Dy Pen Ting, Marc Denver O. Dr.

Vincent Thomas Alferos

2B-MT 03/23/2018

Nanotechnology Based Approaches for Enhancing Oral

Bioavailability of Poorly Water Soluble Antihypertensive
Drug
Oral administration of drugs is by far the most convenient and least invasive way
of administering drugs. One contributory factor to the efficacy of these drugs is
their ability to be dissolved in water, thus becoming more available for utilization
by the body. This journal discusses the viability of nanotechnology based
approaches to enhance the oral bioavailability of these hydrophobic and lipophilic
new chemical entities. The bioavailability of these poorly soluble substances are
enhanced with the use of Nano emulsions, dendrimers, micelles, liposomes, solid
lipid nanoparticles, polymeric nanoparticles, and carbon nanotubes, which
facilitate, sustain and target the drug delivery within the body. However, as with
any other emerging medical prospect, it is not without challenges. Some of those
encountered are the transformation of the nanocarrier systems to serve a
nationwide, or even worldwide market, the cost and reproducibility of the
product and the benefit that it may bring about, taking into consideration the
varying effects that it may have on different people. In conclusion,
nanotechnology is opening an avenue for scientists to further their studies
regarding the currently available as well as emerging antihypertensive drugs with
improved patient compliance and therapeutic efficacy.

Reference:

Mayank Sharma, Rajesh Sharma, and Dinesh Kumar Jain, “Nanotechnology Based
Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble
Antihypertensive Drugs,” Scientifica, vol. 2016, Article ID 8525679, 11 pages, 2016.
doi:10.1155/2016/8525679

http://dx.doi.org/10.1155/2016/8525679