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Chapter 12.4-12.9

1. Differentiate between cis Golgi network (CGN) and trans Golgi network (TGN).
2. Give examples of complex polysaccharides that are synthesized in the Golgi complex.
3. Summarize the
a. Cisternal maturation model
b. Vesicular transport model
4. Discuss briefly the current version of the cisternal maturation model.
5. Why are protein coats of vesicles important?
6. How do adaptors select specific cargo molecules?
7. Discuss the different classes of coated vesicles.
8. Give examples of proteins selected by COPII-coated vesicles.
9. Explain the mechanism by which proteins are maintained in an organelle.
10. Define / give the importance of the following:
a. Rabs
b. SNAREs
11. Explain exocytosis in the context of neurotransmitter release.
12. Describe the distinct roles of lysosomes.
13. Summarize the events that occur during autophagic destruction of a mitochondrion.
14. Describe the distinct roles of vacuoles.
15. How are plant vacuoles similar or different from lysosomes?
16. Differentiate between bulk-phase and receptor-mediated endocytosis.
17. Discuss the importance of:
a. Coated pits
b. Dynamin
c. Phosphoinositides
18. Describe the molecular structure of clathrin and the relationship between its structure and function.
19. Define/give the importance of the following:
a. Housekeeping receptors
b. Signaling receptors
20. Describe the 2 classes of endosomes.
21. What is Niemann-Pick type C disease? Atherosclerosis?
22. What are statins?
23. Differentiate between LDL and HDL.
24. Define:
a. Phagocytosis
b. Phagosome
c. Phagolysosome
25. Give examples of bacteria that are not killed by phagocytic leukocytes.
26. Describe the proteins destined for peroxisomes.
27. Give examples of molecular chaperones that are associated with preparing polypeptides for uptake
by the mitochondria.
28. Describe briefly:
a. OMM
b. IMM
c. TOM complex
d. TIM complex
29. Describe/give the importance of the thylakoid transfer domain