Matications
Tndiation
Gomments
‘Acetaminophen, NSAIDs
Onl steroid (1-2 meKe)
IW steroids (1-2 mg/Ke)
High-dose 1V ple steroids
High-dose 1V pals steroids
pli mmunoeuppresion
Plsmapheresis andor V
immunoglobulin therapy
‘Mild as, ats
Severe rash cutaneous edema, sever eaicky
shdoinal pain serotal and testclar
involvement
Same as oral steroids, shouldbe given if
patient isnot able wo tolerate ora
medications
Nephrot ange protciuria
Rapidly progressive glomerulonephrits
(RPGN), hemorrhagic involvement of |
Fung, brain
Refractory HSP to combination therapy
(steroids and immanosuppresion) massive
hemorchage in gasteointstinal or her
orzans
‘These cannot prevent development of
systemic invotement bat can be ell or
symptomatic teatment. These decrease the
Adoration of symptoms when compared 10
placebo group
Same as oa steroids
Decreases ESRD progression (in some case
seriesand report)
Grade D recommendation
Grade D recommendation, but evidenceis
ring wth mukipl as seris and
‘ports This usedas the ast resort to teat
setactory HSP.
“Taste 3 Teatment of HS, indlatons or diferent mediation: 1, 10-12)
Medications
indian
Commer
‘Acetaminophen, NSAIDs
(Onl steroid (1-2mg/K)
W steroids (1-2g/Ke)
High-dose 1V pe stride
High-dose 1V pulse steroids
‘ls immunosappreston
Pasmaphersis andor IV
Jmmunoglbulin therapy
‘Mik rash, artes
Severe ash cutaneous edema, severe ealicky
slbdminal pain, srtal and tesialar
involvement
Same as ora steroids, shouldbe given if
patents notableto leat oe
‘editions
[Nephroti ange proteinuria
Rapidly progresiveglomerulonephritis
(RGN), hemorhagic involvement of
fangs brain
Refractory HSP to combination therapy
(steroids and immunosuppression), masve
bemorthage in gastrointestinal or other
orsans
‘These cannot prevent development of
systemic involvement bu can be lp for
Symptomatic treatment. These decrease the
Adration of symptoms when compared to
plcebo group
Same a ral steroids
Decreases ESRD progression (in some case
series and repors)
Grade D recommendation
Gade D recommendation, but evidence
rowing with multiple case seis and
{port This is sed a the st resort to treat
tetactory HSP