CELLULAR SOURCES OF PAF AND RELATED LipIDs 199 Table 7.1 Cellular sources of PAF and acylPAF* Cou ‘Stimulus? Released Reference Calls synthesizing predominantly alkyl-linked PAF species Neutrophil 23187 + Betz and Henson (1980) 49% JJouvin-Marche et al (1984) 10-20% Lynch and Henson (1986) 110% ‘Sisson et al. 1987 23187 + cyto B + Oda et al. (1985) Opsonized zymosan + Betz and Henson (1980) + Lotner ot a. (1980) 26% Lynch and Henson (1986) 110% ‘Sisson etal. (1987) Zymosan + ‘Sanchez Crespo et al. (1980) FMUP 110% Sisson et al. (1987) FMLP + cyto 8 + Betz and Henson (1980) 33% Lynch and Henson (1986) 30-40% Ludwig of al. (1984) 30-40% Ludwig et a. (1985) cou + Bete aint Henson (1960) + Camussi et al. (1981a) Ca des arg + Camussi et a, (19814) Aggregated IgG + Betz and Henson (1980) + ‘Sanchez Crespo etal. (1980) Immune complexes + ‘Sanchez Crespo etal. (1980) + Camussi et al. (198ta) Neutrophil cationic protein + Camussi etal. (19814) Neutrophil cationic protein des arg + Camussi ot af, (19814) Chymotrypsin + Camussi ot a, (1988) Elastase + Camussi et al. (1988) Cathepsin G + Camussi ot al. (1988) Complement-activated baker's yeast + Camussi of af. (19814) spores IgG + C3 coated RBC + Betz and Henson (1980) pH 10.6 + Camussi ot af, (19814) NaF + Betz and Henson (1980) PMA + Betz and Henson (1980) + Nieto ot a. (1988) LPs = Worthen ef al. (1988) wt + Camussi et al. (1988) TNE + Camussi ot al. (1988) CarbamylPAF NA Tessner et al. (1989) PAF NA Doebber and Wu (1987) GM-CSF - Stewart of al. (1991) Eosinophil 823187 + Lee et al. (1984) 10% Burke et al. (1990) 35% Cromwell etal. (1990) NA Trigglani et al. (1991c) FMLP + Lee of af. (1984) NA Triggiani et al. (1991) ECFA + Lee of al. (1984) 5a + Lee ot a. (1984) \gGSepharose beads 40-55% Cromwell etal. (1990) Unopsonized zymosan 9% Burke etal. (1980) Monocyte 823187 + Sanchez Crespo etal. (1980) + Camussi et al (19814) + ‘Arnoux et al. (1982) 37% 70% late alone and Epstein (1988) ENS Valone and Epstein (1988) PAE NA Valone (1991) Alveolar macrophage 423187 + ‘Arnoux of al. (1980) + Arnoux et al. (1987) Anit-IgE + Arnoux et al. (1887) Specific antigen + Arnoux et al. (1887) Opsonized zymosan NA Triggiani etal. (199%) Monoeyle-derived macrophage 23187 + Elstad et al. (1988) PMA + Elstad et af. (1988) Opsonized zymosan + Eistad ot al. (1988) Cells that synthesize predominantly acyl-PAF Endothetial col! 23187 + Camussi et a. (19830) NA Triggiani etal. (199%) ‘Angiotensin I + Camussi et al (19830) Anti-human factor Vil + Camussi et a. (1983) a 25% Bussotino ot a. (1986) 30% Bussolino et al. (1986) LTC, and LID, 2-3% Meintyre et al. (1986) Thrombin NA Prescott ef al. (1984) NA Triggiani etal. (1991) Mcintyre et al. (1985) H.02 Lewis etal. (1988) NA Whatley ef al. (1988) Clostridial 6 toxin NA Whatley etal. (1988) Melitin NA Whatley ef al. (1988) Membrane attack complex of NA Whatley ef al. (1988) complement Vasopressin + ‘Camussi et al. (1983b) Histamine Melntyre et af. (1985) Bradykinin - Melntyre et al. (1985) ATP Meintyre et af. (1985) TNE + Camussi ot a. (1987) 30% Bussolino et al. (1988) LPs 45% Lynch and Henson (1986) Elastase + Camussi et a. (1988) Mast cell (pulmonary) Ant-IgE 7 Lichtenstein et al. (1984) Schleimer et al. (1986)(CELLULAR SOURCES OF PAF AND RELATED Lipps 201 Table 7.1 Continued Celt Stimulus? Released® Reference NA Trigglani et al. (1991¢) 823187 NA Triggiani et af. (1991¢) Basophil® 23187 + Camussi et al. (19814) NA Triggiani et af. (1991¢) ‘Synacthen + Camussi et al, (19814) Complement-coated baker's yeast. + Camussi et af. (19814) spores 3a + Camussi et al. (1977) Sa + Camussi et al. (19814) Neutrophil cationic protein + Camussi et al. (1977) + Camussi et al. (19814) DNAt + Camussi et al. (1981b) Anti-IgE + Camussi et af. (19814) NA Trigglani et al. (1991c) pH 106 + Camussi et af. (19814) Cells for which PAF synthesis is attributed, but linkage predominance is unknown Platelet Thrombin NA Touqui et al. (1985) NA ‘Alam and Sitver (1987) 23187 NA Chignard et al. (1979) NA Alam et al. (1983p) Large granular lymphocytes Immobilized anti-Fe receptor + Malavasi et al. (1986) (NK cals) 23187 + Malavasi et al. (1986) Fibroblasts (human skin) A23187 50% Michel et ai. (1988) Transformed or neoplastic cells HL-60 Neutrophitike? 23187 NA Billah ef al (1988) FMLP NA Billah et al. (1986) Macrophage-ke” pH 9S + Camussi et a, (1982) (Cab-baker’s yeast spores + ‘Camussi et al. (1982) C3d-baker's yeast spores + Camussi et al. (1982) usa7" Macrophage-ike RSV + Villani et al. (1991) Basophilic leukaemia 23167 + Lewis et al. (1975) T-cell ALL 23187 + acetyl-CoA + PHA + Foa et al, (1985) ‘Common ALL A23187 + acetyl-CoA + PHA + Foa et al, (1985) CLL (B cot) 23187 + acetyl-CoA + PHA + Foa et al. (1985) ML 23187 + acetyl-CoA + PHA + Foa et al. (1985) AML 23187 + acetyl-CoA + PHA + Foa et al (1985) T cell leukaemia coll nas ‘A23187 + acely!-CoA + PHA + Bussolino et al. (1984) 8 cell leukaemia cell ines 23187 + acetyl-CoA + PHA + Bussolino et al. (1984) EBV transformed lymphoblastoid cell A23187 + acetyCoA + PHA + Bussolino et al. (1984) lines * Table adapted from Bratton and Henson (1969) ® Apbceviations: A23187, calcium ionophore; cyto B, cytochalasin B;carbamyl-PAF, 1-O-alky-2.N-methyicarbamyi-sn-glycero-3-phosphacholine; SY. respiratory syncytial virus © PAF released: +, detectable PAF release; ~, no detectable PAF release; NA, PAF synthesized but release not assessed. * Cols from atopic asthmatics or following passive sensitization of calls from normal patients * Basophitenriched leucocyte preparations. * In cels trom patients with systemic lupus erythematosus. * Ditferentiated towards neutrophil-ike cells with DMSO. "Differentiated towards macrophage-like cells with tetradodecanoyiphorbol acetate (TPA) * Human histiocytic lymphoma cel line differentiated towards macrophage-ike cells with PMA. agonist (T-c. Lee et al., 1984; Ludwig et al., 1986; “phase of response” (Valone and Epstein, 1988), pH Lynch and Henson, 1986; Elstad et al., 1988), priming of the medium (Leyravaud and Benveniste, 1989) and (Stewart et al, 1991), state of adherence versus presence of antiproteinases (Camussi ct al., 1988). suspension (Sisson et al., 1987; Elstad et al., 1988), Demonstration that this is also affected by cell density