Agents

Used in Hyperlipidemia

Yamil Gerena, Ph.D.

Principles of Pharmacology:
The Pathophysiologic Basis of Drug Therapy
David E. Golan

Copyright
Copyright
2017,
2010,
YGL
YGL
Structure of Lipoprotein Particles
Editing of apoB mRNA
Assembly and Secretion of Apolipoprotein B-
Containing Lipoproteins

microsomal triglyceride-transfer protein (MTP)

Absorption of Cholesterol and Triglycerides
Intravascular Metabolism of
apoB-Containing Lipoproteins
Formation and Hepatic Uptake
of Remnant Particles

LDL-receptor-related protein (LRP),

Formation and Clearance of LDL Particles

acetyl-CoA:cholesterol acyltransferase (ACAT)

LDL and Atherosclerosis
Reverse Cholesterol Transport

ATP binding cassette protein AI (ABCA1)

lecithin:cholesterol acyltransferase (LCAT)
phospholipid transfer protein (PLTP)
Cholesteryl ester transfer protein (CETP)
scavenger receptor, class B type I (SR-BI)
Biliary Lipid Secretion
 Lipoprotein disorders
Detected by measuring the content of lipids in
serum after a 10-hour fast

National Cholesterol Education Program:

Adult Treatment Guidelines
Total Cholesterol LDL Cholesterol
(mg/dL) (mg/dL)
Desirable <200 <130
Borderline to high 200-239 130-159
High >=240 >=160
The primary hyperlipoproteinemias and their
drug treatment
Mechanism of LDL Lowering by Statins

sterol regulatory element binding protein (SREBP)

Influence of Fibrates on Lipid Metabolism
Influence of Niacin on Lipid Metabolism