Macrophages have phagocytic properties and derive from monocytes, cells ormed in

the bone marrow.

Monocytes circulate in blood and migrate into the conectie tissue, where they
differentiate into macrophages. Macrophages have specific names in certain organs;
for example, they are called Kupffer cells in the liver, osteoclasts in bone, and
microglial cells in the central nervous system.

They produce interleukin-1 and activador of helper T cells, and tumor necrosis
factor ligand, an inflamatory mediador

Mast cells.
Like macrophages, mas cells originate in the bone marrow from myeloid precursor
cells lacking cytoplasmic granules but expresing the c-kit receptor (a tyrosine
kinase), its ligand stem cell factor and FceRI, the high affinity receptor for
immunoglobulin E.

Mature mast cells can release abundant proteases and proteoglycans stored in
granules as well as newly synthesized lipid.derived mediators (leukotrienes) after
stimulation by chemokines and cytokines.

Mast cells and basophils circulating in blood derive from the same myeloid
progenitor in the bone marrow. Basophils leave the bone marrow with cytoplasmic
granules; mast cells acquire

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