us) United States 2) Patent Application Publication co) Pub. No.: US 2007/0048175 Al oy 6) ay @ @) Tichy et al. METHODS AND COMPOSITIONS Fi DECONTAMINATING SURFACES E OR :XPOSED ‘TO CHEMICAL ANDIOR BIOLOGICAL WARFARE COMPOUNDS, aryl J. Tiehy, Orem, UT (U Jarson, Alpine, UT (US) G. Comespondenee Address: US); Brian ‘THORPE NORTH & WESTERN, LLP. 8180 SOUTH 700 AST, SUITE 200, SANDY, DT 84070 (US) Appl. No S10,133 Filed: Aug. 24, 2006 Related Us Application Data Continuation-in-part of application No. filed on Feb. 24, 2006 Continuation-in-part of application No. filed on Feb, 24, 2006 Continuation-in-part of application No filed on Feb. 24, 2006 Continuation-in-part of application No filed on Feb. 24, 2006 11361,836, 112361,837, 11361,841 117361,665, U! SS 200700481751 (43) Pub. Date: Mar. 1, 2007 (60) Provisional aplication No, 60/656,723, fled on Feb. 25, 2008. Provisional application No. 6016S6,723 filed on Feb, 25, 2005, Provisional application No, 601686,723, fled on Feb. 25, 2005, Provisional appli- cation No, 60/656,723, file on Feb, 25, 2005 Publication Classification (1) Insc. AGIL 2/18 (2006.01) (2) USC 42228 on ABSTRACT ‘The present invention is drawn to methods and compositions for use in partially or fully decontaminating surfaces which have boon contaminated with chemical or biological warfare ‘gens. The invention includes contacting the contaminated strlace with a composition capable of ameliorating. the egtive effets cased by the warfare agent, In one embodi- ‘ment, the composition includes an aqueous vehicle of water ‘and. Trom 0.001 wt % {0 40.0 wt % of a peroxygen. Additionally, the composition ean include from 0.001 ppm 4 50,000 ppin by weight ofa transition metal based on the ‘aqueous vehicle content. Optionally, an alcohol can be ‘included in the composition, In one embodiment, the ran- sition metal canbe in the fomn ofa colloidal transition metal, seh as colloidal silver.US 2007/0048175 Al METHODS AND COMPOSITIONS FOR DECONTAMINATING SURFACES EXPOSED TO. (CHEMICAL AND/OR BIOLOGICAL WARFARE, ‘COMPOUNDS, [0001] The present application isa continuation-in-part of US. patent application Ser. Nos. 11/¥61,836, 11/361,841; 11/361,837; and 11/361,668, each of which was fled on Feb, 24, 2006, and each of which claims the benefit of US. Provisional Patent Application No. 6/656,723, fled o 25, 2008, FIELD OF THE INVENTION {0002} The present invention is drawn to methods and ‘compositions for use in decontaminating surfaces contami nated with chemical and/or biological warfare agents, BACKGROUND OF THE INVENTION {0003} Biological and chemical warfare agents are potent Killing tools. Although they were banned by the Biological Weapons Convention of 1972 and the Chemical Weapons ‘Convention of 1998, both chemical and biological weapons remain a legitimate and viable test against people and ‘countries throughout the world. As such, the need exists for ‘an fast and ellective means for deconlaminating surfaces ‘contaminated with biological and/or chemical agents SUMMARY OF THE INVENTION [0004] Ichas been recognized that it would be desirable to provide a method! and an associated decontaminating com Position which would be effective against biological andor ‘chomical warfare agents. In accordance with ths, a method. Tor decontaminating a surface contaminated with 2 chemical ‘oF biological warfare agent ean comprise contacting said furfice with an effective amount of a composition, The ‘composition inclides an aqueous vehicle with water and fiom 0.001 wt 9% to 40.0 wt % of a peroxygen, The ‘composition further includes fom 0.001 ppm to 50.000 pp by weight ofa transition metal or alloy thereof based on the aqueous vehicle content, [0005] Additional features and advantages of the iaven- tion will be apparent from the detailed description that follows, which illustrates, by way of example, features ofthe DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT(S) [0006] Reference will now be made to the exemplary ‘embodiments, and specific language will be used herein t0 ‘describe the same, It will nevertheless be understood that no Timitation of the scope of the invention is thereby intended. Alterations and furher modifications of the inventive fea- tures illustrated herein, and additional applications of the principles of the inventions as illustrated herein, which ‘would occur to one skilled in the relevant art and having. possession of this disclosure, are tobe considered within the cope of the invention. Its also to be understood that the terminology used herein is used for the purpose of deserib- ing particular embodiments only. The terms are n0t intended to be limiting unless specified as such [0007] It must be noted that, as used in this specification ‘and the appended claims, the singular forms “a.™an,” and, “the” include plural referents unlese the content clearly dictates otherwise Mar. 1, 2007 [0008] The term “decontaminate” does not require that complete decontamination occur. In other words, partial decontamination to complete decontamination ar included Whenever the term "deconiaminate,™Jecontaninating, “decontamination,” ee. is used. Further, the use ofthe term disinfect.“ disinfoting, disinfection,” or the like, is used ‘0 include not only fighting infection of virus, bacteria, or other living organisms that may be used for biological ‘warfare, but also includes decontamination of surfaces that fare exposed to harmful chemicals often used in chemical ‘warfare, such as by oxidation of the chemical. Aga complete disinfection i not required for disinfection to ‘occur: Generally, though sanitizers, strilants and disinfec- tants are used for the same purpose, ie. 1 Kill bacteria andr vinses, et, sterilant composition exhibits a greater all evel compared to a disinfectant, which in tur has better Kill level than a sanitizer. This being stated, most applications require only sanitizer or disinfectant levels bacteria/vrus reduction, though otber applications benefit considerably from the use of steriants. Fore the present application the term “disinfectant” is used gen- enlly to reer to each of sanitizers, disinfectants, and ster ilants unless the context clearly dictates otherwise, [0009] The term “solution” is also used throughout the specification to describe the liquid compositions of the present invention. However, as these “solutions” include colloidal transition metals, these compositions ean also be Ueseribed as dispersions or suspensions. As the continuous phase is typically a solution, and the transition metal is present as a colloid, for convenience, these composit ‘ill typically be refered to as “solutions” herein [0010] The term “substantially free” when used with epard 1o the compositions ofthe present invention refers to the total absence of or near foal absence of a specific ‘compound or composition. For example, when s compos tion is sid to be substantially free of aldehydes, there are either no aldehydes in the composition or only trace amounts of aldehydes in the composition. 0011] The term “peoxygen” refer: 10 any compound containing a dioxygen (OO) bond. Dioxygen bands, par ticularly bwalent OO bonds, are readily cleavable thereby allowing compounds containing them {0 act as powerful ‘oxidizers, Non-limiting examples of elses of peroxygen compounds include peracid, peracid sls, and peroxides, suc as hydrogen peroxide. [0012] ‘The tem “biological warfare agent” and “hiologi- «al weapon” are interchangeable and refer fo any biological ‘onganim or toxin that are often used as a weapon of war oF {errorism to kill, injre, or incapacitate. Similarly, she terms “chemical warfare agent” or “chemical weapos refers to chemical agents which have toxic properties and ean be used in war of temorism to kil, injure, or incapacitate. [0013] Concentrations, dimensions, amounts, and other seal data may be presented herein in a range format Is tobe understood that such range format is used merely or convenience and brevity and should be interpreted flexibly to inelude not only the numerical values explicitly recited as the limits ofthe range, but also to ince all the individual numeri values or sub-ranges encompassed ‘within that range as if each merical Value and sub-range is explicitly recited, For example, 2 weight ratio minge of about 1 wt % to about 20 wt % should be interpreted toUS 2007/0048175 Al Include not only the explicitly recited Iimits of 1 wt 9% and out 20 wt %, but also to include individual weights suck ‘as 2.90%, 11 w1%, 14 WU %, and sub-ranges seh a8 101 % wo 20 wi %, 5 Wi % to 15 WI% ee [0014] In accordance with this, the present invention pro- vides a method for decontaminating surfaces contaminated With biological andor chemical weapons, ‘The method ‘involves contocting the coataminated surface with a com- position comprising an aqueous vehicle, ineluding water and from 0.01 wt % f0 300 wt % of a peroxygen. Addtionaly, trom 0.001 ppm to 30,000 ppm by weight of a transition mital based on the aqueous vehicle content can also be present. [0015] I s noted thatthe lower end of the range of the peroxyigen can be mosified to 0.01 wt %, 048 wt, and 0-1 ‘wt % andor the upper end ofthe range can be modified to 301%, 20 wt % oF 10 6 % in accordance with specific ‘embodiments of the present invention. Further, the concen tration ofthe metal content, ineuing ionic andor colloidal mictal content, can also be modified to 10 ppm by weight at the lower end ofthe range, and/or to 20,000 ppm or 10.000 pm by weight atthe upper end of the range. As these anges ate merely exemplary, one skilled in the art could modify these ranges for a particular application, considering such things as the type of alcohol (polyhydrie, food grade, mixtures, etc.) the type of peroxygen (peroxide, peracid ‘combination of poroxidelperaci, ct.) and the type of metal Gonie, colloidal, alloy, et). For example, in treating @ hhuman for exposure to biological or chemical agents, lover ‘amounts of peracid may be used s0 as tb be within safe parameters, Whereas when decostaminating terra firma, ‘ilies, or equipment, higher concentrations of the peracid may be useable (closer to the 40 wt %). Altemativey. if hydrogen peroxide is use asthe peroxygen compound, thea 1 broader range of the material may be useable fora wider range of applications [W016] The aqueous vehicle can optionally ince other ingredients, sich as organic co-solvents. In particular, co im alcohols ca be present Is noted that i a alcohol is present it ean be present at from 0.08 wr % 10 40 WU, the lower end othe range ofthe alcool being mod 10.0008 wt 8% oF 0.1 wt 8% and the upper end of the range being modifiable to 20, 9% oF 10 Wr 6 In selecting he ype ‘of aleool that an be used for example, leas ineading ‘lnhatc sleohols and other carbon-cotsining alee having fom Ito 24 carbons (C,-C alcoho) can be waed eis to be noted tht "C,-C,), alcohol” does ast necessarily imply only straight chain saturated aliphatic alcohols, as ‘olhcr carbon containing aleobals can also be used Within this definition inching rancho aliphatic alcohols alicy- lie aleahos, aromatic alcohols, unsaturated aleobls, as ‘vel as subsite alpha ley, aromatic, and wns Ute sleaols, ete. In one embeadiment, the aliphtie aco: hols ean be Cyto, sleobols including methaool ethane, propanol and isopropanol, butanols, and pentanol, doe to their availabilty and lower boiling points. This being stated, polyydee alcohols can also be used ellectivly in enhanc: ing thedisinfctant and sterilnt potency of the compositions ‘of the present invention, as wel as provide some degree of skied sailiztion. Examples of poly sleohols which fem be wsed inthe present invention iaclude BUL are not Timited to ethylene give (cthane-I.2ol) glycerin (or ulyoerl, propane-1234riol), and propane1 20). Other Mar. 1, 2007 on-aliphatic alcohols may also be used including but not Timid to phenols and substituted phenols, erucylaleobel, ricinolyl alcohol, arachidyl alcohol, capryl aloo, eapric alcohol, bebensl alcobol, lauryl alcoho! (1-dodeeano) ‘myrsiylaleobol (J-teiradecano), cetyl (or palityl) aleohol (F-hoxadecano),steayl alcohol (I-oetadecanol),isosteary! Alcohol, oleyl alcohol (cs-9-oetadecen-I-o), palmitoteyl aleolol, linoleyl alcohol (92, 12Z-octadecadien-I-ol), clay! sleoho! (E-octadecen-|-o),eladotinoley! alcohol (OE, 12E-vctadecatien-1-0), linolenyl aleobol (9Z, 122, 15Z-octadecatrien-10l), elaidolinolenyl alechol (9E, 12E, 15-E-octadecatrien-I-o)), combinations thereof and the Tike [0017] In some embodiments, for practical considerations, vethanol, ethanol, and denatured aleolols (mixtures of cthuol and smaller amounts of methanol, and optionally, ‘minute amounts of henzene, Ketones, acetates, ete.) can often be prefered for use because of their avilability and cost, Glycerol is also preferable for use in some embodi- sens, Ifthe desire is 19 provide a food grade composition as may be desirable for mucosal, ski, of alimentary canal ‘application, thea alcohols ean be selected that satisfy this requirement, AS these ranges are merely exemplary, one stilled in the art could modify these ranges for a particular application, considering such things as whether alcohol selected for use is polyhydric, whether the aleohol is food rade, mixtures of aleohols, ete [0018] | Reyarding the tansition metal, in accordance with the embodiments ofthe present invention the metal can be inn form (¢ a metal salt) andor colloidal form. Inone specific embodiment, the transition metal can be in a sub- meron form (Le. dispersion of less than I wm metal colloidal panicles). However, larger colloidal transition metal par- ticles can also be used in contin applications, Typical transition mals that are desirable for we inchude Group VI to Group XI transition metas, and! more preferably, can include Group X to Group XI transition metals. Alloys ‘including atleast one metal from the Group VI to Group XT metals can also be used. Its recognized that any of these metals will ypiclly be oxidized othe corresponding cation in the presence of pemxyzen, However, with colloidal metal, typically, the surface is usually more susceptible 10 such oxidation. Further, when colloidal metals are dispersed {na colloidal solution, there is often an amount of the metal in ionie or salt fonn that is also present in the suspension solution. For example, colloidal silver may inchude a certain percentage of a silver salt or ionic silver in solution, eg. 10% t0 99% by wight of meta content can be ionic based fon the total metal content, This being slated, certain pre- {erred metals for se in accordance with embodiments ofthe present invention are ruthenium, rhodium, osmium, iridium. palladium, platinam, copper, god, silver, alloys thereof, and ‘xturesthereo?. Silvers offen the most preferred, depend ‘ng on the application, the levels of kill that are desired oF required, the type of pathogen being tameted, the subsirate that is being cleaned, ete. Any of these embodiments ean also benefit from the use of alloys. For Example, certain ‘combinations of metals in an alloy may provide an accep able Kill Tevel for a specific pathogen, and also provide ‘benefits that are rolated more to secondary consideration, such as solution stability, substrate to be cleaned, et Preferred examples of transition metal alloys for use in the present invention include but are not limite to coppersilver