Hasil uji optimasi Bahan Tambahan Tablet

FI F II F III
Ekstrak mengkudu (mg) 500 500 500
[A] Avicel pH 101 (mg) 250 0 125
[B] Aerosil (mg) 0 250 125
P
0,4 kekerasan (kg) 8 4 7
0,3 Kerapuhan (%) 0.7 0.9 0.5
0,3 Waktu hancur (menit) 7 8 9

KEKERASAN
Y = a [ A] + b [ B ] + ab [A] [ B]

Formula I
Y = a[A] + b[B] + ab[A][B]
8 = a 1 b 0 ab 0
8 = a
a = 8

Formula II
Y = a[A] + b[B] + ab[A][B]
4 = a 0 b 1 ab 0
4 = b
b = 4

Formula III
Y = a[A] + b[B] + ab[A][B]
7 = 8 0.5 4 0.5 ab 0.25
7 = 4 2 ab 0.25
7 = 6 ab 0.25
ab = 4

RUMUS PERSAMAAN HASIL OPTIMASI

Y = 8 [A] + 4 [B] + 4 [A][B]

Y = 8 [A] 4 [B] 4 [A][B]

8 = 8 1 4 0 4 0
7.96 = 8 0.9 4 0.1 4 0.09
7.84 = 8 0.8 4 0.2 4 0.16
7.64 = 8 0.7 4 0.3 4 0.21
7.36 = 8 0.6 4 0.4 4 0.24
7 = 8 0.5 4 0.5 4 0.25
6.56 = 8 0.4 4 0.6 4 0.24
6.04 = 8 0.3 4 0.7 4 0.21
5.44 = 8 0.2 4 0.8 4 0.16
4.76 = 8 0.1 4 0.9 4 0.09
4 = 8 0 4 1 4 0
KERAPUHAN
Y = a [ A] + b [ B ] + ab [A] [ B]

Formula I
Y = a[A] + b[B] + ab[A][B]
0.7 = a 1 b 0 ab 0
0.7 = a
a = 0.7

Formula II
Y = a[A] + b[B] + ab[A][B]
0.9 = a 0 b 1 ab 0
0.9 = b
b = 0.9

Formula III
Y = a[A] + b[B] + ab[A][B]
0.5 = 0.7 0.5 0.9 0.5 ab 0.25
0.5 = 0.35 0.45 ab 0.25
0.5 = 0.8 ab 0.25
ab = -1.2

RUMUS PERSAMAAN HASIL OPTIMASI

Y = 0.7 [A] + 0.9 [B] - 1.2 [A][B]

Y = 0.7 [A] 0.9 [B] -1.2 [A][B]

0.7 = 0.7 1 0.9 0 -1.2 0
0.612 = 0.7 0.9 0.9 0.1 -1.2 0.09
0.548 = 0.7 0.8 0.9 0.2 -1.2 0.16
0.508 = 0.7 0.7 0.9 0.3 -1.2 0.21
0.492 = 0.7 0.6 0.9 0.4 -1.2 0.24
0.5 = 0.7 0.5 0.9 0.5 -1.2 0.25
0.532 = 0.7 0.4 0.9 0.6 -1.2 0.24
0.588 = 0.7 0.3 0.9 0.7 -1.2 0.21
0.668 = 0.7 0.2 0.9 0.8 -1.2 0.16
0.772 = 0.7 0.1 0.9 0.9 -1.2 0.09
0.9 = 0.7 0 0.9 1 -1.2 0
Waktu Hancur
Y = a [ A] + b [ B ] + ab [A] [ B]

Formula I
Y = a[A] + b[B] + ab[A][B]
7 = a 1 b 0 ab 0
7 = a
a = 7

Formula II
Y = a[A] + b[B] + ab[A][B]
8 = a 0 b 1 ab 0
8 = b
b = 8

Formula III
Y = a[A] + b[B] + ab[A][B]
9 = 7 0.5 8 0.5 ab 0.25
9 = 3.5 4 ab 0.25
9 = 7.5 ab 0.25
ab = 6

RUMUS PERSAMAAN HASIL OPTIMASI

Y = 7 [A] + 8 [B] + 6 [A][B]

Y = 7 [A] 8 [B] 6 [A][B]

7 = 7 1 8 0 6 0
7.64 = 7 0.9 8 0.1 6 0.09
8.16 = 7 0.8 8 0.2 6 0.16
8.56 = 7 0.7 8 0.3 6 0.21
8.84 = 7 0.6 8 0.4 6 0.24
9 = 7 0.5 8 0.5 6 0.25
9.04 = 7 0.4 8 0.6 6 0.24
8.96 = 7 0.3 8 0.7 6 0.21
8.76 = 7 0.2 8 0.8 6 0.16
8.44 = 7 0.1 8 0.9 6 0.09
8 = 7 0 8 1 6 0
 MENGHITUNG PEMBOBOTAN (R TOTAL)

R 1 KEKERASAN R 2 KERAPUHAN
Formula [A] Avicel pH 101 [B] Aerosil
Y N N*P Y N N*P
A 1 0 8 1 0.4 0.7 0.333333 0.1
B 0.9 0.1 7.96 0.99 0.396 0.612 0.626667 0.188
C 0.8 0.2 7.84 0.96 0.384 0.548 0.84 0.252
D 0.7 0.3 7.64 0.91 0.364 0.508 0.973333 0.292
E 0.6 0.4 7.36 0.84 0.336 0.492 1.026667 0.308
F 0.5 0.5 7 0.75 0.3 0.5 1 0.3
G 0.4 0.6 6.56 0.64 0.256 0.532 0.893333 0.268
H 0.3 0.7 6.04 0.51 0.204 0.588 0.706667 0.212
I 0.2 0.8 5.44 0.36 0.144 0.668 0.44 0.132
J 0.1 0.9 4.76 0.19 0.076 0.772 0.093333 0.028
K 0 1 4 0 0 0.9 -0.33333 -0.1

Harga Normalisasi
N = (X - Xmin)/ (X max - X min)
Pembobotan
Syarat kekerasan = 4-8 0.4
Syarat kerapuhan = max 0.8% -0,1% (0.5 - 0.8) 0.3
Syarat waktu hancur = kurang dari 5 menit - 15 menit 0.3
 R 3 WAKTU HANCUR
R Total
Y N N*P
7 0.777778 0.233333 0.733333
7.64 0.706667 0.212 0.796
8.16 0.648889 0.194667 0.830667
8.56 0.604444 0.181333 0.837333
8.84 0.573333 0.172 0.816
9 0.555556 0.166667 0.766667
9.04 0.551111 0.165333 0.689333
8.96 0.56 0.168 0.584
8.76 0.582222 0.174667 0.450667
8.44 0.617778 0.185333 0.289333
8 0.666667 0.2 0.1