10/10/2011

Patologi Sistem Endokrin

Dr. Devy Ariany, M.Biomed

Kelenjar Pituitary

Asidofil Growth hormone, prolaktin

Basofil TSH, ACTH, gonadotropin
Kromofob

10/10/2011 dr. Devy Ariany, M.Biomed 2

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Pituitary adenoma Makroskopik

Massa tumor dengan titik

hemoragik
Batas jelas
Tumbuh ke arah ventrikel
lateral sinistra
Proliferasi seluler
monomorfik
(uniform)
Difus

10/10/2011
Mikroskopik
dr. Devy Ariany, M.Biomed 3

Kelenjar
Pankreas

Asini pancreatic enzim cerna

Pulau Langerhans
10/10/2011 dr. Devy Ariany, M.Biomed insulin, glukagon
4

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 10/10/2011

Makroskopik
NIDDM

Aterosklerosis aorta

Diabetic nephropaty

Funduskopi : area edema, fokus

10/10/2011
hemoragik, neovaskularisasi
dr. Devy Ariany, M.Biomed 5

NIDDM

Mikroskopik

Asini pancreatik (eksokrin) normal

Pulau Langerhans (endokrin) tampak
deposit amiloid

10/10/2011 dr. Devy Ariany, M.Biomed 6

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Kelenjar adrenal

Simpai, korteks, medula

Hormon kortikosteroid

Adrenalin & noradrenalin

10/10/2011 dr. Devy Ariany, M.Biomed 7

Feokromositoma Makroskopik

Massa padat abu-abu

Massa tumor Batas jelas
menekan
korteks
Berupa
sarang2 tumor
dikell pleksus
kapiler
Fokus nekrotik
10/10/2011 dr. Devy Ariany, M.Biomed
Mikroskopik 8

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Kelenjar Paratiroid

Chief cells h. parathormone

Regulasi kadar kalsium darah

10/10/2011 dr. Devy Ariany, M.Biomed 9

Parathyroid adenoma Makroskopik

Nodul coklat, lunak

Fibrous Dilapisi oleh selaput
pseudocapsule yang jelas
Chief cell
sarang tumor
Nukleus uniform
Mikroskopik

10/10/2011 dr. Devy Ariany, M.Biomed 10

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Kelenjar Tiroid Thyroid Glands

F : The follicles
S : The septa

Folikel tdd : Regulasi

Sel folikuler T3 dan T4 pertumbuhan
Sel parafolikuler/ C cell dan
kalsitonin metabolisme

Regulasi kadar kalsium

darah
10/10/2011 dr. Devy Ariany, M.Biomed 11

TIROIDITIS Makroskopik

Pembesaran asimetris
Folikel rusak Kapsul utuh
Parenkim Berwarna kuning putih
penuh sel radang
kronik (limfosit,
histiosit, sel
plasma) Mikroskopik

10/10/2011 dr. Devy Ariany, M.Biomed 12

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TOXIC GOITER Makroskopik

Pembesaran simetris
Sel
Kapsul utuh
hiperplastik
Lunak seperti otot
Folikel
dilapisi oleh
sel epitel
kolumnar
Koloid penuh Mikroskopik

10/10/2011 dr. Devy Ariany, M.Biomed 13

FOLLICULAR ADENOMA Makroskopik

Pembesaran asimetris
Adenoma tdd Massa soliter merah
sel kuboid kecoklatan
hiperplastikdgn Berkapsul
pola tubular

Mikroskopik

10/10/2011 dr. Devy Ariany, M.Biomed 14

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FOLLICULAR Thyroid ca. Makroskopik

Pembesaran asimetris
Massa coklat muda
Folikel dibatasi Nodul dengan fokus
sel epitel hemoragik
hiperplastik,
pleomorfik,
hiperkromatik
Invasi vaskuler
Mikroskopik

10/10/2011 dr. Devy Ariany, M.Biomed 15

PAPILLARY Thyroid ca. Makroskopik

Pembesaran asimetris
Folikel dibatasi
Massa coklat muda
sel epitel
Nodul dengan fokus
hiperplastik,
hemoragik
pleomorfik,
hiperkromatik
Invasi vaskuler

Mikroskopik

10/10/2011 dr. Devy Ariany, M.Biomed 16

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10/10/2011 dr. Devy Ariany, M.Biomed 17

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