Glucosamine Evidence Based Review

:Guidelines
: NICE guideline Sep , 2016 -1
DO NOT offer glucosamine or chondroitin products for management of
osteoarthritis
American College of Rheumatology 2012-2
We Conditionally recommend that patients with knee OA should NOT USE
Chondroitin , Glucosamine
:Cochrane Systematic Review 2005 -3
Pooled studies using non-rotta preparation failed to show benefit in pain and
WOMAC function, while studies evaluating Rotta preparation showed that
glucosamine was superior than placebo in treatment of pain and function
impairment resulting from symptomatic OA
The European Society for Clinical and Economic Aspects of Osteoporosis -4
: Feb 2016
Only the patented crystalline glucosamine sulfate (pCGS) formulation
(Rottapharm) has proven efficacy in the treatment of OA

Therapeutic Advances in Musculoskeletal Disease Review 2012-5

Crystalline Glucosamine sulfate is the original glucosamine product that has shown
efficacy and safety in Clinical Trials in knee OA when used at the dose 1500 mg once
daily. Other glucosamine products are available in different formulations or other salts
or with varied dosing regimens have never shown to be effective in clinical trials not
bioequivalent with crystalline glucosamine sulfate. The latter is the only glucosamine
product recommended by current clinical guidelines
: Pubmed : PEGASus study-6
Crystalline glucosamine sulfate was the only SYSADOA that decrease the use of
NSAIDs in patient with knee pain

Systematic Review published in ACR/ARHP Annual meeting: Sep 2016 -7

Glucosamine sulfate (Rotta Form) is the only effective in long term treatment of OA
-:The Total Cost expensed in .. hospital on glucosamine is -8
:Conclusion******
The USE of Glucosamine Rotta formula (1500mg once may be Effective in OA
management , The use of all Glucosamine Form that present in Egypt is With
NO Significant effect This Review Date : March , 2017 BY: AmrMedhat