1

1. 1mm/d 4+2
=
2.
3. = =


4. = 5+5=
,
12
5. - = 1
6. 36 LMP 5.
7. . crl= 2-4mm =16-20mm
8. 5 9 110-175
9. doppler
10. ISUOG=CRL
a.
b.
c.

. .
GS 4 2mm 5 10mm .

10mm=GS
YS 5 2mm 6 3mm
2-3


1 10
. 5+4 70bpm 6+4 110 6 =
100-115
crl 5+3?? 3mm 6+3 4-9mm
7 7 E=10-15mm

11. Crl(mm)= +6,5

12. = 5
a. 6
b. 8 .
13. =
a.
b. 7% 20
c. 1
14. =
15.
a.
b.
c.
d. / >6mm
e. /
f. ..
 g.
h.
16.
a. CRL>7mm
b. GS=25mm
c. >2 .

d. .. >11
e. = 1
17. .. 1 = CRL= +/- 5
a. 8-14
b. 11-14= crl BPD
c. . crl 84mm- HC
b. IVF= = .
1. =
2.
a.
i. -

2 =

1. 15%
2.
a.
b. >1cm
c. <5mm
d. ,
3.
a.
4.
a.
b.
5.
a.
b. = ,
c.

3- -

1. =
1. 5-25mm
2. 6= 4-9mm
3. 7= E 10-15mm
4. hCG
a. 3=100-1000
b. 4=1000-1500=
c. 5=1500-5000=
d. 6=5000-7500=
i. 48
1. >66%
2. >15%
 3. =
5. -
a. > 5mm
b. >8 mm
c. >16mm
d.
i. <20mm
ii. <6mm
e. us 1
6.
a.
i.
1. 3
a. 1
b. 2
c.
d. =11-14
e.
ii.
1. 2
2.
3. 2
b.
i. =
ii.
iii.
iv.
c. 1-2/1000
d.
i. <20 >40
ii. 1%
iii. =
iv. =
e. +
i. 1/20.000-100.000= 40%
7.
a. = 1-5%
b. = 15%
i. 2%
c. - =50%
a. 50% =
8. hcg
a. 1-2 3
b. 1-3 6-12
9. 6-12
10.
11.
a. bcg
i. <10% 4/3
ii. >10% 3 >> /2
iii.
 iv. hcg>4-6
v.
vi.
vii.
viii.
ix. 100%

1. RT= 22
a. 100
2.
a. / <37 60%
1. / 80-90%
ii. 4,6% /
i. 5,2% /
3.
a. 33%
i. 33%= 0-3
ii. - 65%=3-9
iii. --=2% 9-12
iv. 12-15
b. 67%=
4.
a. Us-
i. 6-9
ii. 11-14
iii. 16
b.
i.
ii.
c. =
d. = 2
e. >20%
i. 25%
1.
2. TTTS
f. TTTS
i. - 15%

ii. laser
1. 60-70% 2
2. 80-90%
g.
i.
1.
2.
3. 2-3%

5 1
1.
a. 2

b. 1 . 11

c.
2.
a.
b.
2

c.
i.
ii.
iii.
iv.
d. 6%
3.
a.
b.

c. 18
d.
e. 2
f.
4.
a. -
b. -
c. 80%
d. 20% .
e.
 8

1. 21 hcg= 2 M PAPP-A=0,5 M
2. T18 0.2 0.2
3. T13 0.3 0.4
4. Turner 1.2 0.5
5.
a. 0,2 0,1
b. 9 0,7
6. 1
10-20% 11
7. =
/
a.
i. 1,5-3%
ii. 6-10%
8. DNA
a. cffDNA

b. 21,18,13 /

c. scrrening
9. =
95% 2%
10. 2 = 96% 3%
11. = 0,1-0,2 %
12.

a. 0,7-1,7%
b. 6-10%
13. cffDNA= 21 99,9% 0,06%
5-7%
14. SCENARIOS OF NIPT
a. screening 1 =cfts
b.
15. NIPT cfts
a.
b. cfts
c. NIPT 2 cfts
i. <1/150
ii. 1/150-1/1000= cfDNA
16. 21 100.000
a. .>35
i. 50%
ii. 20%
b.
i. 80%
ii. 5%
c. = ++PAPP-A+BCG
 i. 90%
ii. 5%
d. NB( )+ +
i. 95%
ii. 2%
17. NIPT 21-13-18 4

18. = 1/300
19. 1/300
20. 1/300-1/1000 NIPT
21. <1/1000
22. 1-2

9 SCREENING IUGR

1) GUIDELINES 2015 NICE-ACOG

a)
i)
ii)
iii) sle aps()
iv) 1 2
b)
i) 1
ii) >40
iii) BMI>35
iv) >10
v)
vi) ivf
c) FPR=67%

10

2) 15%
3) 3%
4) 10-14
a) = 11 142
. . /
7 11 .
131
b)

c) /
,

d) ,
99% 30%
e) 44% >95%
i) 20% >99%
f)
3,5mm
 g) o us 20-22


h) 1 5
.
. us 20
, ,

i)
/

j)
//

k)
,

i) Noonan syndrome
ii) Di George
iii) Spinal muscular atrophy
iv) Smith lemli opitz
v) Congenital adrenal hyperplasia
l) To noonan syndrome -

m) /
,
=essential
n) 2 Us
,

o) 9-16%
p) Us
i) Distended jugular lymphatic sacs
ii) Hydrothorax
iii) Renal anomaliew
iv) Polyhydramnios
v) Cystic hydroma
vi) Cardiac anomalies
vii) Hydrops fetalis
viii) Ascites

11 NIPT
5) 10% DNA -
i)
(1) 21 99%
(2) 18 96%
(3) 13 91%
6) Likelihood ration=LR
a) O

 b) Bayes
i) = =LR
(1) =1/11000
(2) = 1100
(3) = 1/11000 1100= 1/10
ii)
(1) = /
(2) = /
c)
i)
(1) <4%
d) ffDNA
i)
ii)
iii) >3
iv) =
v)
e)
i)
(1) >35
(2) Us
(3)
(4) robertsonian
(5) scrreening 1-2ou
ii)
(1) NIPT
iii) 1 screeninh 1
iv)
screening
v) screrening
vi) >1/10
vii)
(1)

(2) 2
viii) /
(1) =
(a) cffDNA
(b)
(2)
(a)

(BPD)

(BPD)

( 23)

90

,
.

.

1) .
,
. ,

( 24).
(BPD) (OFD)
,
( )

2) (HC)
(BPD),
() ()
,
, .
3)
(CI: Cerebral Index) = BPD/OFD 100.
(CI) ,
0,70 0,86 (x100)
0,78 (x100). ( )
> 0,86 (x100),
( ) < 0,70 (x100). ,
,
(BPD) "-", ,
BPD ,
"-"

(HC)

,
( 24).
BPD
(OFD) HC = 1.62 (BPD + OFD).

(AC)

( ).
.
.
 1/3
.

(APAD)
(TAD) : AC = (APAD +
TAD) / 2 = 1.57 (APAD + TAD).

,
2 .

, .


.

IUGR,
. ,
.

,
(AFI), .

Doppler
.
,
.
( 54).
, IUGR ,
(
55).

, [Manning],
0-2, 0-10 :

( ).
( ).
.
.
.

,

 8.

.
,
Doppler ,
.

( 18),
( 11 12)
,
( >7mm,
18 13)( 13 14)



7%.

(HC/AC),
, 1,06-1,25
.

. HC/AC
.
- , (HC/AC > 1,25)

.
- , (HC/AC < 1,06)

.
.
,
(MVP: Maximum Vertical Pocket) ,
2 8 , .
2 ,
8 , .
2) (AFI: Amniotic
Fluid Index),
. (AFI)

( ),

. (AFI) 8-18
, .
7 , 20
, .
3)
(MVP: Maximum
Vertical Pocket) (MVP: Maximum
Orizontal Pocket).
. 15-
50 (cm2),
 . 0-15 (cm2), ,
>50 (cm2), .

emvriomitriki.gr

8 ,
, 1
, ,
.
,
Peter Grannum
1979 (Grannum P. A, Berkowitz R. L, Hobbins
J. C.: The ultrasonic changes in the maturing placenta and their relation to
fetal pulmonic maturity. Am J. Ob / Gyn, 1979: 133: 915-922),
.
0 (Grade 0) : ,
.
.
I (Grade I) : ,

, .
II (Grade II) : ()
,
.

,
.
III (Grade III) : ()
,

().
.

" ".

emvriomitriki.gr