Professional Documents
Culture Documents
S1142 17-DMAG A Selective Hsp90 Inhibitor With A GI50 of 53 Nm. by Product Pathways Proteasome/HSP90/HSP70 HSP-90 17-DMAG, Hydrochloride Salt
S1142 17-DMAG A Selective Hsp90 Inhibitor With A GI50 of 53 Nm. by Product Pathways Proteasome/HSP90/HSP70 HSP-90 17-DMAG, Hydrochloride Salt
Toll Free:
S1142 17-DMAG (877)796-6397
-- USA and Canada only --
» HSP-90
Fax:
+1-713-796-9816
Technical Data:
Orders
M.Wt: 653.21 H
O
N
N
O
+1-713-922-4115
Formula: C32H48N4O8•HCl HCl
CH 3
enquiry@selleckchem.com
N
Solubility: DMSO
H
O
H 3C H
Tech Support
H 3CO
O
Purity: 99% H 3CO CH 3
H 3C tech@selleckchem.com
Storage: at -20℃ 2 years OCONH 2
(chemistry support)
CAS No.: 467214-21-7 Synonyms: Alvespimycin, KOS-1022 techbio@selleckchem.com
(bio support)
Web
Biological Activity
www.selleckchem.com
17-DMAG, a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a
selective Hsp90 inhibitor. 17-DMAG binds to the N-terminal domain ATP binding site of Hsp90,
inhibiting Hsp90 chaperone activity. 17-DMAG demonstrates greater potency and water solubility
than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG
and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral
bioavailability. [1]
Selleck Overnight Delivery Service
References
[1] Smith V et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):126-37
Return Policy
Please inspect packages immediately upon
Please visit www.selleckchem.com to download MSDS and CoA. for return if made within 3 days of delivery,
restocking charge.
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. For all product returns and product replace-