Hyaluronic Acid

5/11/2017 Hyaluronic Acid C Tht S L Thnh Phn Chng Lo Ha Tt?
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CHM SC DA CHNG LO HA
Hyaluronic Acid C Tht S L Thnh

Phn Chng Lo Ha Tt?
3 0 1844 2 nm trc
Nhc n cc sn phm chng lo ha, chng ta thng gp sai lm khi chi tiu nhiu tin vo nhng sn
phm khng ng. l v qu nhiu thng tin sai lch trn mng v cc thnh phn chng lo ha trong m
phm. Bn cnh , vi mi ln mua sn phm []
Thch Chia s 126 ngi thch ni dung ny. Hy l ngi u tin trong s bn
b ca bn.
Nhc n cc sn phm chng lo ha, chng ta thng gp sai lm khi chi tiu nhiu tin vo
nhng sn phm khng ng. l v qu nhiu thng tin sai lch trn mng v cc thnh phn
chng lo ha trong m phm. Bn cnh , vi mi ln mua sn phm chng lo ha, chng ta
phi mt mt thi gian di mi c th kim nh c cht lng ca sn phm . l l do
chng ta s tp trung vo tng thnh phn c th v chng lo ha. V thnh phn hm nay chng
ta s tm hiu l Hyaluronic Acid (HA)
https://www.happyskin.vn/hyaluronic-acid-co-that-su-la-thanh-phan-chong-lao-hoa-tot 1/16
Nhc n cc sn phm chng lo ha, chng ta thng gp sai lm khi chi tiu nhiu tin vo
nhng sn phm khng ng
Hyaluronic Acid l g?
Hy ngh Hyaluronic Acid l mt phn t ng ln, theo tn gi ha hc l Polysaccharide. y l
mt phn t ng ln. ng thng thng c khi lng phn t 340 n v Dalton. Cn HA c
khi lng ln n 600.000 n 1.000.000 n v. Cu trc phn t v trng lng ln ny mang li
cho HA kh nng gi gi nc gp 500 n 1000 ln trng lng ca mnh. l l do v sao c th
chng ta s dng HA dng m v bi trn cc m khp trong c th.
Hyaluronic Acid l mt phn t ng ln
Hyaluronic Acid vi nhiu tn gi

u tin hy bt u vi nhng ci tn. V tn gi n l Hyaluronic Acid nn chc chn y l mt
dng axit. Mt dng thc khc l mui natri hay cn gi l Sodium Hyaluronate. Hai dng thc ny
c th c s dng thay th cho nhau. i khi chng ta cng c th gi tt c cc dng thc HA l
Hyaluronan. Kt li th HA c 2 dng thc thay th chnh l:
Sodium acetyl hyaluronate

Hydrolyzed hyaluronic acid
Ngun gc ca Hyaluronic Acid

C th tr li nhanh chng l t ng vt. t nht th HA cng tm c trong c th ca ng vt c
v, cn cc loi b st v c th khng chc chn. Hy nhn qua mt cht v lch s ca HA t khi
thnh phn ny c pht hin.
t nht th HA cng tm c trong c th ca ng vt c v
Nm 1934, HA ln u c c tch ra t mt ca con b v n c t tn theo hyaloid

c ngha l trong sut nh thy tinh (HA thuc dng gel nn n kh sch v trong sut nh
thy tinh)
1930 1940: HA c tch ra t nhiu ngun gc khc nhau bao gm c dy rn v mo g
1951: Cc nh khoa hc u tin xc nh cu trc ca HA
1970s: Con ngi bt u nhn ra HA l mt cht bi trn tc ng tt n sn trong c th
1980s: ng dng u tin ca HA vo m phm. Khi HA ln u tin c cho vo sn phm
chng lo ha th ti ang lm vic ti mt cng ty m phm cao cp kh nh v h s
dng n. Vo thi im th gi ca n rt mc v n c ly ra t mo g, theo ti nh th
n khong $500/kg hoc c th hn.
1999: Cc nh nghin cu tm ra cch nhn bn HA t vi khun (c th th l nhm
Group A Streptococcus). Vi khun thng c khi lng phn t thp nhng n r hn so vi
HA tch ra t trong mo g v n cng khng lin quan n ngun gc ng vt. Tuy nhin, n
cng c th nguy hi v ri ro nhim c t lin khun cu.
2003: FDA Cc qun l thc phm v dc phm Hoa K ph duyt chp thun HA nh mt
dng thuc tim lm y cc np nhn
Nm 2010 v xa hn, trong vi nm gn y, mt phng php mi c pht trin lm
ra HA t mt chng vi khun lnh tnh c gi l Bacillus subtilis. V vy, ngy nay HA khng
cn b nhim khun, khng c ngun gc t ng vt v c lm nn m khng c s tr
gip t cc dung mi hu c.
HA c dng lm g?
Chng ta nhc n vic HA c pht hin nhng khuc vc c nhiu cht lng ca mt v trong
cc khp c l l do m n kh nng tr nc kh cao, HA kh nhn v c st, nhng n c
th ha lng trong qu trnh c gi l ng sut trt (shear stress) nn HA cn c xem nh
cht bi trn sinh hc l tng. Trung bnh c th ngi c khong 15gram HA v khong tm 1/3
trong s c s dng mi ngy. C nhng enzim sn xut nn HA nhng cng c nhng enzim
ph v n HA c th lin tc c ti to.
Cng c nhng cch hiu qu phc hi nhng HA mt i trong mt s trng hp. V d nh,
c th tim HA vo xng khp iu tr vim xng khp (cng c th hp th n qua ng tiu
ha nhng s khng hiu qu bng cch tim trc tip). Trong trng hp phu thut cc chng
bnh v mt nh cha c thy tinh th, cy ghp gic mc th HA cng c s dng tim trc
tip vo mt. Mt iu hin nhin, khng th thiu khi k n vic HA cn c tm thy trong da,
ni m n c nhim v lm y v y li cc np nhn
Theo thi gian c th ngi s sn xut t Hyaluronic Acid hn trc v cng l nguyn nhn xut
hin cc np nhn trn da. iu dn n mt cu hi quan trng. Vy tht s Hyaluronic Acid c
l mt thnh phn chm sc da tt? C n 3 hoc 4 cu tr li cho cu hi bi v bn c th
phc hi HA bng nhiu cch khc nhau
Theo thi gian c th ngi s sn xut t Hyaluronic Acid hn trc v cng l nguyn nhn xut
hin cc np nhn trn da
N c s dng nh mt cht tim lm y, mt loi kem dng m, mt thnh phn giao tip t
bo v thc phm chc nng. Hy nhn vo nhng tc ng m HA li trn ln da. Chng ta s
i tm li gii cho ba cu hi: HA hot ng nh th no, vi thnh phn c th ngm vo da khng,
v liu c bt k nghin cu ng tin cy no ni v vic HA c hiu qu vi con ngi.
Hy bt u bng vic ni v Hyaluronic Acid nh

mt cht tim lm y
Lun lun d dng khi ni v mt tr liu c chp thun bi FDA v bn bit y, c rt nhiu
nghin cu ng sau n. Trong trng hp ny chng ta bit c, tim hyaluronic acid tht s hiu
qu trong vic xa m cc np nhn. C ch ch n gin l lc vt l ca mt polymer c khi
lng phn t cao v lng cht s xuyn qua lp da bi cy kim tim, bng cch ny th n tht
s hiu qu trong vic lm y cc np nhn v n thng ko di trong su thng.
Trong trng hp ny chng ta bit c, tim hyaluronic acid tht s hiu qu trong vic xa m
cc np nhn
Cng nh collagen hoc bt k dng cht no khc, bn phi tm n cc chuyn gia c th thc
hin iu tr, phng php ny th c th kh tn km v phi c lm li cch vi thng mt ln.
Cho d cch ny hiu qu nhng cch ny khng dnh cho tt c mi ngi.
Hyaluronic Acid c phi l cht dng m
C ch hot ng ca n ?
C ch hot ng ca qu trnh dng m l HA cha c n 1000 ln trng lng trong

nc. iu ny rt phi thng khi mt cht polymer c th gi c nhiu nc nh vy.
Liu n c thm thu?

V loi dng m ny hot ng hiu qu trn b mt da, HA cng khng cn phi thm nhp vo
su bn trong c th hot ng c. HA ch phigi li c trn b mt da. iu cng c
ngha l nn dng cc sn phm cha HA c th lu li trn da mt lng ng k ch ng lng
ph tin vo cc sn phm cha HA ch ra mt hoc ch s dng mt lng t nh l toner.
c nghin cu no chng minh HA trn da tht s hiu qu?

C. Mt v d v nghin cu ca Shiseido vo nm 1999 v cc cc tc dng dng m ca HA
phin bn Sodium Acetyl trn da chut lang. Khng kh chng minh iu ny bng cch s dng
cc cng ngh khc nhau.
Mt lo ngi th v c a ra v HA v cc thnh phn khc nh glycerin v vic vn chuyn

nc cho da: Trong iu kin kh hu hanh kh, rt t m trong khng kh, nhng thnh phn ny
c th dn n vic thot hi nc trn mt. Ni cch khc nhng thnh phn ny c th lm da bn
tr nn kh hn. Cch bo v tt nht l khng da vo cc serum nn Hyaluronic acid hoc
glycerin. Thay vo c th s dng kem dng hoc lotion kha nc cho da ca bn.
Cch bo v tt nht l khng da vo cc serum nn Hyaluronic acid hoc glycerin
Ni tm li, HA c th l mt thnh phn dng m kh tt nhng cng cn rt nhiu thnh phn

dng m khc ngoi kia. Nu bn ang nung nu nh chi tin cho mt sn phm cha
Hyaluronic acid th hy t nht hy m bo rng n cha mt lng HA ln. V vy, bn cn phi c
nhn hiu sn phm k cng. y l mt v d:
Sephora bn sn phm Peter Thomas Roth VIZ-1000 75% Complex Hyaluronic Acid. Khi nhn thy
l dng m ny ti ngh tht tuyt, n cha mt lng HA nng cao. Nhng khi nhn vo
danh sch thnh phn vi mt lot cc cht chit xut c lit k u tin v HA ch c lit k
nh l thnh phn th 25 hoc 26. HA gn nh nm cui cng trong danh sch. Nu y thc s l
mt sn phm cha 75% HA th n phi l thnh phn u tin hoc th hai. Vn y l g? 75%
Complex Hyaluronic Acid. Cc nh sn xut ly axit hyaluronic trn cng mt lot cc cht chit
xut khng c tc dng g, v qung b l s dng 75% hn hp ny trong cng thc. iu l gii
c vic thc ra sn phm khng h cha mt lng ca HA hu dng! y c th l mt sn phm
tt nhng tht l cch qung co khng r rng.
So snh vi mt sn phm khc, hy nhn vo SkinCeuticals Hydrating Gel B5. Thm ch khng
cHA trong tn gi, nhng n li l thnh phn th hai trong danh sch cc thnh phn ca sn
phm. Tt nhin n vn c th c s dng mc thp nhng phi nh gi cao s khc bit
trong cch qung co sn phm n vi ngi tiu dng.
Hyaluronic acid l mt thnh phn giao tip t bo
C ch hot ng?
Thnh phn giao tip t bo khng ch hot ng vi vai tr l cht dng m b mt, n cn c th
nh hng n cu trc sinh hc nm di lp da. y, ti dng t c th bi v cc thng tin v
cc thnh phn trn vn cn s si v ty thuc vo hiu qu xem n l dc phm. Tuy nhin,
vn c nhng bng chng v mt s thnh phn hot ng theo cch ny. ng ngc nhin, HA c
th c k n trong hng mc ny.
Mt nghin cu c thc hin ti i hc Regensburg c, c tnh tc dng ca HA c thy

phn (Hydrolyzed Hyaluronic Acid) trn biu hin gen. H thy rng HA c thy phn thay i
hn 40 gen, bao gm nhng gen chu trch nhim lin kt cc t bo.
Mt nghin cu trong ng nghim cho thy thnh phn HA c b sung c th gip kch thch sn
sinh collagen. Nhng iu ny ch c thc hin trn cc t bo trong phng th nghim v n
cng cha a n kt qu cui cng. Bn cnh , chng phi khi lng HA qu ln thm thu
vo da?
Liu HA c thm thu?

Ti tht s kinh ngc khi nhn ra HA c th thm thu vo da! Ti sao iu ny li ng ngc nhin
nh vy? u tin, phi ni rng kch thc phn t HA qu ln, ng knh khong 3.000 nm, cn
khong cch gia cc t bo da ch t 15 -50nm. V mt l thuyt th mt phn t ln nh HA nh
vy khng th thm thu vo da. Mt iu na, HA l phn t a nc m chng ta u bit
thm thu qua da th cc cht thng phi l thnh phn a du hn. l l do v sao s dng sn
phm cha AHA th tt cho vic ci thin b mt da cn sn phm cha BHA li hiu qu hn vi
cng dng lm sch su tr cc vn v mn.
Nhng ha ra th c hai cch HA c th thm thu c. Th nht, nghin cu gn y trong HA

c thy phn cho thy rng n c th c lm nh li lun lch gia cc khoang gian
bo. HA thy phn ny c chia nh thnh tng mnh vi khi lng phn t khong 50 kDaltons.
Cc nh nghin cu nhn ra rng n c th thm nhp vo tai ln. (nghin cu caEvonik)
V th hai, qu l mt c sc ln khi bit rng ngay c phn t c ln v a nc cng c th thm

nhp c v c tnh ca phn t. Nghin cu nm 1999 ca tp ch Journal of Investigative
Dermatology vi ta S hp thu ca hyaluronan trn ln da nguyn vn. Cc nh nghin cu
gn ui phng x vo HA (mt cch thc cho php pht hin cc chuyn ha hoc cc qu trnh
ha hc ca cht/vt c theo di) ri thoa ln chut tri lng v da tay ngi. Kt qu cho thy
c chut v ngi, HA c th thm nhp su vo lp biu b, h b v cc t bo ni m bch huyt.
H cng tm thy cht chuyn ha HA trong mu v nc tiu ca chut. y l nghin cu u tin
v duy nht cho chng ta thy rng vi mt HA c kch thc y thm su vo lp h b v c
tch t trong mt thi gian ngn trc khi b phn hy bi cc enzim. Cc nh nghin cu cng cho
rng, lng HA xm nhp c lp h b khng ln v n khng tn ti lu. Nhng HA thc s
c th thm thu qua da!
C nghin cu no chng minh rng n hot ng?

Tnh nng giao tip t bo ca hyaluronic acid c v cha c nghin cu y nhng chng ti
tm thy mt vi t liu c lin quan. Mt thi gian di, cc th nghim trn cch sinh vt sng
nh gi mc nh hng ca HA thy phn i vi n hi v th rp ca da. H nhn ra khi c
HA, th tnh n hi c tng ng k (khong 14%) v gim hn th nhm ca ln da (khong
10%). khng phi mt tc ng qu ln nhng li rt th v.
Mt nghin cu khc t t The Journal of Clinical and Aesthetic Dermatology a ra mt ci nhn

y ha hn bi v cho thy rng HA c th tng cng m cho da, gim vim, c cc tc dng
giao tip t bo, v gip ngn nga vic mt m.
Cui cng, chng ti tm thy mt nghin cu trn phn t HA vi kch thc phn t cc nh nano,
gim n 5nm v vy n c th thm qua da. Nhng nghin cu ny tnh xc thc khoa hc cha
cao v ngi ta ch dng mt loi kem cha HA trong vi tun v kt qu c so snh vi ln da
khng c s dng.
Mc d chng ta cn thm nhng nghin cu r rng hn, c v nh hyaluronic acid l mt cht

giao tip t bo.
Hyaluronic Acid l thc phm b sung c th tiu

ha c
C ch hot ng?
Cui cng chng ta hy ni v HA nh l mt thnh phn b sung vo ch n ung (thc phm
chc nng). Chng ti tm thy mt nghin cu mang tn Thc n cha HA tm thy trong da ca
chut cho thy khi nhng con chut tiu th HA c gn ui phng x bng ng ming, HA
xut hin trn ln da ca chut. Khong 90% HA b ph hy trong h tiu ha nhng mt s khc
n c h b.
Khong 90% HA b ph hy trong h tiu ha nhng mt s khc n c h b
Liu n thm thu?

V HA tm thy trong mu v da sau khi n hoc ung, c v nh n hp th c thng qua h tiu
ha.
C nghin cu chng minh n hot ng?

Bn cnh nghin cu ny trn chut, chng ti khng th tm thy bt k nghin cu v li ch ca
vic hp th hyaluronic acid theo ng tiu ha vo ln da ngi. iu tt nht chng ti c th
tm c mt phn tch vo nm 2015 ca cc nghin cu s dng hyaluronic acid iu tr vim
xng khp. Theo cc nh nghin cu Mc d Vin Phu thut chnh hnh ca M phn i vic s
dng hyaluronic acid trong vim khp M, mt s nh gi li tm thy li ch ca HA vi u gi.
Kt lun
Hyaluronic acid chc chn lm vic nh l mt cht tim lm y hiu qu nhng khng dnh cho
tt c mi ngi.
Phn t Hyaluronic acid l cht dng m tt nhng li kh t tin hn so vi nhiu loi khc
Hyaluronic acid c th, lp li l C TH c c tnh chng lo ha ngoi mong i nhng tc dng

vn cha c tm hiu trn vn .
C mt c ch gii thch lm th no HA c th c ch cho da khi hp th qua ng tiu ha

nhng chng ti vn cha th tm thy bt k nghin cu ng tin cy minh chng iu ny trn
ngi tht.
(Ngun:
Thebeautybrains.com (https://thebeautybrains.com/2015/03/is-hyaluronic-acid-a-good-anti-aging-
ingredient/)
)
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Thch Chia s 126 ngi thch ni dung ny. Hy l ngi u tin trong s bn
b ca bn.
3 0 1844
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5/11/2017 Hyaluronic Acid C Tht S L Thnh Phn Chng Lo Ha Tt?

Skin Store M phm chnh hng (https://skinstore.vn)

Happy Skin Mobile App ng dng trn iOS v Android (https://bnc.lt/m/z0iTIFLc0r)

Hyaluronic Acid C Tht S L Thnh

Hyaluronic Acid l mt phn t ng ln

Hyaluronic Acid vi nhiu tn gi

Sodium acetyl hyaluronate

Ngun gc ca Hyaluronic Acid

t nht th HA cng tm c trong c th ca ng vt c v

Nm 1934, HA ln u c c tch ra t mt ca con b v n c t tn theo hyaloid

Hy bt u bng vic ni v Hyaluronic Acid nh

Hyaluronic Acid c phi l cht dng m

C ch hot ng ca qu trnh dng m l HA cha c n 1000 ln trng lng trong

Liu n c thm thu?

c nghin cu no chng minh HA trn da tht s hiu qu?

Mt lo ngi th v c a ra v HA v cc thnh phn khc nh glycerin v vic vn chuyn

Cch bo v tt nht l khng da vo cc serum nn Hyaluronic acid hoc glycerin

Ni tm li, HA c th l mt thnh phn dng m kh tt nhng cng cn rt nhiu thnh phn

Hyaluronic acid l mt thnh phn giao tip t bo

Mt nghin cu c thc hin ti i hc Regensburg c, c tnh tc dng ca HA c thy

Liu HA c thm thu?

Nhng ha ra th c hai cch HA c th thm thu c. Th nht, nghin cu gn y trong HA

V th hai, qu l mt c sc ln khi bit rng ngay c phn t c ln v a nc cng c th thm

C nghin cu no chng minh rng n hot ng?

Mt nghin cu khc t t The Journal of Clinical and Aesthetic Dermatology a ra mt ci nhn

Mc d chng ta cn thm nhng nghin cu r rng hn, c v nh hyaluronic acid l mt cht

Hyaluronic Acid l thc phm b sung c th tiu

Khong 90% HA b ph hy trong h tiu ha nhng mt s khc n c h b

Liu n thm thu?

C nghin cu chng minh n hot ng?

Hyaluronic acid c th, lp li l C TH c c tnh chng lo ha ngoi mong i nhng tc dng

C mt c ch gii thch lm th no HA c th c ch cho da khi hp th qua ng tiu ha

Xem review mt s sn phm cha Hyaluronic Acid ti Happyskin

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