Professional Documents
Culture Documents
Background 2
Screening Recommendations/Initial Work-up 2
Diagnosis 3
Treatment
Goals 7
Lifestyle Modifications/Non-Pharmacologic Options 7
Pharmacologic Options 10
Follow-up/Monitoring 12
Evidence Summary/References 12
Clinician Lead and Guideline Development 13
Appendix 1. 6-item Adult ADHD Self-Report Scale 14
Appendix 2. 18-item Adult ADHD Self-Report Scale 15
Guidelines are systematically developed statements to assist patients and providers in choosing appropriate health
care for specific clinical conditions. While guidelines are useful aids to assist providers in determining appropriate
practices for many patients with specific clinical problems or prevention issues, guidelines are not meant to replace
the clinical judgment of the individual provider or establish a standard of care. The recommendations contained in the
guidelines may not be appropriate for use in all circumstances. The inclusion of a recommendation in a guideline
does not imply coverage. A decision to adopt any particular recommendation must be made by the provider in light of
the circumstances presented by the individual patient.
Follow-up studies of children with ADHD have shown that symptoms of the condition persist into
adulthood in 1066% of cases, with an estimated 15% retaining most of their symptoms and an
estimated 50% experiencing persistence of some symptoms. Some symptoms, such as hyperactivity,
tend to decrease with age due to adaptation, neurodevelopment, and self-medication; however, attention
deficit may persist.
The function of individuals who have symptoms of ADHD is significantly dependent upon contextual
factors. While two patients may have a similar score using ADHD evaluation tools, their unique living or
occupational environments may result in differing levels of impairment. For this reason, the diagnosis and
indications for treatment interventions must be determined on an individual basis.
Order an ECG if patient has a past medical or family history of serious cardiac
disease, a history of sudden death in young family members, or abnormal
findings on cardiac examination.
Diagnosis
General Approach
Diagnosis is typically made by a mental health provider. Primary care providers can make a
diagnosis if they have expertise or training in adult ADHD. In addition:
o Masters level therapists can assess for adult ADHD.
o Psychologists can provide additional consultation if the clinical interview and rating scale
data are not sufficient to clarify diagnosis (see Table 3, psychological testing).
o Psychiatrists can provide consultation if there are additional questions regarding
diagnosis/role of comorbid conditions, particularly if there are questions regarding
psychopharmacological management.
Diagnosis is based on comprehensive clinical and psychosocial assessment, impact of symptoms
on functioning, developmental history, and review of rating scales.
Rating scales alone are not sufficient to make a diagnosis of adult ADHD.
Contextual factors play a significant role in determining an individuals level of functioning. While
two patients may have a similar ADHD severity level, their different living or occupational
environments may result in different levels of difficulty or impairment.
Diagnosis requires determining that symptoms:
o Began in childhood and have persisted through life, and
o Are not explained by other diagnoses, and
o Have resulted in, or are associated with moderate or severe psychological, social, and/or
educational or occupational impairment.
ADHD Diagnosis and Treatment Guideline: Adults 3
Table 3. Diagnosis of ADHD
Diagnostic approach Action
Assess clinical and psychosocial Assess current mental status and review behavioral and symptomatic
status concerns in the different settings of the persons life.
Establish developmental history of Establish history of ADHD symptoms in childhood (preferably before
ADHD the age of 7), either retrospectively or prospectively.
Preferred: Use behavioral symptoms noted in school records or information
from parents or sibling.
Acceptable: Use patient self-report when collateral information is not
available.
Assess impact of symptoms on Confirm symptoms have clinically significant impact on social,
functioning educational, or occupational functioning.
and
Confirm impairment exists in at least two different, important settings
(e.g., home and work).
Use rating scale Use the 18-item Adult Self-Report Scale (ASRS-v1.1, Appendix 2); consider
likelihood of ADHD if score on part A is 4 or more. The frequency scores in
part B provide additional cues and can serve as further probes into the
patients symptoms.
Collect observer reports Use interview or rating scale to corroborate presence of ADHD symptoms.
(e.g., partner, parent, friend) Consider using the full version of the ASRS and modifying the language for
observer usage.
Rule out psychiatric comorbidities Many psychiatric conditions have symptoms of impairment in attention,
concentration, difficulty with task completion, or inappropriate behavior.
Assess presence of comorbid symptoms:
Depression (PHQ-9)
Alcohol (AUDIT)
Drug misuse (DAST-10)
Anxiety (GAD-7)
As appropriate, also assess for symptoms of bipolar disorder.
Psychological testing Testing is typically not necessary to diagnose ADHD.
Patients with adult ADHD frequently have difficulties with what is referred to
as executive function (e.g., impulse control, organization and planning,
working memory, sustained attention). But not all adults with ADHD have
these difficulties, and there are adults who have executive functioning
deficits who do not have ADHD (i.e., difficulties may be associated with a
learning disability or history of brain trauma).
1
Additional scales that might be helpful in certain circumstances:
Barkley Adult ADHD Rating Scale IV (BAARS IV), which has normative information by specific age group,
ADHD subtype (e.g., inattentive, hyperactive/impulsive, and combined), and retrospective report (i.e., presence
of symptoms in childhood).
Achenbach adult rating scales, if there is need for a rating scale to assess severity of a wide range of mental
health symptoms.
Not recommended (diagnostic testing): Brain imaging (e.g., SPECT, PET scan, MRI, or CT) is not
recommended for diagnosing adult ADHD.
1. Six (or more) 2 of the following symptoms of inattention have persisted for at least
6 months to a degree that is maladaptive and inconsistent with developmental level:
Often fails to give close attention to details or makes careless mistakes in
schoolwork, work, or other activities.
Often has difficulty sustaining attention in tasks or play activities.
Often does not seem to listen when spoken to directly.
Often does not follow through on instructions and fails to finish schoolwork, chores,
or duties in the workplace (not due to oppositional behavior or failure to understand
instructions).
Often has difficulty organizing tasks and activities.
Often avoids, dislikes, or is reluctant to engage in tasks that require sustained
mental effort (such as schoolwork or homework).
Often loses things necessary for tasks or activities (e.g., toys, school assignments,
pencils, books, or tools).
Is often easily distracted by extraneous stimuli.
Is often forgetful in daily activities.
or
2. Six (or more) of the following symptoms of hyperactivity-impulsivity have persisted for at
least 6 months to a degree that is maladaptive and inconsistent with developmental level:
Hyperactivity
Often fidgets with hands or feet or squirms in seat.
Often leaves seat in classroom or in other situations in which remaining seated is
expected.
Often runs about or climbs excessively in situations in which it is inappropriate (in
adolescents or adults, may be limited to subjective feelings of restlessness).
Often has difficulty playing or engaging in leisure activities quietly.
Is often "on the go" or often acts as if "driven by a motor."
Often talks excessively.
Impulsivity
Often blurts out answers before questions have been completed.
Often has difficulty waiting turn.
Often interrupts or intrudes on others (e.g., butts into conversations or games).
Additional criteria
Some hyperactive-impulsive or inattentive symptoms that caused impairment were
present before age 7.
Some impairment from the symptoms is present in two or more settings (e.g., at
school/work and at home).
There must be clear evidence of clinically significant impairment in social,
academic, or occupational functioning.
1
When DSM-V is published in 2013, the following changes are expected:
The three subtypes of childhood ADHD will no longer be identified as separate conditions.
The age of onset will be extended up to age 12.
Reduction of symptom threshold for diagnosis from six to four symptoms.
2
European Consensus Statement established that a threshold of four out of nine symptoms in the DSM-IV criteria of
either domain of inattention or hyperactivity-impulsivity is sufficient to indentify impairment in adults with a history of
childhood onset and significant impairment.
Goal
The primary goal of treatment is to minimize the impact of ADHD symptoms on patient functioning while
maximizing the patients ability to compensate or cope with any remaining difficulties.
General Approach
If the patient has comorbid conditions, treat the more severe disorder(s) first. For example, if the
patient is both depressed and has ADHDand if the ADHD is having the biggest impact on the
patients functioningtreat ADHD first.
Once the most severe disorder is treated, it is important to continue treatment of other comorbid
disorders (e.g., depression and ADHD both need to be treated in order to maximize treatment
effectiveness).
Education about ADHD is essential to assist the patient in making informed decisions about
pharmacotherapy and the importance of behavioral and lifestyle changes.
Pharmacotherapy should be considered one component of a comprehensive treatment program
that addresses psychological, behavioral, educational, or occupational needs.
Optimally, CBT should be combined with pharmacological treatments that improve the core ADHD
symptoms of inattention, impulsivity, hyperactivity, and/or distractibility.
CBT framework
The basic framework/rationale for CBT is as follows:
Adults with ADHD have had core impairments since childhoodsuch as distractibility,
disorganization, difficulty with following through on tasks, and impulsivitythat prevent them from
learning or using effective coping skills to deal with basic life tasks (e.g., work, school, and
relationships).
The lack of effective coping skills over time leads to repeated failure experiences and chronic
underachievement. This results in an inability to manage symptoms and continued functional
impairment.
As a result of this chronic failure, adults have received much negative feedback from their
parents, partners, teachers, and peers, leading to negative thoughts and feelings (e.g., I am no
good, I am a failure). These negative feelings can result in an avoidance of coping efforts out of
fear of failure and lead to comorbid disorders such as depression or anxiety.
Studies and reports on complementary/alternative treatments for ADHD have only featured child subjects.
According to the organization Children and Adults with Attention Deficit/Hyperactivity Disorder (CHADD),
the following have not been shown to be effective:
Elimination of sugar, salicylates, or artificial coloring from diet
Nutritional supplements such as glyconutritional supplements, fatty acid supplementation,
megadose vitamins, amino acid supplementation, or herbals
Sensory integration training
Antimotion sickness medication
Anti-fungal medication for Candida
Chiropractic treatments
Optometric vision training
Metronome training
Neurofeedback
Initiate ADHD medications at the lowest possible dose and titrate slowly. Before switching
medications, titrate to the maximum dose (if there are no side effects).
For information on side effects, contraindications, formulary status (e.g., prior authorization), and other
pharmacy-related issues, see the Group Health Formulary, the Healthwise Knowledgebase, or other
resources.
2nd line 2
Alternative recommendation unless patient has a history of substance misuse or diversion with risk for relapse,
or a cardiac or other medical condition for which stimulants would be contraindicated.
Methylphenidate HCL ER 10 mg daily in the Increase by 10 mg every 60 mg
morning 7 days as needed.
or
Methylphenidate HCL ER 18 mg daily in the Increase by 18 mg every 72 mg 3
(generic Concerta) morning 7 days as needed.
or
Dextroamphetamine SR 10 mg daily in the Increase by 10 mg every 40 mg
morning 7 days (typically dosed twice
daily) as needed.
3rd line
First-line for patients if stimulants are contraindicated (e.g., cardiac condition or history of substance misuse or
diversion).
Atomoxetine (Strattera) [PA] 4 40 mg daily in the Increase to 80 mg after 100 mg
morning 3 days. May increase to
100 mg after 24 additional
weeks as needed.
Medication Monitoring
Evidence Summary/References
This guideline was adapted from the following evidence-based guidelines:
Canadian Attention Deficit Hyperactivity Disorder Resource Alliance (CADDRA). Canadian ADHD
Practice Guidelines, Third Edition. 2011. Available online at:
http://www.caddra.ca/cms4/pdfs/caddraGuidelines2011.pdf [PDF]
Kooij S, Bejerot S, Blackwell A, et al. European consensus statement on diagnosis and treatment
of adult ADHD: The European Network. BMC Psychiatry. 2010;10:67. Available online at:
http://www.biomedcentral.com/content/pdf/1471-244x-10-67.pdf [PDF]
Nutt DJ, Fone K, Asherson P, et al. Evidence-based guidelines for management of attention-
deficit/hyperactivity disorder in adolescents in transition to adult services and in adults. J
Psychopharmacol. 2007;21(1):1041. Available online at:
http://www.bap.org.uk/pdfs/ADHD_Guidelines.pdf [PDF]
Last Update
Most recent comprehensive literature review: February 2011
Interim update: October 2011
Process of Development
This guideline was adapted from the following evidence-based guidelines:
Canadian Attention Deficit Hyperactivity Disorder Resource Alliance (CADDRA), CADDRA ADHD
guidelines (2011)
European consensus statement on diagnosis and treatment of adult ADHD (2010)
National Institute for Health and Clinical Excellence (NICE), attention deficit hyperactivity
disorder: diagnosis and management of ADHD in children, young people and adults (2008)
British Association of Psychotherapists, evidence-based guidelines for management of attention-
deficit/hyperactivity disorder in adolescents in transition to adult services and in adults (2007)
The following specialties were represented on the Group Health development teams: behavioral health,
family medicine, pediatrics, and pharmacy.
Sometimes
Very Often
scale on the right side of the page.As you answer each question, place an X in the box that
best describes how you have felt and conducted yourself over the past 6 months. Please give
Rarely
Never
Often
this completed checklist to your healthcare professional to discuss during todays
appointment.
1. How often do you have trouble wrapping up the final details of a project,
once the challenging parts have been done?
2. How often do you have difficulty getting things in order when you have to do
a task that requires organization?
3. How often do you have problems remembering appointments or obligations?
4. When you have a task that requires a lot of thought, how often do you avoid
or delay getting started?
5. How often do you fidget or squirm with your hands or feet when you have
to sit down for a long time?
6. How often do you feel overly active and compelled to do things, like you
were driven by a motor?
Part A
7. How often do you make careless mistakes when you have to work on a boring or
difficult project?
8. How often do you have difficulty keeping your attention when you are doing boring
or repetitive work?
9. How often do you have difficulty concentrating on what people say to you,
even when they are speaking to you directly?
10. How often do you misplace or have difficulty finding things at home or at work?
11. How often are you distracted by activity or noise around you?
12. How often do you leave your seat in meetings or other situations in which
you are expected to remain seated?
14. How often do you have difficulty unwinding and relaxing when you have time
to yourself?
15. How often do you find yourself talking too much when you are in social situations?
16. When youre in a conversation, how often do you find yourself finishing
the sentences of the people you are talking to, before they can finish
them themselves?
17. How often do you have difficulty waiting your turn in situations when
turn taking is required?
18. How often do you interrupt others when they are busy?
Part B
DA-1833 Rev. Date 2011133