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Data Pengamatan Modul 4
Data Pengamatan Modul 4
100
Total FG : 500 = 666,67
75
25
Asetonitril : 100 666,67 = 166,67
Waktu Retensi
C (ppm) AUC
(menit)
0 6974068 2,08
0,1 125693975 2,07
0,5 141875212 2,067
1 153665588 2,067
5 144740094 2,067
10 144019223 2,067
20 143719515 2,067
50 140287221 2,067
a = 155087860,5
b = -2717479,332
r = -0,905
GRAFIK
Regresi Linear-Siprofloksasin
180000000
160000000
140000000 y = -2717479,33x + 15508760,5
120000000 R = 0,905
Luas Area
100000000
80000000 Regresi Linear
60000000
Linear (Regresi Linear)
40000000
20000000
0
0 20 40 60
Konsentrasi (ppm)
a. Konsentrasi Sampel 1
y = a + bx
51549754 = 155087860,5 - 2717479,332 x
2717479,332 x = 155087860,5 51549754
103538106,5
= = 38,100 g/ml
2717479,332
b. Konsentrasi Sampel 2
y = a + bx
50503617 = 155087860,5 - 2717479,332 x
2717479,332 x = 155087860,5 50503617
10458243,5
= = 38,49 g/ml
2717479,332
c. Konsentrasi Sampel 3
y = a + bx
45024317 = 155087860,5 - 2717479,332 x
2717479,332 x = 155087860,5 45024317
110063543,5
= = 40,50 g/ml
2717479,332
d. Konsentrasi Sampel 4
y = a + bx
46985763 = 155087860,5 - 2717479,332 x
2717479,332 x = 155087860,5 46985763
108102097,5
= = 39,78 g/ml
2717479,332
e. Konsentrasi Sampel 5
y = a + bx
51326963 = 155087860,5 - 2717479,332 x
2717479,332 x = 155087860,5 51326963
103760897,5
= = 38,18 g/ml
2717479,332
f. Konsentrasi Sampel 6
y = a + bx
36750859 = 155087860,5 - 2717479,332 x
2717479,332 x = 155087860,5 36750859
118337001,5
= = 43,55 g/ml
2717479,332
Pengenceran Cp
Sampel AUC C (g/ml)
(x10) (mg/ml)
Blanko 393684614 - - -
1 51549754 38,1 381 0,0381
2 50503617 38,49 384,9 0,0384
3 45024317 40,5 405 0,0405
4 46985763 39,78 397,8 0,0397
5 51326963 38,18 381,8 0,0381
6 36750859 43,55 435,5 0,0453
Sebelum
140 mL - - - - - -
minum obat
11.00 14.00 190 mL 7,24 mg 3 1,5 3 2,413 0,88
14.00 17.00 130 mL 4,992 mg 3 4,5 6 1,664 0,509
17.00 20.00 180 mL 7,29 mg 3 7,5 9 2,43 0,88
20.00 23.30 150 mL 5,955 mg 3,5 10,75 12,5 1,7 0,53
05.30 08.00 240 mL 9,144 mg 2,5 16,75 21 3,66 1,3
08.00 11.00 250 mL 10,875 mg 3 22,5 24 3,63 1,29
25
20
t Mid (jam)
y = 16.053x - 3.8348
15
R = 0.5025
10 Series1
5
Linear (Series1)
0
0 0.5 1 1.5
Ln Du / t (mg/ml)
Regresi tmid Vs ln Du/t
a = -3,834
b = 16,052
r = 0,708
y = a + bx
Persamaan
ln Du/t = ln Ke . Xo K . tmid
ln Du/t = -3,834 16,052 . tmid
K = 16,052/jam
0,693 0,693
T1/2 = = = 0,043
16,052
- Metode ARE
Regresi t* Vs ln ARE
a = 4,425
b = -0,142
r = -0,874
y = a + bx
y = 4,425-0,142 x
20
t * ( Jam)
15
t* vs Ln ARE
10 Linear (t* vs Ln ARE)
5
0
0 1 2 3 4
Ln ARE (mg)
Persamaan
( )
d = ln .
= 4,425 0,142 . t
K = 0,142/Jam
0,693 0,693
T1/2 = = = 4,880
0,142