PATIENT: BED: WARD:

DOSE: FREQUENCY: TIME: OTHERS:

CEFIXIME
PHARMACOLOGIC CLASS: Third- generation cephalosporin
THERAPEUTIC CLASS: anti- infective
DRUG ACTION: Interferes with bacterial cell- wall synthesis and division by binding to the cell wall, causing cell to die. Active against
gram- negative and gram- positive bacteria, with expanded activity against gram- negative bacteria. Exhibits minimal immunosuppressant
activity.
INDICATIONS: uncomplicated gonorrhea, uncomplicated UTI
CONTRAINDICATIONS: hypersensitivity to cephalosporins or penicillins

ADVERSE EFFECTS:

CNS: headache, lethargy, paresthesia, sncope, seizures

CV: hypotension, palpitations, chest pain, vasodilation
EENT: hearing loss
GI: nausea, vomiting, diarrhea, abdominal cramps, oral candidiasis, pseudomembranous colitis
GU: vaginal candidiasis, nephrotoxicity
Hematologic: lymphocytosis, eosinophilia, bleeding tendency, haemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia,
agranulocytosis, bone marrow depression
Hepatic: hepatic failure, hepatomegaly
Musculoskeletal: arthalgia
Respiratory: dyspnea
Skin: urticaria, maculopapular or erythematous rash
Other: chills, fever, superinfection, anaphylaxis, serum sickness
NURSING RESPONSIBILITIES:

MONITORING:
● Monitor baseline CBC and kidney and liver function tests.
● Monitor for signs and symptoms of superinfection and other serious adverse reactions.
● Be aware that cross- sensitivity to penicillins may occur.
TEACHING:
● Tell patient to take once- daily doses at same time each day.
● Advise patient to take drug exactly as prescribed and to continue to take full amount prescribed even when he feels better.
● Instruct patient to report signs and symptoms of allergic response and other reactions such as rash, easy bruising, bleeding, severe
GI upset or difficulty breathing.