Reese Paha SLE td isis t eile ras sy) aR Enh bo History History Department of Bioscience and Biotechnology (DBB) This department that offers bachelor, master, and doctoral degrees was born in 2013 after combing the Graduate Institute of Bioscience and Biotechnology established in 1993 and the Department of Life Sciences established in 2005. After finishing their base courses on chemistry, physics, biology and biostatistics, undergraduate students may explore all fields of Bioscience at molecular, cellular, physiological, and evolutionary levels by taking a group of well-designed advanced courses, including lecture and laboratory training according to their own interests. DBB requires students to actively engage in research by conducting independent research projects at a laboratory of their choices. Students are also required to join training seminars to increase their ability to present their thoughts Before earning their master or doctoral degrees,graduate students must conduct intensive independent research within the following four programs. Molecular and cellular biology: This program is concentrated on immune cell activation, apoptosis and gene therapy, stem cell culturing and relevant applications, cancer, neuron-degeneration, metabolic diseases and inflammation. Research findings have been published in prestigious journals such as Transgenic Research. Developmental biology: This program is focused on hypoxia, gene regulation, signal transduction and carcinogenesis, animal embryonic developments, transgenic fish model systems, and reproductive physiology. Research findings have been published in esteemed journals such as Cell Death and Development and Develapment Dynamics, and Molecular Carcinogenesis. Chemical biology: This program is centered on cellular-methylation and DNA-repair mechanisms, biological anti-oxidation systems, environmental analytical chemistry. nano-biotechnology, and biomedical materials. Research findings have been published in distinguished journals such as Biosensors and Bioelectronics Journal of Nanomaterials Aquatic Toxiciology, Toxicology and Applied pharmacology and FreeChemical biology: This program is centered on cellular-methylation and DNA-repair mechanisms, biological anti-oxidation systems, environmental analytical chemistry, nano-biotechnology, and biomedical materials. Research findings have been published in distinguished journals such as Biosensors and Bioelectronics Journal of Nanomaterials Aquatic Toxiciology, Toxicology and Applied pharmacology and Free Radical Biology and Medicine. Functional genomics and proteomics: This program is concentrated on protein engineering, bioinformatics, gene regulation systems, molecular evolution, and bio- resource development. Research findings have been published in reputable journals such as theJournal of Proteome Research, Plas One, and Briefing in Bioinformatics. DBB graduate students have applied their multi-disciplinary learning and research abilities in the Center of Excellence for the Oceans (formerly Center of Excellence for Marine Bioscience and Biotechnology,CMBB), the Molecular Integrative Biology (MIB) program operated between NTOU at the Institute of Cellular and Organismic Biology at Academia Sinica in Taiwan. Therefore, the DBB is involved in the transfer of state-of-the- art biotechnology nat only for marine and aquaculture research but also for technological innovations that can lead to further insights in all of the life sciences. By participating in project-oriented and hypothesis-driven experiments, students can hone their unique abilities and prepare themselves to become leaders in the bio-industry or academia. The DBB has been awarded a research excellence fund by the Center of Excellence for the Oceans for 6 years has been actively conducting a study on environmental adaptation under the umbrella of global environmental change. The DBB will continue to provide crucial contributions in these fields to solve contemporary challenges by conducting high-level research and by teaching. Fiorinagen _Fitein Fibenagen we — i & pseu , fae S nen bines 4 ron li x TOA Aha Pee NP RAPOT TOAD AUP L + bane Schematic representation of the reversible inhibitory function of TBA15pc/TBA29pc- P8T15-antibody-conjugated geld nanoparticles (Ab-Au NPs) by using irradiation of near-UV light(a) Cad nanoparsite gy Me b) | \ \ St The schematic representation of (a) the preparation of antibody-conjugated gold nanoparticles (Ab-Au NPs), and (b) their use in the analysis of bacteria by employing laser desorption/ionization mass spectrometry (LDI-MS) Predicted protein 3D structure of BIChi4G419 using a (PS) 2 server: A. secondary structure; B. molecular surfaceZebrafish hsc70 and hsp70 expression and heat shock effect dectected by whole mount in situ hybridization. We re-discovered the biological meaning of protein-interaction networks by annotating the protein interaction motif, using the molecular function of each node in the network= . r i COO SSH RK LAE GALE HR wocwvou necovo v6 sume SGS years of services in Taiwan A tour of DBB representatives to a biotechnology corporation in Taiwan. Development Focuses Development Focuses ™ The education goals of the Department of Bioscience and Biotechnology are training "LEADERS" in the field of life sciences. The core of "LEADERs" program is Learning, with the characteristics of Efficient, Active, Devoting, Employable, and Recreating. + LStrong fundamental knowledge We paid much attention to the teaching of fundamental knowledge by offering the various course of life sciences with both broaden and deepen vision. » 2.Training professional research ability The Department requires its students to engage in research actively by conducting independent research projects at the laboratory of their choice. + 3.Fostering the independent thinking ability Besides the implement of the research projects, the students are required to engage in seminars to enhance their public speaking ability and critical thinking skills. + 4.Cultivating creativity and innovation The development of biotechnology industry depends on the creativity and innovation. We encourage students participate through structured exercises and discuss during the class. + 5.Improving the expression ability Many courses request students to have the oral presentations and reports, which could train the students to express themselves and organization ability. + 6.Preparing to face the world The English language is the second most widely spoken tongue in the world today. Our students have enough English language ability and background knowledge to face the world.Programs BS program Department of Bioscience and Biotechnology (DBB) offers a four-year program leading to the degree of the Bachelor of Science majoring in Science. The Bachelor's degree requires ¢ minimum of 128 credits and two courses of the Biotechnology, Marine biodiversity Molecular end Celluler biology, Applied Chemistry and Biology, and Bioinformatics programs Or one of above-mertioned program and one course of E-commerce, Optoelectronics and Physics Micro ond Nano Technology, Environmental Bialogy; Management, and English programs. [Sound base of knowledge] 1. Core curriculum: 28 General Chemistry (4+2), General Biology (6+2), General Physics (6+2), Calculus (6) 2. Essential curriculum: 26+2 Introduction to Computer Structure (3), Biochemistry (6+2), Organic chemistry (6+2), Biostatistics (3), Microbiology (3+1), Marine Biology (2) 3. Research curriculum: 2 Seminar (1), Special Topic Research (1) 4, General Education curriculum: 28 Chinese (6), English (6), History (2), Constitutionalism (2) MS 30 credits are required thesis: 6cr; seminar: 4cr; other requirements: 3cr; electives: 17cr PhD 30 credits are required dissertation: 12 cr, seminar: 4 cr; other requirements: 3cr; electives: 11cr Prospects Advanced Study and Career Opportunities » Advanced Study Students can choose local and overseas graduate schools of biology, life science, physiology, biomedicine, medical technology, biopharmacy, micro-immunology, molecular medicine, genetics, zoology, botany, plant pathology, entomology, parasitology, fishery, marine resources, marine biology, etc. for a Master or Ph.D. degree in western or Chinese medicine. = Career Opportunities Students are equipped to conduct research in the laboratory. Students are also trained to use all types of instruments and equipment. They will be also adept in experiment design, statistical analysis, and ecological environment evaluation and conservation. According to their interests students are free to choose career paths such as teachers, research assistants, technicians and symbolic analysts.Research Characteristics @ Our current research interests are: Studies using antioxidant enzymes to reducing oxidative damages, protection from aging. @ Proteomic analysis of DNA damage-binding proteins expressed in zebrafish (Danio rerio) embryos and unicellular alga Chlorella pyrenoidosa.Gene regulation of spontaneously expressed heat shock protein 70 in zebrafish. @Genetic regulation of fish development. Toxicity of environmental hormones in fish embryos. @ Biomolecular engineering. It includes cloning and manipulating target biomolecules on a rational base's in diverse areas of pharmaceutical, agricultural, industrial, and environmental applications. @ Metalloid speciation in marine. It includes developing analytical methods for metalloid speciations and study the metabolism of metalloids biotransformation in marine food webs. @Gene therapy. The Fas-Fas ligand (FasL) system plays an important role in the induction of lymphoid apoptosis and has been implicated in the suppression of immune responses. Our projects develop a gene therapy strategy using gene transfer of FasL on tumor cell to inhibit tumor cells growth in vivo and to make tumor regression after FasL gene transfer into cancer cells. @ Lipase engineering. The yeast Candida rugosa produces extracellular lipases(CRLs) extensively used for industrial purposes. In vitro evolution methods are performed to approach CRLs for the structure-function relationship, the enzyme reaction mechanism, and designation of novel lipase to its new applications.