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Discussion
Spontaneous hemorrhagic stroke in
young people ( aged <35 years) has been
estimated to be 0.5/100 000 and few series
of intracerebral hemorrhage in young
people have been published.
Ruz-Sandoval et al, 1999, analyzed 200
patients aged < 40 years, among 1734
consecutive patients diagnosed with
hemorrhagic stroke. They found that the
most common risk factors included tobacco
use in 20%, hypertension in 13% and B
alcohol use in 10%. Also they found that Figure 3 A, B MRI of hemorrhagic stroke in right
occipito-temporal area
the most common locations of intracerebral
hemorrhage were lobar in 55%, basal
Fuh JL et al, 1994, evaluated 170 patients
ganglia/internal capsule in 22%, the brain
aged 1545 years who had nontraumatic
stem in 26 (13%), cerebellum in 10 (5%),
hemorrhagic stroke and they found that the
intraventricular in 4%, and multiple in 3
main causes of spontaneous intracerebral
cases. The most common causes of
hemorrhage were hypertension, ruptured
intracerebral hemorrhage were rupture of
arteriovenous malformation and blood
an arteriovenous malformation in 33 % of
dyscrasia. A cause was not found in 42
patients, cavernous angioma in 16% of
Romanian Neurosurgery (2011) XVIII 3: 294 299 297
patients (24.7%). Also they found that with other studies that show cryptogenic
young adults with nontraumatic intracerebral hemorrhage in 15% of their
intracerebral are a heterogeneous group and patients, but the number of our cases is
hypertension accounts for about one-third small.
of intracerebral hemorrhage and it is an Risk factors for intracerebral
important preventable cause of hemorrhage are known: age and race;
hemorrhagic stroke in young adults . hypertension, cerebral amyloid angiopathy,
We evaluated 191 patients diagnosed arteriovenous malformations, alcohol use
with hemorrhagic stroke and young adults and tobacco use.
with nontraumatic intracerebral Age is the greatest risk factor for
hemorrhage were only 8 cases and the main intracerebral hemorrhage. Incidence rates
cause of hemorrhagic stroke in young increase dramatically among persons older
people was high blood pressure (for 5 than 60 years. Hypertension is the most
patients). Therefore arterial hypertension is important and prevalent modifiable risk
an important preventable cause of factor for ICH. Untreated hypertension is a
hemorrhagic stroke in young adults. greater risk factor than treated
But in other series with large number of hypertension, and hypertensive patients
patients hypertension was responsible for a who discontinue their medications have
low percentage of intracerebral hemorrhage greater risk than those who continue them
and compared with other causes, this Cerebral amyloid angiopathy is now
produced the worst outcome and resulted considered an important cause of lobar
in high morbidity, mortality, and hemorrhage in the elderly.
recurrence. Hypertension as a cause of Aneurysms and vascular malformations
intracerebral hemorrhage was most are particularly important as a cause of
common in individuals aged >31 years and intracerebral hemorrhage among young
the intracerebral hemorrhage was often people, although in our series the rupture
located in the basal ganglia. of an arteriovenous malformation was
We found only a case of intracerebral found only in one patient. Antiplatelet
hemorrhage caused of the rupture of an drugs probably increase the risk of
arteriovenous malformation, but in other intracerebral hemorrhage by a small
series the most common cause of amount. The absolute risk of intracranial
intracerebral hemorrhage was rupture of hemorrhage among elderly persons taking
vascular malformations, including both aspirin has been estimated at 0.20.3%
arteriovenous malformation and cavernous annually (vs. 0.15% in similar persons not
angioma. The most common location of taking antiplatelets or anticoagulants).
intracerebral hemorrhage resulting from Numerous studies have identified a
arteriovenous malformations was lobar. relationship between alcohol use and the
Cavernous angioma was most commonly risk of hemorrhagic stroke and also several
located supratentorially but was the most studies suggest that current smoking
common cause of intracerebral hemorrhage increases the risk of intracerebral
located in the brain stem. hemorrhage .
Cryptogenic intracerebral hemorrhage Spontaneous intracerebral hemorrhage
was considered in two patients, compared causes 1015% of first ever strokes and is
298 Spyridon Roditis, Nicolai Ianovici Hemorrhagic stroke in young people
associated with the highest mortality of all Surgical therapies have been unable to
cerebrovascular events. The initial improve the neurological outcome of the
diagnostic question in a patient with acute patients with intracerebral hematoma and
onset of focal neurological deficits is to minimize brain tissue trauma that is
whether or not the deficits are caused by induced by surgical manipulation, and in
intracerebral hemorrhage . The answer is of view of the failure of craniotomy/hematoma
utmost importance in determining the evacuation to improve survival and
direction of treatment. Non-contrast CT is neurological outcome after intracerebral
the first-line imaging modality in this hemorrhage, new modalities as minimally
setting. Computerized tomography scans invasive surgery (MIS = e.g., stereotactic-
are rapid, readily available, and relatively guided aspiration) have emerged as
inexpensive. Most importantly they have treatment alternatives that are amenable to
exquisite sensitivity and specificity, testing. Studies testing the safety and
approaching 100%, in the detection of acute efficacy of minimally invasive surgery
blood. techniques in the treatment of intracerebral
Because hypertension is the most hematoma have taken advantage of mainly
common cause of spontaneous intracerebral two different procedures: the use of
hemorrhage, its treatment in this setting is endoscopic aspiration of the hematoma and
of considerable importance. the stereotactic placement of a flexible
Intracerebral hematoma growth may be catheter in the core of the hematoma
accelerated by hypertension in the setting of followed by the administration of
acute intracerebral hemorrhage. The thrombolytic agents. Both approaches are
occurrence of intracerebral hemorrhage is viable treatment alternatives of craniotomy
strongly related to premorbid blood in hematoma evacuation . Clot evacuation
pressure; however, the relationship between combining the use of fibrinolysis with clot
the growth of hematoma and uncontrolled aspiration has emerged as the most
blood pressure remains to be clarified. promising surgical modality in the acute
Jauch et al demonstrated that there was care of intracerebral hematoma.
no definitive correlation between
hemodynamic parameters,such as blood Conclusion
pressure and hematoma growth. The recent Arteriovenous malformations are
studies emphasize aggressive blood pressure particularly important as a cause of
control for a systolic blood pressure >200 spontaneous intracerebral hemorrhage in
mmHg or mean arterial blood pressure young people intracerebral hemorrhage,
(MAP) >150 mmHg . For an systolic blood although in our series the rupture of an
pressure >180 mmHg (or MAP >130 arteriovenous malformation was found only
mmHg), with a suspicion of elevated ICP, in one patient.
ICP monitoring is recommended; on the The use of non-contrast CT in the
other hand if ICP elevation is not a concern initial evaluation of patients presenting with
based on the patients neurological suspected intracerebral hemorrhage is well
examination, a goal of systolic blood established and universally accepted.
pressure <160 mmHg or MAP <110 Because hypertension is the most
mmHg is recommended. common cause of spontaneous intracerebral
Romanian Neurosurgery (2011) XVIII 3: 294 299 299