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Paracetamol Granule Preparation Methods

This experiment aims to prepare 50g of paracetamol granules using dry and wet granulation methods. The formula includes paracetamol, diluents like starch, and binders. For wet granulation, a binder solution is added to the mixture and granules are formed, then dried in an oven. For dry granulation, a starch binder is added and granules are formed. Both methods successfully produced paracetamol granules.

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Nur Nabilah
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235 views1 page

Paracetamol Granule Preparation Methods

This experiment aims to prepare 50g of paracetamol granules using dry and wet granulation methods. The formula includes paracetamol, diluents like starch, and binders. For wet granulation, a binder solution is added to the mixture and granules are formed, then dried in an oven. For dry granulation, a starch binder is added and granules are formed. Both methods successfully produced paracetamol granules.

Uploaded by

Nur Nabilah
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Experiment 2

Aim

To prepare 50g of Paracetamol granules using dry and wet granulation method.

Formula

Paracetamol 100mg

Diluents 50g

Binders (starch) 5%

Procedure

1. Paracetamol powder, diluents and binders are weighed and prepared accordingly.
2. In a mortar, paracetamol powder and diluents is mix homogenously.
3. Then, in case of wet granulation, binder solution is added into the mixture little by
little and mix gently using pestle (no pressure is applied). For dry granulation, the
starch powder is added into the mixture and mixed gently.
4. After granulation is formed, the granules are sieves in order to collect the granules.
5. For wet granulation, the granules are dried in a hot air oven after sieving is done.

Results

Conclusion

1. The granules are successfully prepared using both dry and wet granulation.

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