Directions for Questions 43–54.

For each numbered question select the one lettered option that is
most closely related to it. Within the group of questions each lettered option may be used once,
more than once, or not at all.
Questions 43–45 concern the following quantities:
A5L
B 12 L
C 37.5 L
D 54 L
E 60 L
Select, from A to E above, which is appropriate:

43 The apparent volume of distribution (VD) when a 450 mg intravenous dose of drug N produces an
immediate blood concentration of 7.5 micrograms/mL.

VD can be defined as: VD = D/Cp, in which D = total amount of drug in the body and Cp = plasma
concentration of drug.

44 The apparent volume of distribution (VD) when a 0.75 kg intravenous dose of drug P produces an
immediate blood concentration of 20 g/L.

45 The apparent volume of distribution (VD) when a 900 microgram intravenous dose of drug Q produces
an immediate blood concentration of 1.8 × 10–7 g/mL.