C SANTO TOMAS-FACULTY OF MEDICINE AND SURGERY MEDICAL BOARD REVIEW 2017 MOCK BOARD EXAMINATION-BIOCHEMISTRY 09, 2017, Wednes SET A NAME:_ SIGNATURE: GENERAL INSTRUCTIONS: This ¢ re is compose .MINATION ANSWER SHEET provide 1 blanks as this on perties-of are-called epimers anomeric carbon atom odiester ban and glucos 0 acids is classified as atiphatic with non polar side 0 acids structure :-ala- glu-lys- arg, Which of the Following is zero at physiologic pH & when separated by electrophoresis tp 8.5, wil migrate to the cathode The quaternary structure of a protein refers to the: A. amino acid sequence of the polypeptid. local conformation such as alpha helix or beta pleated sheet ¢-dimensional conformation of a polypeptide ts in-a protein containing more than one 6. This_glycosaminoalycan consists of repetit " alycan consists of repetitive units composed of L-Iduronic acid vicD-Galactosamine forms and accumulates in Hurier’s Syndrome: B. Hye C. Dermatan Sulfat D. He UST-FMS MEDICAL BOARD REVIEW 2017 Page 1 of a2talyze the same chemical reaction feactions at the samme reaction rates ures catalyzing the same tate opposing chemical th imary and secondary true about coenzymes? 2 m water soluble vitamins organic portion of the enzyme fe megalablast ndition? base catalysis ‘anemia. Which following reactions is ‘an exergonic react 9 the Following is true? reaction to completion ss than Zero in order to proceed 5. Oni on diffe substrate level phosphorylation in which of the A, Oxidative phosphorylation thesis of energy upon the transfer of high energy phosphate group to ADP 8 Phosphorylation occurs exclusively in the cytosol Oxidative phospho tion Is formation of ATP coupe with transfer of electrons along the lectron Trensport Chain D. Substrate level phosphorylation is characte oytoplasm N OF substrate in the UST-FIMS MEDICAL BOARD REVIEW 2017 Page 2 of 12Insevere his garage in an unconscious state in sev ine was running, He was brought to te emergency room but was carbon monoxide poisoning. Carbon from phosphory e ETC tory Chain ion leading to thelr lr The activity es may be regu phosphory activation or ina node of regulation is called: D. Covalent modifica 2,18. By increasing th 7 yond optimum and decreasing the pH, the reaction r he following possibilities EXCEPT 19, Cell tribute to energy production because cellulose 2 average diet ed of glucose ictose and galactose he enzyme to hydrolyze beta glycosidic bonds of cellulose A. consti . man does not hat nto the cell, immediately undergoes this biochemical process f energy: uate and acetyl CoA to glucose 6-phosphate B. recya its carbons for nucleic acid synthesis AA 21. Which statement is true regarding Hexokinase and Glukokinase ? ‘A, Hexokinase has a lower affinity for Glucose compared to Glucokinase B. Hexokinase is inducible by insulin CC. Glucokinase wil phosphorylate glucose molecules moré readily than hexokinase . Glucokinase js subject to product inhibition by ts product Glucase 6-phosphate C, 22, A molecule of glucose when metabolized via the Embden Meyerhoff pathway: {generates 2 molecules of pyruvate. because of this enzymatic reaction: A phosphofructokinase-1 8. aldolase b C. phosphotriose isomerase ate kinase cles and the erythrocyte produce this product of glycolysis A. pyruvate B. acetyicon C. lactate D. glucose 6 phosphate B 24. Which of the following reactions is considered the major anaplerotic reaction and an initial ~~ teaction for gluconeogenesis ? A, Pyruvate dehydrogenase B. Pyruvate carboxylase Cilactate dehydrogenase . Pyruvate transaminase UST-FMS MEDICAL BOARD REVIEW 2017 Page 3 of 12 ireogenesis , EXCEPT ‘an contribute to gl 25. All of the following Gitric Acid Cycle, EXCEPT? wing is of th i. oxidative phosphoryl ducing coenzymes NAD and FADH2 f lepine Se decarboxylation of pyruvate to acetyiC ee ne of ATP tha cube hasphorylation enerates 3 molecule of ATP thru substrate level hosp final common pathway of intermediary ated with Complex IT of the Electron 7 ‘Transport Ch medication, Several hot is enzyme might sth ‘kinase D, Glucose 6-phospt 1. The Uronic acid pathway wydrogs i important in metabolism In’ man because it ycalysis that provides @ greater amount of energy Ids for glycosaminoglycan synthesis and conjugation of . generates metabolites for the synthesis of fats and proteins 32 Epinephrine and glucagon can cause hyperglycemia by which of the follo A. breakdown of muscle glycogen to glucose B. activation of liver glycogen phosphorylase C. promoting glycolysis and inhibition of gluconeogenesis D. inactivation of cyclic AMP- dependent protein kinase ing mechanism? ‘Giycogen metabolism in the liver differs from that in the muscle because inthe liver, glycogen: ‘A. is degraded to provide Glucose 6-PO, for its exclusive use B.is synthesized from Glucose 1-PO, C. maintains blood glucose levels during short periods of fasting . stores glucose mainly for glucuronic acid formation 74 Fructose when metabolized by fructokinase , enters the glycolytic cycle as A. Fructose 1,6 bisphosphate 8, Fructose 1 phosphate C, glyceraldehyde 3 phosphate D. Dihydroxyacetone phosphate UST-FMS MEDICAL BOARD REVIEW 2017 Page 4 of 12sous state «brought to the host ip suporous st z 1s showed elevated ammonia leve is and Fre" pmmary cause of his mental satus derived from glutamate and ons can be metabolized into transamination? served to be lettre i nd eventually de urine that is cher asional seizures gradually Initial laboratory findings ‘before death show terized as sweet smelling similar to maple syrup. no acids is involved with this cont ‘A. Sulfur containing amino acids €. Branched chain amino acids it was Seen in the ci ic because of skin lesions and diarrhea. The pellagra like manifestations may be seen in de y of this essential amino acid: A Phenylalanine ich of the folio ng amino acids can contribute most D. Alanine UST-FMS MEDICAL BOARD REVIEW 2017 Page 5 of 12os the fate of Triacylglycerol molecules stored in adipose d from adipose tissue into the plasma as components of portant direct source of ipase is phosphorylated and activated by a cAMP-activated protein of fatty ac ompor Gs stored in pose: is formed by phosphoyriation of glycerol by glycerol Kinase B. ATP is requi (FFA) to aly brain where they are u D. FFA are b hormone-ser 1. An infant, born at 28 gest apidly gave evidence of respiratory distress as shown by Lab and x-ray results. Which of the following statements about Respiratory Di Syndrome (RDS) Is true? {i concentration of dipalmitoyiphosphatidyicholl would be expected to be than that of a full-t 2 UST-FMS MEDICAL BOARD REVIEW 2017year old girl was braught to the Emergency Room at Sam because of severe in. A blood was taken and was found to be milky in appearance. The 3 triacylglycerol level in excess of 2,000 ma/¢l (normal = 4-150 maid). The patient wass piace 2verely limited in fat, but supplemented with medium-chaln fatty acids. ¢ the following lipoprotein particles are most ikely responsible for the appearance of the td ste oF the pathway 1uvalents for the enzyme Fatty sis Is stearate iS differs from fatty acid oxidation in that the farmer: mitochon dria id FADH ated by receptors e by Apoprotein C-Il ‘tivation of the hormone-sensitive lipase of phospholipase A Which statement regarding ketone bodies is correct? Ketone bodies cennot pass through the blood brain barrier The liver is unable to use ketone badies as energy source Ketone bodies is packaged in VLDL D. Ketone bodies can be produced from gluense Poprotein synthesized in the liver contains a high concentration of triacylglycerol sd from the circulation by adipase tissue and muscle? A. Chylomicrans B.HOL VLDL D. LDL 58. A 40-year-old woman presents with an LDL serum level of 400 (N.V. <130), and a triglyceride level of 170 (recommended level is <150). She is dlagnased with type II familial hypercholesterolamia, In this disorder, a mutated LDL receptor is bind to LDL. Which of the following would result? A, Cellular HMG-CoA reductase activity is not inhibited. ides in chylomicrons cannot be degraded, el in the serum increases. D. The HDL level in the serum increases. formed, such that it cannot LUST-FIMS MEDICAL BOARD REVIEW 2017 Page 7 of 22A 60. Statins are competitive inhibitors: of HMG-CoA reductase, which converts HMG-CoA to: A. Mevalonateli} 8. Isopentenyl pyrophosphate . Gerany! pyrophosphate , choteatere for myocardial infarction clue to its cardioprotedt nase activity which Is required for the conversion jal treatment inhibits cycloox 61. Aspitin is gi ‘As a NSAID, as A. Thromboxanes from arachicionic ac B. Leuk« from arachidonic acid C. Phosphoi om arachidonic acid D. Arachicionie acid from linoleic acid ing products , EXCEPT Af 82. Complete hydrolysis of sphingomyelin ylelds all of the AA. sialic acid ‘©. phosphab 1 is chaarcterized by accumulation of Which of the following Inbom error of lipid metab "2 ganglioside? Niemann Pick Disease B. Tay Sachs Disease €. Gaucher's Disease D, Fabry’s Disease 64, High serum HDL levels are protective against the development of atherostlerosis because HOL: AA. Inhibits cholesterol production by the liver B. Inhibits HMG-CoA reductaselii ©. Increases LDL production D. Brings cholesterol esters bad the liver [/ 65. 12-year-old boy presents with Fatigue, polydipsia, polyuria, and polyphagia. He is diagnosed with type 1 diabetes melitus, Which one of the folowing is most likely oceurring in this patient? A. Increased fatty acid synthesis from glucose in livers] B. Decreased conversion of fatty acids to ketone bodies C. Increased stores of triacylglycerol in adipose tissueli) D. Increased produ tion of acetone Pecan ctarcin form because of acastiation of us suger alcohol in the lens of the eyes: A. Mannitol B. Maltitol €. Xyitel D. Sorbitol 67. A normal person takes in a high carbohydrate meal and decides to fast thereafter. Which of the following schemes most accurately depicts the order of the metabolic processes in the liver? A. Glycogen synthesis, lipolysis, gl luconeogenesis, glycolysis 8. Glycolysis, alycogen synthesis, lipolysis, lycogenolysis, gluconeogenesis C. Giycogen synthesis, alycogenoiysis, lipolysis, gluconeogenesis D, Glycolysis, lipolysis, gluconeogenesis, glycogen synthesis UST-FMS MEDICAL BOARD REVIEW 2017 Page 8 of 12fhe emergency foom in an unconscious state. The vas browch to the emergene on 8 aca roel Ue or sstered ravenous gen and oie which rea ONG sory ace calanio bolic response is 2m of fuel is correctly described by this staternent: y obtained from the oxidation of Fue ‘eohydrates than fats rotein than carbohydrates and fats n than adults, tion for an avera Filipino adult , which of the following equirement must be based on the individual actual body hydrates, proteins and fats must be 60° 15%, and C-To lose one pound a ™ust subtract 1000 kcal per day from the total ‘must constitute 2n additional 50% of the basal UST-FMS MEDICAL BOARD REVIEW 2017poribosy! transferase Xanthine Oxidase Adenosine deaminase r to decrease blood ur te its urinary excretion bolism nd excretable form ity. of uric acid and prom duction thru anaerobe glycols PH NADP ratio allostercaly activates xanthine oxidase 83. rugs e.g § fluoro ura ) A. inhibiting synthesis of DNA B. alkylating bases.in DNA intercalating double stranded DNA denaturing DNA 34, Which of the folowing statements is correct about gene expression? A. DNA replication in eukaryotes is conservative 8. Reverse transcription in eukaryates is possible Transition i the transfer of genetic information from DNA to RNA DT he final products of gene expression are always proteins UST-FMS MEDICAL BOARD RE 2017 Page 10 of 12ay no cause any phenotypic change a point mutator se any ide which of the following n exhibits @ type of regulation by: ollowing takes plece during gene gene product exerts its anti-tumor effect by inhibiting e jasma in that serum levold of clotting factors roup UST-FMS MEDICAL BOARD REVIEW 201 Page 11 of 12 ie94. He 'k. Hemoglobin a 8. Binds 1 OF ation curve te al because fetal : wound healing by which of the fol UST-FIMS MEDICAL BOARD REVIEW 2017 Page 12 of 12