(20/n/20%0 ) Gastromrestnal drugs 1 prugs for pephe ulcer The parhogenesi® of pepnc ulcer vociuder * - inf with GC-Ive HW pylor _ # HCI secre non - adequate mucosal oefense agamsh gasme acid Treatment of pepe ulcer are 1) Eradscaron 4-pylon inP. _® Reductron oF gasinc acid secreHon 3) Ha antihistamine : Crmendine »Ranincune 4) Aicholinergic : Atropine, piwrenRepme 5) Pros tagiandin anatog > mesoprostel ® provon pump ind. * Omeproxole ® neutraigaon gasire acid Canraaid) 8) 908. Codium brcarb. yy nron-0ys > MgCona fA AICO; , Carrum card 70) ulter protechre : Sucralfote.=| Stecorspy exadicatron HW pylon C#O-90%) Combinahén gnsmicrobial drugs = Treatment with a single antmerobial drugg 1S 1 eHechve C20-#0% ) eradicahon rater . 2) Regulating of gaswric acd seciepgn Ne a ' | Gatine aad secrenon by panera eps oF gathrt mcora " Controupe uy: 1 = gastn hastaming $ ACH CH gasme acid secte tion): Poe, eaf2 — F PGE2 > PGIa CH aad prod.)aaverse e ec ~ headache ~ dezzmess - diorkea / cons mpaton ~ muscular pain ~ dry mouth rashes ~ confusion y,rectiesmesr Cmay be nallucin avons) Cimt ding 1) T+ was me 1% H2 bicker to be miroduced Ciniealy + 40 descrised as prototype 2 It has Chu nor orher 2 blockere) @MMandrogenie achon- sigh doses given For I0ng perros hore pro. gynecomastia » tose of tibvdo »/mpotene + ¥ cpecm count 3 may. cause. rewtropenia 4D Can iRb. cytochyma P-#60 can Sire Slow met. of Serera! airag® Ranth dine 8 mes mare potent. than. Cimboline. > hee longer, duration of achon C14 he -but Cimindene hes HHS hrs) SMe Aatiantlrogenc achon. no effect 2 $. Seruar funct — / gynecomastia.~|has lower permeability ‘nto brain lower propensity to Cte” om Omi ~ 1 doos not significantiy ib hepahe met of other drugs - Phe overas imeicene of side effects % lower : heaclache 2 Garrkegy constipation » dhkwnets >have mecknee cmilap fo plawbho 5) _Antimuscannic agents Atropinic tugs ¥ vol of gash juice wlio T pH Pirenzepme D js @ specie Mi-recep. antagomer Ca stiechre Mi- antehpurergie nny: ) DA gasme acid secrehon at doses Aaving & munumal eect on SUlrend ond 5 "hewt + eye Cm contray 10 com: pene) 3) doer noF prod. ews effects. °) _Prostaguandin Ex + Ta = are prod: in gasme mucosa + appear to serve prorectve role by ep inion mhibiting Secrehon + promoting mucus + bicarbonate cecrenth. ear | Year prod + pos hove Qn inde fred ~ tytoprorechre” acto by » | 2 {= PRMONNG “Tegeneranon (4 ONA tontenn. of dng. gone mercosa) a tyea micoproste!. ~ analog of prostagianelun Ey ~ eurrentig the only agent approved by non-steroidal anh- inf tammatory yess efechve than for prevention OF gasine wicers agents Ha BMASnG ts” for atule »degpmiannh gt pepiia lle Ahough t+ has Cyfoprot aehens. ~ olintcaity efechve only at higher dotes that diminish gartre aceel cecrehon. — contraindicated lug pregnancy - adverse effects = nausea + cMarhea DD Intvorors of Ht /K+ ~ pe ATPase proton pump ~ Arg + omeprorole - It i$ Me Arsr Of 2 new. ciase of drugs thai pinds to wt/At - A Teac enz. system Cproton pump) of panetal cell » block * + suppre secrenon Hr mo gactre tamer. membrane. bound proton. pume i$ Anal sep ™ secrenon of gosimé uses Omeprozole 1s used for shart teem Heatmen+ of tronve esophagits +. achve duodenal utcer + Pr long Hearmenr oF patheloge hyperrecrefory _eendstons avere effect ~ — omeproxo/e we generaity we _ foferaied. induced_ B) Antacids. ~ They are bacie Subs. whith v gashrc aucty + reduce achviry Checause pepir ypocwe or po >H-o) =| They don’t y aed prod. Uses: duodenal wars —— acute gathye uler : i ” ee Sodium bicarbonate - ee oe may cause sys. adkalont . T+ 8 wtwany not @ prob ‘% patents with notmai renat funck. » but con be an MP ORNS cope decoton in parents — with hypertension or congestve heart Farture a) it (prod: Coz in samach “Cteuecor sarstenhion 5 diccomfort 4 ‘Ss | PERT OF “utter perforahon ) 2 a F Nor toad: Moy women -edemo Ccenmarncucated 1m comme Re eetord F sindehvere pepe: moy prod. diarrheaAr cow). 1) bland, weak + slow reachng antacict ® adsors + mochvate pep. 3) may relax Smooth musctie ¢ may be AP ahng Calcium carbonate 1) @ pont # rapidly achng antatd 2) prod 02 im Stomach Csimitar Nancor) + cause feito + decom 3) Cat party absorbed : hypercaicema , pypercaiccur ko 4 formanon of Calcium stones. m. kidney can occu» en tong fern use F) Mucosal prorechye _ ogent ~rug : sueraiPate creas a physical gamer thar smpaires di. of ACL + prevent olegradahon of mucus by pepsin - alto etrmurates —proctagiandin rerease + mucus + bitarbonate| output + mb. poppe aligention chvely Aeoll duedenal ~ by phese + many ether mech. .» Sucral fate ulcer 4 if used th Jong- term. maintenance therapy te prevens Herr Pecwrence . a vell tolerated 4Emec and anhemerc drugs erate and Bnhemene args: 12 Emene drugs : ~ acp on Czr Cchemorecep. tigger zone) Apomorphine = = act refiexly and on C#T Tpecacuanha ~ vominng need® 49 be inducecl only when an undetirante 9" Substance Cpoison) hos heen ingested - @ Apomomphune = Semisyrtrenc denvahve of Morphine ~ acre as dopaminergic agonst on czt ee OE I 5 wim Wore. oF OMG» hep ¥ vomutng eoused AF yeep. chepresred LR bmi) mittens 2 ae 1 has pomp 4 ous oo Merestant actrons.1) coroswe Cacil, aleal’) porsoning 2) CNS Omuant drug powenng C may be Convuisions ) 5) morphine & — phenothiak ine poronsng = emehe ine fechve 2) Anhemahe drug?’ Meroctopromide C Ceruca/ ) = blocke Aa- dopamine ecep. of tH7gGer Zone + mb. vomibng | + nausea ~ Adverse efectr + sedaton diarrhece Cxtropyramictial syorp. (mest Common in younger patents !