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Updates IN: Fibromyalgia
Updates IN: Fibromyalgia
FIBROMYALGIA
Burckhardt K, Goldenberg D. American Pain Society Clinical Practice Guideline for the Management of
Fibromyalgia Syndrome Pain in Adults and Children, 2005.
FIBROMYALGIA
Fitzcharles MA, Yunnus M. Pain Research and Treatment 2012. doi: 10.1155/2012/184835
FM Clinical Features
PAIN 100%
Fatigue 90%
DIAGNOSIS OF EXCLUSION?
1990 ACR
Widespread Pain of at
least 3 months duration
Left and right side
Above and below the
waist
Axial pain
2
SIS =
2
Detects Fibromyalgia
mSIS >5.75 Assesses for co-morbid
depression
Over-all measure of health
2010 ACR Diagnostic Criteria
0 No problems
1 Slight or mild problems; intermittent
2 Moderate or considerable problems; often present
3 Severe, pervasive, continuous or life-disturbing
problems
2010 ACR Diagnostic Criteria
SYMPTOM SEVERITY Score
Somatic Symptoms Have you had any of the following in
the last 6 months
Blurred vision Wheezing
Dry eyes Anorexia
Tinnitus Nausea
Hearing difficulties Heart burn
Mouth sores Diarrhea
Dry mouth Constipation
Dysgeusia Itching
Headache Hives/ welts
Dizziness Vomiting
Fever Easy bruising
Chest pains Hair loss
Dyspnea Urinary symptoms
2010 ACR Diagnostic Criteria
Symptom Severity
Score (SS)
Widespread Pain Fatigue
Index (WPI) Waking unrefreshed
Cognitive symptoms
Somatic Symptoms
12?
WPI 3-6 and SS Score > 9
SUBSEQUENT VISIT
SS Score to reassess severity
Managing Fibromyalgia
2007 (EULAR)
Carville SF, Arendt-Nielsen S, et al. Ann What?
Rheum Dis 2007; doi:10.1136
2009 (S3)
Hauser W, Eich W, et al. Dtsch Arztebl
Int 2009; 106 (23): 383-91.
2010 (Spain) How?
Alegre de Miguel C, Garcia Campayo J,
et al. Actas Esp Pqiguiatr 2010; 38 (2):
108-20
2012 (Canada)
Fitzcharles MA, Ste-Marie PA, et al. For whom?
What Works (2007)
Intervention LoE / SoR Pain Function
Pharmacologic
Tramadol IB / A
Antidepressants
Amitriptyline, Fluoxetine,
Duloxetine, Milnacipran, IB / A
Moclobemide and
Pirlindole
Pregabalin
Pramipexole IB / A
Tropisetron
What Works (UPDATED)
Drugs LoE Dose Comments
Amitriptyline 1A 10-50 mg Frequent side effects
FDA-approved, Long-term
PREGABALIN 1A 150-450 mg
efficacy
FDA-approved, Long-term
Duloxetine 1A 30-60 mg
efficacy
Milnacipran 1A 25-200 mg FDA-approved
Gabapentin 1B 1200-2400 mg One large RCT
Fluoxetine 2A 20-60 mg Three small RCT
Paroxetine 2B 20 mg One large RCT
Two RCT Tramadol 150 mg +
Tramadol 2B 50-300 mg
Paracetamol 1300 mg
DURATION OF STUDY
< 7 weeks 2 32 -1.16 (-1.86, -0.48) 0.001
7 12 weeks 13 194 -0.24 (-0.50, -0.02) 0.03
> 12 weeks 12 338 -0.24 (-0.40, -0.08) 0.004
FREQUENCY OF TRAINING
1/ week 2 37 -0.07 (-0.52, 03.9) 0.48
2/ week 5 127 -0.69 (-0.95, -0.27) 0.0004
3/ week 16 241 -0.35 (-0.62, -0.09) 0.009
>3/ week 4 142 -0.13 (-0.38, 0.13) 0.33
Sufficient
Improvement Yes Improvement Yes functioning in
at 6 months? 12 months? daily activities/
ADAPTATION
No No
Start Level 2
Interventions
Improvement Yes
at 6months?
No Yes
Multi-modal treatment
Multi-component treatment
Self-management strategies
ANXIETY
State-Trait Personality Inventory
CATASTOPHISM
Coping Strategies Questionnaire
HYPERALGESIA
Pain scale/ Painful Pressure
Group 1 Group 2 Group 3
ANXIETY / DEPRESSION
Moderate High Normal
CATASTROPHISM/ COPING
Moderate High Low
HYPERALGESIA/ TENDER POINTS
Low High High
Giesecke Group 1
Education
Exercise program
For depression
SNRI (Duloxetine, Milnacipran)
and tricyclic antidepressants
For anxiety
Pregabalin, SSRI, SNRI
For hyperalgesia
Pregabalin, gabapentin
Giesecke Group 2
Education
Exercise program
For depression
SNRI (Duloxetine, Milnacipran)
and tricyclic antidepressants
For anxiety
Pregabalin, SSRI, SNRI
For hyperalgesia
Pregabalin, gabapentin
Cognitive Behavior Therapy
Giesecke Group 3
Education
Exercise program
For hyperalgesia
Pregabalin, gabapentin
Do not give SNRI, SSRI, TCA
No Cognitive Behavioral Tx
Dosage of Pregabalin Used (n=1,134)
300
274
250 243
200
150
97 97 98
100 88
68 65
48 56
50
0
25 mg 50 mg 75 mg 100 mg 150 mg 200 mg 225 mg 300 mg 450 mg 600 mg
Dosages of Duloxetine Used (n=1,377)
800
714
700
600
500
400
300 239
194
200
125
100 73
23 2
0
20 mg 30 mg 40 mg 60 mg 80 mg 90 mg 120 mg
Efficacy
40 37
35 34
30
26
25 22
20
20
15 16
15 13
10
10 7
5
0
Major Moderate Slight None Unsure
Duloxetine (n=316) Pregabalin (n=319)
Adverse Events
35
29 30
30 28
26 25 26
25
20 19
16
15
10
0
Severe Moderate Mild None
Duloxetine (n=432) Pregabalin (n=418)
Most Common AEs: Pregabalin
Blurry vision 76
Lack of concentration 81
Dizziness 92
AM Sleepiness 95
Insomnia 57
Brain cloud 72
Dizziness 76
Nausea 89
Increased sweating 90
Decreased libido 97
0 20 40 60 80 100 120
Summary
Described the clinical features of fibromyalgia