Data Pengamatan

Konversi Ke mencit murni

600mg x 0,0026 = 1,56mg/20g mencit

500mg x 0,0026 = 1,3mg/20g mencit

400mg x 0,0026 = 1,04mg/20g mencit

300mg x 0,0026 = 0,78mg/20g mencit

563,3 mg bobot rata-rata tablet mengandung 500mg parasetamol

563,3 / 500 x 1,56 = 1,75mg/0,2 ml

563,3 / 500 x 1.3 = 1,46 mg/ 0,2 ml

563,3 / 500 x 1,04 = 1,17mg/0,2 ml

563,3 / 500 x 0,78 = 0,87mg/0,2 ml

Perhitungan pengenceran

 V1 . N1 = V2 . N2

V1 . 1,56 mg/0,2ml = 5ml . 1,3mg/0,2ml

V1 x 7,8 mg/ml = 5ml x 6,5 mg/ml

V1 = 32,5 / 7,8 = 4,17 ml (larutan stok ad 5ml)

 V1 . N1 = V2 . N2
V1 . 1,56mg/0,2ml = 5ml . 1,04mg/0,2ml
V1 . 7,8mg/ml = 5ml x 5,2mg/ml
V1 = 26 / 7,8 = 3,33 ml (ad 5 ml)

 V1 . N1 = V2 . N2
V1 . 1,56mg/0,2ml = 5ml . 0,78mg/0,2ml
V1 . 7,8mg/ml = 5ml x 3,9mg/ml
V1 = 19,5 / 7,8 = 2,5ml (ad 5 ml)
 Berat badan mencit 1 = 30, 98 g
Berat badan mencit 2 = 35, 89 g
 30,98g / 20g x 0,2ml = 0,31 ml
 35,89g / 20g x 0,2ml = 0,36 ml

No Pengujian Sediaan Berat badan Hasil geliat Jumlah Rata2

Mencit Mencit 2 5’ 10’ 15’
1
1 Kontrol (-) PGA 1% 34,37 42,26 22 24 30 76 25

2 Kontrol (+) PCT 600mg 34,94 40,35 12 5 34 51 17

3 Dosis I PCT 500mg 26,56 36,29 - 20 23 43 21
4 Dosis II PCT 400mg 36,65 20,35 9 13 15 37 12
5 Dosis III PCT 300mg 30,23 34,49 - - 21 21 21

% proteksi analgetik = 100 – [rata – rata jml geliat kel uji] x 100%
Rata-rata jml kel (-)
= 100 – [12 / 25] x 100%
= 100 – [0,48] x 100%
= 100 – 48
= 52%

% efektivitas analgetik = [% proteksi kel uji] x 100%

% proteksi asetosal
= [ 52% / ] x 100%