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Matications Tndiation Gomments ‘Acetaminophen, NSAIDs Onl steroid (1-2 meKe) IW steroids (1-2 mg/Ke) High-dose 1V ple steroids High-dose 1V pals steroids pli mmunoeuppresion Plsmapheresis andor V immunoglobulin therapy ‘Mild as, ats Severe rash cutaneous edema, sever eaicky shdoinal pain serotal and testclar involvement Same as oral steroids, shouldbe given if patient isnot able wo tolerate ora medications Nephrot ange protciuria Rapidly progressive glomerulonephrits (RPGN), hemorrhagic involvement of | Fung, brain Refractory HSP to combination therapy (steroids and immanosuppresion) massive hemorchage in gasteointstinal or her orzans ‘These cannot prevent development of systemic invotement bat can be ell or symptomatic teatment. These decrease the Adoration of symptoms when compared 10 placebo group Same as oa steroids Decreases ESRD progression (in some case seriesand report) Grade D recommendation Grade D recommendation, but evidenceis ring wth mukipl as seris and ‘ports This usedas the ast resort to teat setactory HSP. “Taste 3 Teatment of HS, indlatons or diferent mediation: 1, 10-12) Medications indian Commer ‘Acetaminophen, NSAIDs (Onl steroid (1-2mg/K) W steroids (1-2g/Ke) High-dose 1V pe stride High-dose 1V pulse steroids ‘ls immunosappreston Pasmaphersis andor IV Jmmunoglbulin therapy ‘Mik rash, artes Severe ash cutaneous edema, severe ealicky slbdminal pain, srtal and tesialar involvement Same as ora steroids, shouldbe given if patents notableto leat oe ‘editions [Nephroti ange proteinuria Rapidly progresiveglomerulonephritis (RGN), hemorhagic involvement of fangs brain Refractory HSP to combination therapy (steroids and immunosuppression), masve bemorthage in gastrointestinal or other orsans ‘These cannot prevent development of systemic involvement bu can be lp for Symptomatic treatment. These decrease the Adration of symptoms when compared to plcebo group Same a ral steroids Decreases ESRD progression (in some case series and repors) Grade D recommendation Gade D recommendation, but evidence rowing with multiple case seis and {port This is sed a the st resort to treat tetactory HSP

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