imaging Ghosh P., Das
M., Rameshbabu A.P., Das D., Dutta S., Pal S., Panda A.B., Dhara S., ACS Appl. Mater. Interfaces, 2014, 6 (20), 1792617936
Under review:
Targeted Drug Delivery to Melanoma Liu Q, Das M., Liu Y, Huang L
Patents:
Chitosan based biodegradable materials for biomedical applications Ghosh P, Das M, Dhara S., Indian Patent Application -
566/KOL/2013, Publication date 21.11.2014

Scientific Presentations

Nanoparticle loaded RIG-I agonist enables effective and safe adjuvant therapy in cancer Das, M., Shen L., Goodwin T.J.,
Huang L., Poster at American Association of Pharmaceutical Sciences (AAPS) 2017 Annual Meeting in San Diego, CA
(Accepted)
Nanoparticle loaded RIG-I agonist enables effective local adjuvant therapy in pancreatic cancer Das, M., Shen L., Goodwin
T.J., Huang L., Poster at National Cancer Institute Site visit to Carolina Centre of Cancer Nanotechnology Excellence (CCNE)
2017

Research Experience

Local and transient immunomodulation in pancreatic cancer (March, 2016 ongoing, PhD thesis research), Mentor: Dr. Leaf
Huang, Pharmacoengineering & Molecular Pharmaceutics, UNC Chapel Hill, US
Remote actuation of Magnetic Nanoparticles for Cancer cell disruption (Nov, 2015 Feb, 2016) , Mentor: Dr. Alexander
Kabanov, Pharmacoengineering & Molecular Pharmaceutics, UNC Chapel Hill, US
Co-delivery of Cisplatin and Paclitaxel with nanoformulations (Aug-Nov, 2015), Mentor: Dr. Andrew Wang, Radiation
Oncology, UNC Chapel Hill, US
 Redox active peptide-gallol conjugate: Synthesis and application in generation of antimicrobial silver nanoparticles (July,
2014 - May,2015, M.Sc. thesis research), Mentor: Dr. Amit Basak, Department of Chemistry, IIT Kharagpur, India
Design of a high performance Surface enhanced Raman Spectroscopy integrated lateral flow immunoassay for
biomolecular detection (June-July, 2014), Mentor: Dr. Joseph Irudayaraj, Agriculture and Biological Engineering, Purdue
University, US
Computer simulation studies of the binding mechanism of N-succinyldiaminopimelic acid with dapE-encoded Nsuccinyl-
L,L-diaminopimelic acid desuccinylase (December, 2013), Mentor: Dr. Sabyasachi Mishra, Department of Chemistry, IIT
Kharagpur, India
Design of a Macrophage Based Superparamagnetic Iron Oxide Nanoparticle Platform for Theranostic Application (May-
July, 2013), Mentor: Dr. Yun Min Wang, College of Biological Science and Technology, National Chiao Tung University, Taiwan
Synthesis and Characterization of Chitosan based Radio Opaque Biopolymer for Biomedical Applications (May-July, 2012),
Mentor: Dr. Santanu Dhara, School of Medical Science and Technology, IIT Kharagpur, India
Technical skills

Physicochemical Characterization: UV-Vis, DLS, NMR, FTIR, TEM, Raman spectrometry

Bioanalytical techniques: Flow cytometry, Immunohistochemistry, Immunofluorescence, RT-PCR, Western Blot
Cell culture: In vitro 2D & 3D spheroid culture, Subculture of Adherent and Suspension cells
Animal models: Subcutaneous and intravenous administration of therapeutics, Orthotopic cancer model development
Formulation: Gold, Silver, Iron Oxide, Polymeric, Liposomal and Solid lipid nanoparticle formulation development

Honors & Awards

2017: AAPS Travelship to attend and present poster at the AAPS Annual Meeting in San Diego, CA, November, 2017
2015: Fellowship to University of North Carolina at Chapel Hills Biological and Biomedical Sciences Program (BBSP) &
Purdue Universitys Interdisciplinary Life Science Graduate Program (PULSe)
2014: S.N. Bose Scholars Program fellowship by University of Wisconsin- Madison & Indo-U.S. Science and Technology
Forum (IUSSTF) for pursuing summer research in Department of Agricultural and Biological Engineering, Purdue
University, US
2014: MITACS Globalink Research Internship fellowship 2014 for pursuing summer research in Department of Chemistry
at University of British Columbia, Vancouver, Canada
2013: NCTU Taiwan Elite Internship Program fellowship at Department of Biological Science and Technology, National
Chiao Tung University, Taiwan
2013: Indian Academy of Science Summer Research Fellowship at Indian Institute of Science (IISc.) Bangalore
2012: Indian Institute of Scientific Education and Research (IISER) Mohalis Summer Research Fellowship
2010: Inspire SHE scholarship from Department of Science and Technology, Govt. of India for being in top 1% in 10th
and 12th grade board exams among 700,000+ and 400,000+ examinees

Scientific Outreach

Scientific Writing & Communication Club (SWAC, UNC) Writer and editor in Pipettepen, UNC SWACs graduate student blog
(http://www.thepipettepen.com/author/manisit-das/) since July, 2016
Volunteered for Scientific Outreach night at Mary Scroggs Elementary School in Chapel Hill in April, 2017
Volunteered for HoStErs, a program for Homeschool Student Experimenters around middle school education level in Chapel
Hill to exercise their scientific and creative minds by performing science experiments, in Sep, 2016

Teaching/Mentoring

Mentored students under North Carolina School Of Science And Mathematics Summer Research Internship Program in 2017

Leadership Experience

Led a Cross-Cultural Leadership Development workshop, for incoming Biological and Biomedical Science Ph.D. students at
UNC Chapel Hill, in August 2016
Executive & Strategic Team Member of Child Rights & You (CRY) IIT Kharagpur Chapter (2011-2015) Worked on
implementation of the provisions of Right to Education (RTE) Act in rural public schools and abolishing child labor near
Kharagpur, India (2011-2015)