LIVER SPECIFIC PROTEIN

- These proteins are capable of assessing the behaviors of their cognate liver biological networks for
toxicity or disease perturbations.

Eight proteins (ALDH1L1, BHMT, CPS1, FAH, FBP1, GNMT, HPD, and MAT1A) were highly liver-specific,
three proteins (AGXT, COMT, DPYS) were liver-enriched. The remaining five proteins (ALDOB, ASGR1,
ASGR2, ASL, HMGCS2) were distributed in multiple organs and hence differed from their liver-specific
transcriptome profiles. For the secretory proteins, multi-organ distributions were observed. It is possible
that these abundant plasma proteins are taken up by the organs from the blood.