Gawk Yea B phen Sm- OE. QP Code: 7808 (3 teers 1} Feat Marta 78 (2) A pueamone 9 eompsnieney 2) Fogurne ns tha eng dicts Bot mare 119g te prong of Lee teeing s 13) LAL naming tt ser ht ating a8 Beveotom of syeme sete thee tirmlaiin whbiinan pasbging Smear Hemme os ¢ tate prevervations ane ss apni gronbucne jl wane te crane ot paca of premereeion oMRewe we 10) Compare and sonrenes enue wnt sani srhenns tov Sasirery co 4) Sow ts tnd ts eee gS, yeoman nwane agysation 26 Acshoniing Sein ot smniianing we prenncnnete geibaens Commarant on nbiiones uma? he Karmann 92 wn enna parentarnoh (ivan shoe sunt ne ine her Erenaae otakacras dngeetaciom vt gM settee wid ems Ma meds nuns mah degra oa Doma ea Aeration bony nd ogres werent ei aioe sues heme ss oom ae aesa verre om, 3 os a iguaity ponceed tara Boma am rater Cheoee Daecwen in detail propa cf diay © oa conaadenet a Gege 2 SH evens s €) Waite enit oe YOK abtatines fr acetone sunny satien 1TURN OVERBral Yeay Beprerm Sem ~ Yr QP Code: (3 Hours) NBs (1) All questions are compulsory. (2) Figures to the right indicate full marks. State the principle of Leaker testing (i) LAL teatingis better than rabbit esting in detection of pygens. Justify. we Discuss formulation additives and packaging in ophthalmic ointments. e cote ¢ Eli preservatives uted in ophthalmic products gi stat the eters of passing of preservative efficacy test. ev {i Compare and conrest sustained and cop Sed release drug dtivery system, s (i) How isthe toil dose eatelated ig. systems Diseuss application of Arteniugatision in prediting she iife of pharmacentical products, gS ‘Comment on additves usegiga the formulation of small volume parenterals. Waite a short note on ogr bioavailability. Discuss oxidative degRatonin pharmaceuticals and state the methods to minimize such degFadations. a on Describe thé iyarolytic degradation pathway and approches to prevent it 8) _Elabgfite on the glass containers in pareneterals and discuss tests to ‘igtiguish between them. S on $Y Enumerate the quality control tesis done on rubber closures. » GS Discussin detail properties of drugto ve considered in design of SRsystem. gr Wein deta on 1H gudetnes for coserted stability studies, [TURN OVER LO-Con. 7008-15.a) ») °) a) ») a) b) ce) eae Elaborate principle and steps in Freeze drying of sterile ‘Write quality control testing of ophthalmic suspensions.” Discuss dissolution based controlled dus delivery system. oR products. Differentiate between matrix and reservcir base: system. = . & ‘Discuss the formulation of large volume parenterals. ve 4 Elaborate on evaluation of ‘oral controlle4 drug, delivery Sistem. Discuss the form fill seal technology ia parenterals, 4 C ae Discuss the HEPA filter and laminar air flow. fiw go you monitor the 4 environment in aseptic area. = Give the iayout for parenteral manufactus}ig facility. 3 ion 4 State the types of lenses and elaborctevan contact lens so s)“ pram Aral sis Con. 5748-12. (REVISED COURSE) CN-6577 (2 Hours) [Total Marks : 40 (1) Question No. 4 is compulsory (2) Attempt any four questions fom the remaining questions, {@) Answer all subquestions together. 1 2 “ Figures to the right indicate full marks. {@) Draw neat and labelled diagroms wherever necessary (6) Use of calculator is allowed. ° ® @ ) 3 (@) 4 5. » 10) () ©) ) Expiain the fotowing ters (any three) = () Eddy difusion {i) Gel permeation chromatography Precision (jv) Gradient elution. ‘Name the following (any two) = {)_ Technique in gas chromatography used for determination of residual solvents Gi) One detector in HPLC where simutaneous determination of ‘components, at different wavelengths, can be made. {Gy Two visuatsation techniques in TLC. What are the advantages and disadvantages of gas chromatography Ot HPLC? Deseribe in briet Deset® pormal analysis” Describe the technique of diferent seanning ‘calorimetry in detail Describe the instrumentation of HPTLC. Deseo fanaa mato wporart 7 ve memporance of etaiaien, lof Limit of Detection and Limit of Quantification. piatinguish between lon Pair and fon Exchange Chromatography Deserbe the various sampling techniques for quis. Describe the various quantification techniques used in HPLC . eer matogram of a mixture And B provided the following data on 2 25em column. Retention time (mnin)] Width of peak base (W). ‘min [Non retained 34 = A 54, ost 3 193 107 Calculate () Number of theoretical plates for A {i)_ Resolution between species Aand B. [TURN OVERone Srag-cn-6577-412- 2 6. (@) with respect to chromatography expla the following terms (i) Capacity factor (ii) Selectivity factor (i) Relative retention time {u) Reverse phase chromatography. .d for the analysis of five different iron (0) Two different methods A and B, were uset Tematations, The percentage ion content in each of five samples is tabulated for methods A and B. Sample 1 2] 3 ra Method A| 17-6 68 | 142| 205 97 Montod B| 179 | 71 | 138| 203] 102 Use paired ‘t test to see whether results: ‘of Method A and Method Bare same or different at 95% confidence interval [tabulated 't value is 2:78 at (p = 0-05)] Write short notes on any two: {@) Developmental techniques in paper chromatography (0) Columns used in gas chromatography (¢) Differential Thermal Analysis (@) Linear Regression Analysis. 7 4 VAY y iy: ve AY cy& & Q22 \ a mio var I1Zy05/} Sem-WIEC CATRT i Sub- Pharm, Anal¥sis QP Code : 24965 5 (3 HouRs) (TOTAL MaRKs-70) Ss All questions are compulsory. Answer all syb questions together. Draw neat labelled diagrams where necessary, Figures to the right Indicate full marks. Doas directed (apy sevon): , ive eny 2 factors affecting resolution in TLC. Give the splitiing pattern of CH In CHe-cHICh ‘CHOW ‘Give two point *+ of differentiation betwee UPLC and HPLC. .¢ Name the peak with highést m/z value ina mass spectrurfh Baar \fcompourd Ais note polar than compound B, whic mpound will be ° heed fst RP-HPLC? 9 On ttm two tow of columns used i axe chron aeraphy, Namie two interfaces used in GOMS. «/~.\ Name a gas chromato, solvents Explain the term (any four): Gradient elition, AS ep Spin lattice relaxation, Herp a 3) 3 Precision studies i@Validation of analytical procedures, mar |S me & RS) ‘Answer following (any two): P ) PisqusSany2 type of pup usedin upc, 7" {Ue * note oh lon-palr chromatography, in. 0 ve the significance of fechnique. Dis. ig tne HeDifcance of LO-MS technique, oi USE ony 1 Interface used In Lé- TURN OVERc @P Code : 24965 : 2 be Reompound P was analysed on two eiferent columns OF HPLC. The following (3) dota was obtalned: he retention time of P when anslysed on 2 25 nin ond width of the peak at base was 0.52 min retention time was 7.35 min an‘ im length of column was 22.42 When P was analysed on 3 10 d width of the peak at G a > 032 following (any two): @) oe ihe ling compounds the se of sftatlespsioscone 9 ceohnigue Justify your answer glving is spectral characteristics. ae Cyenort ond ZS -0- cnc Hg wo f. Explain spin-spin splitting In H-NMR spectrpfBSpy with the help o: example. ~ Been < en asim ov any 2erenaton pay (ih floningoreint| x“ " Cen ets xx bravia diagram depictingsteps of two dimensional TLC. e g a 0.83, Answer the folleing (omy t0) yi ER! (8) 1 Bella apf ogee camber vila Moserpecvometer, ee W” Biscuss Gi ostors that affect chemical shift value in NMIR spectroscopy. TURN OVERrem wince F Binal Yenr 8. pharm V em & aa QP Code : 21799 (3 Hours) (TOTAL MaRKs-70) Ne: F a 1. All questions are compulsory, rx 2. Answer all sub questions together, Ny 3. Draw neat labe! 4 diagrams where necessary a ‘4% Figures to the right indicate full marks 1.2. Doas directed (any seven): ;_Reme Any two visualisation techniques used in TLC Te Nay cc) sv any bv solvents usedin kt specrosapy f_ Gee mlemeleserion peak forcortentee, CS wy Fea ie onion technigues used inmase Shcvometn, 8 “Nome stationaiy phase used in roverse Phase HPL. < ent ured ih Paver chromatography, Wh” Gvean example ofa buik propery detector used in HPLC. vil. Name an’nteral stand used in Mt spectroseomy Explain the term (any four): (5) bTailing factor in uve. i, Two dimensional Tie. fie Tne, : Bese peak in Macy spectrutm, 2 %couping confine (3) Discuss any 2 interface used in Lc.ms, TURN oveR LO-Con. 5934-15,ap Code : 21799 \ 2 \ sere separated on 2 15 em HPLC column. The retention (3) $152 min and 10.14 min respectively. The peak widths ‘051 min and 0.94 min respectively. ‘compounds X and ¥ times of Xand Y were atthe base for Xand ¥ were Calculate: i. Humber of theoretical plates for X Ti. Resolution between X and ¥. ¢ asa Answerthe following (any two): fe Distinguish the folowing compounds by the use ofa suitable spectroscost! technique. Justify your answer giving its spectral characteristics. 2 CHy-CHz-CH;-O-CHy "and CHy-CHy-CHy-CHyO-CHy-CHy 1. Bolin soin-spinspliting in H-AMAR speevroscopy. : J Go iti Depict any.2 fragmentation pathways for the following tompound: eg} CHa — CHa 0 3 Give any 3 factors effecting resolutich in TL. @) | Qa. Answer the following (anys): () | i Draw a block diagram shWing varlous components of a mass spectrometer. Mame any two analysets“used. ii, seuss any 2 factors affecting chemical shift value in 1H-NMR spectroscopy. Go 1H, With retereneto analytic method validation, explain the conduct of Precision ses, e ». Give glchematic classification of chromatographic mathods ei TURN OVER,Is PINZOIe di Semin Cea sost mee Subs — pharmaceloey Ie W e- QP Code : 500802 G Hours) [Total Marks : 70 N.B.: (1) All questions are compulsory. (2) Figures to the right indicate full marks. (a) Answer the following :~ 12 (i) Classify antipsychotics. (ii) Give role of misoprostol in management of peptic ulcer. 66 (iii) Justify use of antimicrobials in treatment of diarrhoea, (iv) Describe the triple action of histamine. (¥) Explain mechanism of action of phenytoin. (vi) Why are non-steriodal anti-inflammatory drugs contraindicated in the third trimester of pregnancy. (b) Answer the following ~ 3 (i) Name any two therapeutic uses of serotonergic. drugs. \ 9 (ii) Enlist contraindications for use of emetics. iii), ——— is an example of an atypical anti-psychotic agent. (a) Answer (any two) of the following -— 8 > (Describe the stages of general anaesthesia (ii) Describe the pharmacological actions of ethanol, (iii) Describe pharmacotherapy of Parkinson's disease. (b) Write short note on any one of tie following :~ 3 @_Valproic acid Gi) Diazepam (@ Answer (any two) of the following (i) Classify non-steroidal anti-inflammatory drugs. Describe the general: adverse effects and uses of NSAIDs. (ii) Give Tole of corticosteroids and leukotrine antagonists in ae management of asthma, ii)“ Comment on use of xanthine oxidase inhibitors in ph: = cothereapy of gout. (b) Ansiver (any one) of the following :~ -S" @ Describe the biosynthesis and role of bradykinin, Gi) Write a note on therapeutic uses of antihistaminics iarma- (TURN OVERQP Code : 500802 (a) Write short notes on any two of the following > (i) Pharmacotherapy of inflammatory bowel disease. a (ii) Prokinetic agents q 2 (iii) Antacids (b) Answer (any one) of the following = (i) Compare H blockers with proton pump inhibitors I (ii) Write a note on irritant purgatives. gyre 4. 5. (a) Answer (any two) of the following :~ 8 (i) Deseribe pharmacology of chlorpromazine. + Gi) Discuss management of Alzheimer’s disease. (iii) Describe mechanism of action of local anaestl: Why are amides preferred over es (b) Write short note on any one of the following (i) MAO inhibitors ' (ii) Preanaesthetic agents. ie agents a 3 6. (a) Deseribe symptoms and management of any two of the following = 8 (ii) Mercury toxicity short note on any one of the following 3 (i) Biosynthesis of cicosanoids [| Oo: (ii) Ergotamine. DY/2 ) WiSub- Forensic Phanv7 voy Q.P. Code :01438 [Time: 3 Hours} [ Marks:70] Please check whether you have got the right question paper. 1. All questions are compulsory 2. Figures to the right indicate full marks. 5 Q.1A Define any five: i, ‘Repatriate’ as per Pharmacy act ji, ‘New drug’ as per D & Cact. ‘advertisement’ as per DMR (OA) act. ‘Manufactured drugs’ as per NDPS act ,. ‘Formulation’ as per DPCO vi. ‘Contaminant’ as per food safely and standards act. B Define ‘Medicinal preparations’, ‘Alcohol’ and ‘Restricted preparation’ as per MTP(ED) act. Distinguish between 5 ‘manufacture in bond and manufacture outside bond €. 1. Whatdoyoumean by bal? What do you understand by bllable offences? 3 il Elaborate on Narcotie Drugs and Psychotropic Substances consultative committee 2 0.2 Biplane process and caleulation of fxation of cling price of scheduled formulations 4 B Define Patent’ as per Indian Patent act. Elaborate on process of grant of patent in Indi 4 Enilst duties of government analyst. 3 oR Wite note on export under bond. 3 13 A Enlst the various offences and penalties under NOPS act. a B Write a note on labeling and packaging of cosmetics. 4 € Describe role of'30 3 oR c)_Ss 1 (@) Loratidine (b) Nizatiine " (Gi) Name the drug that inhibits the enzyme Na-K*ATP ase in cardiac cells, 1 (4p Classify the following local anesthetics crue to chemical lasses )Benzocaine b) Bupivacaine ©)Diclonine )Eugenol (a) Lstthe N-musturd drugs that functions alkylating agents, Deseibe their mechanism ofaction 4 andSAR () Outline the synthesis of Worfarin indicating the reagents and reaction conditions. . (©) Listthe therapeutic targets exploited in the treatment of HIV infection. Give the structures and ‘mechanism of action of drugs acting upon any two targets 3. (@) WhatisHMG-Co Reductase? Describe the development of HMG-CoA reductase inhibitors. 4 (©) Outline the synthesis of Procainamide indicating the reagents and reaction conditions. (©) Givete advantage ofsecond generation H, antagonists. With respect to loratdine and cetirizine explain the structural modifacations that resulted in decreased CNS side-effects. rr TURN OVER 1 Bin. aameu ety Ser VIT CATKT) Sub-— Pharm. Chem. IT QP. Code :02267 G-ae) (rime: Three Hours News {ars:70) Please check whether ou Ns: 1 Al Guests ae ompuliony Neh aveston paper ‘Answer the following questions. i. Identify the structure given below, indicate its use and mechanism of act ke WS I OH NH: on Ji, Give the name of a non-nucleoside revers 1. Give the name of anon nucleoside reverse transits inhibitor. cS Give an example af card hoi rg andndae suse ee iv. Give the structure of a nitrite containing cardiovascular drug, Cs v. Identify the following structure and indicate its salt form. cert vi. Give an example of a potassium sparing diuretic along with its structure. oa i, What is aliskiren? Indicate its use. 8 vil Give the structure and biological zctivty of 3,5-dimethyl 2,6-dimethy|-4-(2-nitrophenyl)-.4- dihydropyridine-3,5-dicarborylate. on ix. Give an example with structure of an anticoagulant drug. on X Give the ctrusture and mechanism of action of 5-(2-dimethyiahenoxy)-2,2-dimethyl-pentanoic acid. Ot i. Give an example of a drug belonging to Hs receptor antagonist class and indicate its use on 02 xi Indicate the chemical cass of mepivacaine and ts use. wii Give the structure of a thiazofidinedione and name two drugs in this class and indiate thei use, 2h Give the structure ofthe following drugs, clasify them into appropriate mechanistic class and discuss 04 their mechanism of action: oxaliplatin, 6-thioguanine, procarbazine and S-fluorouracll Raaeee nag -COA reductase inhibitors in detail and support your answer with relevant structure, MS Catch the following and support your answer with sultable structures ofthe ruts 3 S.no. Drug 1WPAC name 1 Tolbutamide ree tal Hydroxy-3(propylaminolpropenyleheny-aphynyipropen-1- ' b. Adamantan-L-amine \ Furosemide 4 Propafenone A: With respect tothe strvetre given below, answer the following dbestion. ; 7AOBGASSDD23014BCFEOB70C3DBOICES Fa.P. Code :02267 ing to this class of compounds. 2. Identify this structure and name two drugs belonei : cat the at : J ring and indicate their impact on activity b. Indicate the nature of substituents on the 4-pheny/ Ester substitute at C-3 & 5 positions are identical. say true or false. Justify 4. indicate the effect on activity ifthe heterocyclic ring is oxidized. 8. Give the synthesis of glyburide ingicating the reagents and reaction conditions used. 03, C. With respect to antihistaminics, discuss the SAR of H; receptor antagonists and indicate the 04 ‘advantages of the second generation H11 antagonists over the first generation drugs. Support your ‘answer with suitable structures. 2.4 _A. Classify diuretics giving suitable structures. Discuss the mechanism of action of site 4 diuretics. 04 £B. Give the synthesis of melphalan indicating the reagents and reaction conditions used. 03 C. Give the metabolites of the following drugs. 04 2.Nifedipine c. Minoxidil ¢. Benzocaine b- Propranolol _d. Enalapril QS A Classify local an aesthetics giving sultable examples of drugs along with structures belonging to each 04 class. 03 8. Give the synthesis of saidothymidne indicating the reagents and reaction conditions used 0s €. iscuss in detail fany two) 1 Vasodilators 2. Angiotensin 1 receptor blockers 6A With repectto the following structure, answer the questions given below. on ° ° ul Il fy NH — NH a : ° 4. Wdentify the chemical class ofthe above structure andits therapeutic ure B: Indicate the substitutions at R-positin that wilincrease geting ne etheimpact of having =ethy and-propyon the activin TAOBGAS1DD23014BCFEOB70C3DBOICEDQ.P. Code :02267 4d, Give the number of chiral centres in the above structure B. Indicate to which mechanistic class do the following drugs belong. Structure to be given (any 3) 03 2. Sotalol b. Quinidine «. Tocainide 4. Verapamil . Answer the following questions (any 2) 04 2. Aspirin is used as an antiplatelet agent say T/F . Justify b. Minoxidil is a caleium channel blocker. Say T/F. Justify . Mannitol is a site-2 diuretic say T/F. Justify. Bg ces ‘TAOB6A84DD230148CFEOB70C3DB01CE9 HhSem Ni) CATKT) es a ty Sub- Pharm. Analy or Q.P. Code :03890 t : Three Hours) Please check whether you have got the right question paper. Ne: All questions are compulsory, Figures to the right indicate full marks. Answer all sub questions together Draw neat labelled diagrams wherever necessary. QA A Doas directed fany 7): 07 i) Name two types of columns used in gas chromatography. Name two solvents used in "H-NMR spectroscopy. iil) If compound Ais less polar than compound 8, which compound will be eluted first in RP HPLC? iv) Name any one ion pairing reagent used in HPLC. v) Name the technique used in analysis of residual solvents, vi) Name one internal standard used in "H-NMR spectroscopy. vil) Give m/z value of base peak in mass spectrum of benzene. vil) Name two solute property detectors in HPLC. QA 8 Explain the terms {any 4): 08 ) FT-NMR ii) MALDI Fb iii) Capacity factor in HPLC & Ww) Coupling constant v) Asymmetry factor. Q.2. A Answer the following {any 2}: 08 1) With the help of suitable diagram, explain construction and working of reciprocating pumps used in HPLC. Write its one disadvantage. ii) Explain the principle involved in separation of ions by ion exchange chromatography. iii) Enlist various interfaces used in LC-MS. Discuss any one in detail. 2B Retention time of a compound when analyzed by HPLC was found to be 15.47 minutes. The peak width at the 03 3 ‘base was 0.75 min. Ifthe length of the column is 30cm, calculate number of theoretical plates and plate height. 3 “A Answer the following (any2}: |). Distinguish the following pair of compounds with the use of suitable spectroscopic technique. Justi your answer giving its spectral characteristics. CHy— CH; — O— Circ And CHi— CH cH — 0 — Cs ‘TURN OVER. ‘A831D34B711A8411AFC72EDDBA3P6S3E 1QP. Code :03890 inways forthe fllowing compound in mass spectrometry any two fragmentation Path ii) Depiet any two ° y —CHy Qe ave omar * sing patter for protons of ethyl methy! Ketone splitting patte ity Expainthe : -opraphic technique in TLC. Give its advantage. > 0 swo dimensional chromatographic t 43. Drawa diagram depicting ny 2) 08 wer the following anv): . 2 A Answer the folowing ant able digram explain working of quadrupole mass analyer. ; 2 erisin any two factors affecting chemical shift in H-NMR spectroscopy. 1 gators parameters fr validation of analytical method as per ICH guidelines Explain determination of any one parameter in detail. {4B Draw the diagram of heodyne injector in ‘LOAD’ and “inject” postion used in HPLC. 0 25 A Answer the following fany2 os 4) Withthe help of suitable diagram explain the working of thermal conductivity detector in Gas Chromatography. ji) Pregict the structure of compound giving following spectral characteristics Molecular formula of the compound is GHsOz absorption : 3500 crn", 2941 em’ ,1213 em ‘H-NMR (ppm) 48 (bs, 2H) 4.05 (tH), s(Hz)=7.2 2.75 (quintet, 2H) , (Hi) Give proper justification for the same. 1) Predict the structure of following compound | ‘Molecular formula CHiN, Spectral characteristic of compound are as follows 'R (cm? )= 2941,2273,1460 TANMR dppm = 2.72 (septet,tH), \(H2) 233 (doublet,6H), —He}=6.7 ‘Give appropriate justification for the same, 15. B Pred A max forte fl a ":Amax fr the folowing compound showing UV absorbance Just your answer. ° ‘TURN OVER ‘A83ID34D711AB4ILAPCT2EDOBASPOS3P ’QP. Code :03890 Q6 A Answer the following (any 2) 1) raw block diagram showing various components of Gas chromatography instrumentation, Explain any two applications of this technique i) Differentiate between The 2. Stationary phase . Visualization techniques, 1H) Discuss simultaneous equation method used in UV spectroscopic analysis ofa multicomponent formulation, 08 ‘and paper chromatography based on 6 B Give I absorption Frequencies forthe fllowing funcional groupe 03 a) O-H stretch of primary aliphatic aeons 8) _N-Hatretch of primary aliphatic mine €)_ C20 stretch of aliphatic ace ‘AB3ID34B711ABAIIAFCT2EDOBAIFGSIF(Mime: 3 Hours) [iMarks:70] Please check whether you ether you have gt the ght question paper NB: 1. All questions are compulsory. es 2. Figures to the right indicate full marks. 2) Answer the following: a (i) State the adverse effects of aspirin onthe stomach and kidneys. (i) Explain the MOA of Sucratate (ii) Uist the adverse effects of atypical antipsychotic agents (iv) - When is ORS therapy incicated? () Classify general anesthetic agents. (i) Compare Cox 1 vs Cox 2 2) Answer the following: ) w is used to treat anxiety. 3 (i) Give the biological actions of platelet activating factor, (i) How does Senna exer a lonatve effec? 2 a). Discuss the pharmacology of any twa the following: 8 (Chlorpromazine (i) Phenytoin (ii) Diazepam 2b} Writeashort note on (any one}: 3 (Selective serotonin reuptake inhibitors (i) Theophytine 3 a} Discuss the pharmacotherapy of any two the following 8 (Asthma (i) > Migraine (ii) Gout Das oy Arewer anyone afin folowing 3 (i) Give the therapeutic indications of NSAIDs. (i) What are the side effects of H receptor blockers? 4. a}: Answer any.two of the folowing: a (i) Discuss the pharmacotherapy of 180. i). Classify the drugs used forthe treatment of constipation. Add a nate on bulk purgatves. (ii)__‘Comment on proton pump inhibitors. Q-4 ~~ b),-Write ashort note on any one ofthe following: 3 ‘ (0, Nonsystemic antacids (i).2_.Antimotilty agents in treatment of diarrhea 1 TURN OVER 8913A8918516488F2A82972FFD332467 eQP. Code :01998 a 5 a) Describe the mechanism of ation and adverse effects of any two: (Ethanol Morphine (ii) Lop 5 by Writeashorenote on fany one): 7 )_Preaneasthetic agents (i) Uthium carbonate 26 a) Answeranytwo ofthe following: 8 )) Give symptoms of opium poisoning. Add a note on is specific antidate. Discuss in bref pharmacotherapy of Alzheimer’s disease (ii) Wiite a note on arsenic poisoning. 26 —_b) Writeastiort noteon (any ons (Selective COX 2 inhibitors (W)—Bradykinin Se y US WY EA y 2 TURN OVER sp 3AB9LESISAEAF2AS2972"7°D32467' ode 2h} 04] \7 Ser. ane Sub- pceakics BE Q;P. Code :01380 [Time: Three Hours} { arks:70) Please check whether you have got the right question paper. NB: 4. Allquestions are compulsory 2. Figures to the right indicate full marks. 2} i) State the principle of leaker test, (02) i State the importance of particulate matter testing areterl Formulation (02) 'b)_ Discuss composition of Ophthalmic suspensions. SEES SESS 08 Se SES OES SSS : ‘ ¥s ) f biscuss packaging and labeling of ophthalmic ointments. / €)biscuss limitations of conventional drug delivery systems and need for sustained release (08) systems. 4) State imitations of Arthenivs equation. (2 (») f li) state the formulae for calculating Half-life and set ife ofa prod a) Discuss various routes of parenteral administration and significance of pyrogens in parenteral (08) formulations: eae Sos b)_ Write thé composition of tear fms ants seiicance. (03) ce) Dicuss xiatve degradation pathway anametiods to prevent (os) H oR Discus photeitc degradation gator an methods t overcome it. alsandmethodstodtingsh (04) 3} Write a nate on glass as packaging material for parenters Between yes of lit &e oR : Discuss {oie fil, Seal technology utlized for packaging of parenteral formulations: Se. cctv we Siocon periesetugtotaconsaeed nonunion fe (oa) © -gystained release systems: studies and importance of ICH guidelines for (03) s snce of accelerated stability conduct ince stability studies. ATEDBFDBSF77D416BBSSOFS3A0EE342BQ.P. Code :01380 a) Wate anote on freeze drying process used in parenteral formulations. b)- Discuss evaluation tests performed on empty collap: €)_Desarbeciffsion controled sustained release SYs}6™S- S gas Ssee4 pescribe matrix type sustained release systems 5. a) Discuss composition of large volume parenterals. 3b) Howvill you evaluate sustained release dosage forms? €)_ Write 2 note on interaction between parenteral formulation and its container. 6 a). Discuss environmental control in parenteral production facility. WSs 5) Write about the precautions taken by personnel working in sterile product mariufacturing at < - «Discs various types of contact lens solutions and ther packaging" (04) sible tubes used for ophthalmic ointments (03) (oa) (04) (03) (04) (04) (0a) > (04)QA Doas directed (any 71: 0 w P wi) Oo 9) y vi) vi) vii) 4B Explain the terms (any a a iy ity ) . w No: pote (3[4[2erb P'Brslisig Sem Vil CATT QP. Code :03890 [Time Three Hours] omarks:70), Please check whether you have got the right question piper. All questions are compulsory. Figures tothe right incicate full marks, Answer all sub questions together Draw neat labelled diagrams wherever necessary o ‘Name two types of columns used in gas chromatography. Name two solvents used in "H-NMR spectioseapy. compound Ais ess polar than compound 8, which compound will be eluted fst in RP HPLC? Name any one ion pairing reagent used in HPLC Name the technique used in analysis of residual solvents Name one internal standard used in H-NRR spectroscopy. {Give m/z value of base peak in mass spectrum of benzene. . Name two solute property detectors In HPLC FTNMR. Matol pacity factor in HPLC Coupling constant ‘Asymmetry factor. .2 A Answer the following fany 2 os iy With the hefp of suitable ciagram, explain construction and working of reciprocating pumps used in HPLC. Write ts one disadvantage, {Explain the principle involved in separation of ions byion exchange chromatography. Enlist various interfaces used in LC-MS. Discuss any ane in detail. a2 B retention tine ofa compound when aay ty HPC wos found 0 be 15.47 minutes Te peakwidthatthe 03 tase was075 mn fae length af the columns 3c, cakulte nambere theoreti lates an plate Pht. Distinguish the following pair of compounds with the use of suitable spectroscope technique, ustify ‘your answer giving is spectral characteristics. | @.3 A Answer the following (anya O a Hy cH; — 0— cH — cH And Oty Gc — 0— cH, TURN OVER = ‘ABSIDMAB711A8H1IAFC72ED00ARF6S3FQ.P. Code :03890 4) Depiet ny two fragmentation pathways far the folowing compound in mass spectrometry ° Ml Qram ara toa lil) Explain the splitting pattern for protons of ethyl methy! Ketone, 1.3.8 Draw diagram depicting two dimensional chromatographic technique in TLC. Give its advantage 03 (44: Anesth flowin Lanz = Fea abe dgram exloin working of uadrpole mat nae. ana natca tacts affecting chews shitin HAMM spectroscopy aaa ee ster frvatdntoncfanltal metre os erie guidelines Exgsn 6 determination of any one parameter in detail 4 B Draw the diagram of rheodyne injector in ‘LOAD’ and “Inject” position used in HPLC. 03 5 A Answer the following {any 2): 08 ') With the help of suitable diagram explain the working of thermal conductivity detector in Gas Chromatography. ee ee ee ee i eae cea absorption ; 3500 cr 294% cm, 1213 cm c f san opm 5 48 (bs,2H) Z 405 ai +73 £ See teeea f Gre hot theo some f co) Predict the structure of following compound Cc g Moleclr formule Cain ° Z ‘Spectral characteristic of compound are as follows 4 AR (em }= 2941,2273,1460 mia Peo, snes? ieee Give appropriate justification for the same. j eI QS B Predict A max forthe folowing compound showing UV absorbance. Justify Your answer : oO TURN OVER ‘AgSIDMBTIIANHILAFCTREDODAITESS ' ' EEGQP. Code :03890 26 A Anower the following any 2); + 08 1) Draw block dlagram showing saya components of Gas chromatography instrumentation. Explain il) Differentiate betwee Stationary phase. b._ Visualization techniques, i) format BPEeU Gon method ed nL sectescp nts ofa mutconpoen formulation 6 © Give IR abortion Frequencies forthe folowing funcional Broups: 8 8) O-H stretch of primary aliphatic aleaha 4) N-Hstreteh of primary aliphatic amine ©) C20 stretch of aliphatic acig A831DS4B7IIABAIIAPCT2EDOBAIFES3Fa6 a) J Ser -MIL CATKT Sub - p’cognasyas , Cage [Time:3Hours} Please check whether you have got the right question paper. Nv.B: 1. All questions are compulsory 2. Write all sub questions together 3. Draw structures & diagrams wherever necessary. [Marks:70} Answer the following. Give structure and sources of catechin ‘Give chemical constituents and source of olive oll Give source & specific chemical test for detection of Purine alkaloids Give biological source and uses of Hypericum, tist the advantages of natural pesticides with a suitable example. Define lodine value and its applications in evaluation of fixed oils. Give the biological source and use of alfa-alfa. Name any one acetylene compound and give the sources of the same, ‘What are glycolipids? Give sources of the same. Name any two alkaloids derived from phenyl alanine. Give the sources of spermaceti wax and its substitutes. Name composition and use of any one marketed preparation containing Aloes, (Give the structure and sources of any one thiophene derivative. What are protoalkaloids? Give a suitable example. “Give composition and uses of any one marketed nutraceutical preparation. Give biosynthesis and source of opium alkaloids. Give binlegical source, chemical constituents and preparation of castor ol Discuss ‘Momordica’ as nutraceutical ive biological sources active constituent and use of cochinea! ‘Give an account of ‘Pyrethrum’ as a natural pesticide. Draw a neat caused diagram of histology of ‘Datura’ ive sources and method of extraction and uses of Pale Catechu ‘Give an account of “zothiocyanate glycosides’. Give the tests for detection of alkaloids Give an account of Ergot alkaloids’. + Give an account of ‘Alkana’. Write a note on Borntrager's test. Give the pharmacognosy of Vasaka!- Give an account of Ginseng. ‘Give methods of preservation of fixed ols 6529FDSDDCIAGTBSESAISIFASEDFSEFD 18