Professional Documents
Culture Documents
Antibitocs
Antibitocs
Aminoglycosides (gentamycin)
Tetracyclines
Macrolides
Chloramphenicol
Clindamycin
Linezolid
Streptogramins
Cephalosporins
(Bactericidal: inhibits bacterial cell wall synthesis via competitive inhibition of the transpeptidase
enzyme)
1st generation Cefazolin Gram-positives
Cephalexin Some gram-negatives
Skin infection
prophylaxis
Same coverage as
cephalosporins +
expanded
Cefepime Pseudomonas
4th generation
coverage + expanded
gram-positive
coverage
Expanded gram-
positive and gram-
Ceftaroline negative coverage,
5th generation
non-suitable coverage
of Pseudomonas
Miscellaneous
Drugs Mechanism of Action Indications and Side Effects
Uncertain mechanism: Part of RIPE therapy
potentially accumulates for TB
in cells dsirupting Can cause
Pyrazinamide
membrane potential and hyperuricemia and
fatty acid synthesis hepatoxicity
Multi-resistant gram-
positives such as
Lipopeptide that disrupts MRSA and VRE
Daptomycin cell membrane Can cause myopathy
(elevated CK and
rhabdomyolysis