Minimization of Bleeding Ce. €) @ lichagpneveivical-trial-registryMCT02615366 oa ICH GCP xs mune Good Clinical Practice JSQA CR Mirimization of Bleeding Co... €) @ lichagpneveivical-trial-registryMCT02615366 Intervention Type Intervention Name firm Group Label Criteria Drug © Placebo Placebo Control Inclusion Criteria: = Patient requires and is 3 candidate for any ¢ Reduction mammaplasty, mastectomy with an implant-based reconstruction, oncoplastic bre - Patient has OHIP approval for surgery. = Patient is willing and able (je. Englishy/Frencl read and complete patient diaries, demograp! followed-up for a 2 weeks, 6 weeks, 12 week Patient is 19 years of age or older Exclusion Criter Patiant is allergic to tranexamic acid ~ Patient has a history or present laboratory « platelet counts. prothrombin time, partial throMirimization of Bleeding Co... (©) @ | ichgepnet/cinical-trals-registry/NCT02615366 - Patient has reduced renal function with plas - Patient has haematuria - Patient is currently using a form of birth cont Mirimization of Bleeding Co... (©) @ | ichgepnet/cinical-trals-registry/NCT02615366 PMID Citation PMID Citation PMID Citation PMID PMID Citation 21915085 Carpelan 4, Kauhanen 5, Mattila K, Jahkola T, procedure: a retrospedive enelysis of outcor Jun; 104(2):96-102. doi: 19.1177/145749691- 24809356 Xu Q, Yang ¥, Shi P, Zhou J, Dai W, Yzo 2, Zhan offactive and safe at reducing perioperative b 3un;8(3):159-75. 25030852 Gillette 8P, DeSimone LI, Trousdale RT, Pagnat with tranexamic acid after primary total hip ar Jan;47 1(1):150-4, doi: 10.1007/s1 1999-012. 22814857 OertliD, Laffer U, Haberthuer F, Kreuter U, Ha reduces the local wound complication rate aft 3un;81(6):856-9. 9044502 Moher D, Hopewell §, Schulz KF, Montori V, Got ‘CONSORT. CONSORT 2010 explanation and el randomised trials. Int J Surg. 2012; 10(1):28-: