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Menses began to occu al regular 23-day intervals ater the fst 6 months. During the past year, menses have occurred al aregular 45-day interval. The patient's mother is concerned that her daughter may be depressed because she has become lncreasinay moody. The Patient takes no medzations. She is 163 cm (54 in tall and weighs 64 kg (142 Ib); BI is 24 kal? Examination shows striae over the abdomen, There is no eitoromegaly. The remainder of the examination shows no abnormalities. Which of the following isthe most appropriate ned step in agnosis? A) Measurement of morning serum fasting cortisol concentration B) Measurement of serum prolactin concentration C) Measurement of serum testosterone concertraton D)-CT scan ofthe abdomen ) MRI ofthe brain 22, A4-dayeold nevis brought tothe physician because ofa 2-day history of progressive jaundice, He was born at 30 weeks’ gestation to a 27-year-old woman, gravida 2, para 2 folowing an "uncomplicated pregnancy and delivery and weighed 2608 9 (5b 12 02). The newborn's bload group is 0. Rl-postive, and the mather's blood group is B, R’-poslive. He has been breast-fed since bith and receives 1 te 2 ounces ofa suoplemental soy milk-based formula every day. His mother says that he has had about seven wat clapers dally. and his stocs are yelow and seedy. At discharge 2 days 290, his ‘weight was 2495 g (5 bb 8 cz) he now weighs 2608 g (5 fb 1202), His temperature is 36.9°C (88.4°F), pulse is 138!min, respirations are 32imin, and blood pressure is 05/40 mm Hg, Examination shows soleralcterus and jeunlice from the face tothe lower abdomen. The Iver edge is palpated 2 cm below the right costal margin. Laboratory studes at 36 hours of age and new show AL 36 Hours of Age Now Hematocrit (%) 84 52 Serum Bini, total (mg/d) 82 125 Deect (mgidL) on 03 Which ofthe folowing i the mest likely explanation for these ndings? |A) ABO iscbmmunizaton B) Bilary obstruction (6) Detyaration| s D) Enjtivocyte ereyme defect ) Physiologic jaundice F) Polyeytheria 25. A.4-yearold gil is admitted to the hospital because of a G-hou history of fever, decreased alertness, ancl arash over her chest, ams, and legs. On admission, the patent is obtunded, Her temperature is 88°C (100.4'F), pulse is 120/min, respirations are 80Vmnin anc sallow, anc blood pressure is 70/80 mm Hg. Examination shows a purple macular rash over the tk and extremities. Te face and extremities are edematous. Flies administered by intravenous bols, and rtravencus administration of cetriaxcne and vancomyein is started, Fiteen minutes after acmission, the patient becomes apnelc. She ls intubated, and mechanical ventlationis started, Serum studies shove Na 135 mEgL & 4 meqiL Heo, 15 meqit Ureantrogen 35 maid Creatine 0.8 grat Her urine output is 1.5 mUkgih Arterial blood gas analysis on 40% oxygen shows pH 72 Peo, 35 mm Hg Pao: 100 mm Hg ‘One hour later, her wine out decreases to less than 0.5 mLikalh. A chest ray shows hazy ung elds bilaterally and earciomegaly. Which ofthe following isthe most appropriate next step in ‘maragement? A Intravenous administration ofan isotonie fd bolus B} Intravenous administration of dopamine © Intravenous administration of furosemide D} Intravenous adrnistration of nitroprusside E) Increased inhaled oxygen concentration ‘A 12-montold gi is brought tothe plysican because of chickenoox for 4 weeks, She developed vesicular lesions on her heady, turk, and extremities 2 weeks after her okler brother developed lesions, and she has continued to ave new lesions since then. She is atthe 10th percentile for length, weight, an head circumference. Her temperature is 28°C (100.4°F). Examination shows papules, Mid-ited ‘esicles, ane crusted small cers scattered over the head, trunk, and proximal extrerites, Indvect fuorescent antibody testing of the material ram te bate of one ofthe vesicles le postive fr the varicella artigen, Which ofthe folowing isthe most Skely immunologic abnormality? A Impaired B-bmphocyte function B) Impaired complement function Impaired neutrophil adhesion D) Impaired nevtrophil chemotaxis E) impaired T-lymphocyte function F) Neueropél oxaton burst 38, A S-menth-old boy is broug to the physician by his mather because of a T-day history of fever, voting, and fussiness. He was born at 29 weeks’ gestation following an uncomplicated pregnancy and elvery. He is alert and mildy Writable bit easly consoled by his mother. His rectal temperature is 38°C (102.2°F), pulse is 18D/min. and respirations are 38/min. Examination of the skin shows no abnormalties. The tympantc membranes are mild erythematous with nermal landmarks and metity. The ngs are clear to auscutation. Tae abdomen is soft with no palpable masses. The patent I Unereumeised, Laboratory studies show: Hemoglobin 11.8 gtd Leukocyte count 12,200rmm® Platelet count 240.0004 Urine Nites 2 Leukocyte esterase 3+ Resuits of blood and urine cutures are pening. Wrich ofthe folowing isthe most appropriate pharmacotherapy? 8) Cefazolin B) Cefotaxdme (C)Natetin D) Peniciin E) Vancomycin

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