Video Table of Contents, x Contributors, xii Video Contributors, xxv Dedication, xxvii Preface, xxix VOLUME ONE PART 1 Retinal Imaging and Diagnostics aia by SeiniVasR. Sada © 1 Auorescein Angiography: Basic Principles and Interpretation, 1 Sara Haug, Artur D. Fu, Robert N, Kans H. Richard NeDoval J. Nichaet Dumper Emmett Cunningham Mt ‘Bandon I. Lyon 2. Clinical Applications of Diagnostic Indocyanine Green Angiography, 46 CGionaant Satreng, Fealmando Hote, andra Gat © 5 Optical Coherence Tomography, 77 [auia K Maho, Ami iH, Kashet Crk Alsen de Ameri Gacs Filto, lay S. Dake, Pip Resend 4 Autofluorescence Imaging, 120 ‘Nonita Flckerstin, Sif SchiteNalonberg, Fak. Hole Wide-Field Imaging, 143 ‘Mics! A Kui, Sand Ks © 6 Intraoperative Optical Coherence Tomography Imaging, 167 Insts. Eers Cyia A. Tah 7 Advanced Imaging Technologies, 176 Pare A. Keane SriniVasR.Sadit ° 8 Image Processing, 196 Nihal D. Ano 9) Hlectrogenesis of the Electroretinogram, 224 aura, sna 10 Clinical Electrophysiology, 249 Sco Mil, Kei Shinada © 11 Diagnostic Ophthalmic Ultrasound, 273 Rl} E.Guthef, Lanne T:Labril, Oliver Stacks 12. Color Vision and Night Vision, 325 ingest Cio 43. Visual Acuity and Contrast Sensitivity, 340 Gary. Rabon 14. Visual Fields in Retinal Disease, 348 ajo S. Ramchandra, Amit A, Sargave, Steen F, Felon PART 2 Basic Science and Translation to Therapy td by David 8. Hinton SECTION 1 Anatomy and Physiology 15 The Development of the Retina, 375 Thomas A Reb 1G Structure and Function of Rod and Cone Photoreceptors, 387 Teumie Che: Aap P Sampath 17 Function and Anatomy of the Mammalian = @ Retina, 408 Ronald G. Gre, Jos Singer, Maarten Kamerun Maireen A. NECA, Sepher © Masey 18 Cell Biology of the Retinal Pigment Epithelium, 451 lames T Handa 19 Cell Biology of Retinal Glia, 466 Andis Reichenbach, Andras Beingmaon 20, Retinal and Choroidal Vasculature: Retinal Oxygenation, 488 Mar B. Gran, Gerard A, Laty 21 Mechanisms of Normal Retinal Adhesion, 504 Mile EMarmer 22 Structure, Function, and Pathology of Bruch’s Membrane, 522 Chrtine A, Cac, Merk onsen 23. Vitreous and Vitreoretinal Interface, 544 1 Seiug SECTION 2 Basic Mechanisms of Injury inthe Retina 24 Mechanisms of Oxidative Stress in Retinal Injury, 582 Milam A. Beate ie Alison C: Une, Pau Stemi 25. Mechanisms of Endoplasmic Reticulum Stress in Retinal Disease, 596 Spe B. Sin Copyrighted Materialvi Contents 26 Cell Death, Apoptosis, and Autophagy in Retinal Injury, 605 ‘MidhaelE, Boulton, SialeK. Mites 8. Louie Pay 27 Inflammation and Immune Responses in Retinal Health and Disease, 625 “Andrew. Dick, Richard Wo Role B, Nusenblat (poshunvust) 28 Basic Mechanisms of Pathologic Retinal and Choroidal Angiogenesis, 638 Demetris. Vata ASDMENS Thao, AV: Pte sas W. Miler 29 Blood Retinal Bai Autoimmunity, 656 Kar R Are Raber 8, Nussenbat (pthc) 30. Mechanisms of Macular Edema and ‘Therapeutic Approaches, 067 Anaya M. loss, Alan Sit Noe Lois 31 Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium, 689 Lovisa Wictam, Geafrey Lewis David G Charters Steve f Fer 32. Serous and Hemorthagic Detachment ‘of the Sensory Retina and Pigment Epithelium, 703 ise Soubrane asic, Gabi Cscas SECTIONS Genetics 33. Genetic Mechanisms of Retinal Disease, 71 ‘Stephon P.Daigt Lov 8. Sulan, Sara. Rowe 34. Mitochondrial Genetics of Retinal Disease, 722 M, Crisina Keney Debouh A Feng Nin dar 35. Epigenetic Mechanisms of Retinal Disease, 733 ‘Shino He Rees Koutrs SECTION 4 Translational Basic Science GL 36 Gene Therapy for Retinal Disease, 744 Jean Beanet, Allert Mt. Maguire © 37 Stem Cells and Cellular Therapy, 763 Ted | Rovland, Morin Friedlander, Dad R, Hine, arid M. Comm Downs 0, Ces 38 Nanomedicine in Ophthalmology, 780 ‘Marco . Zebin James F. Leary, Carlo Montemagro, Roler itch, Mark S. Humayun 39 Neuroprotection, 811 Beredeno Fas, Roald A Bish, Paul A. Sex, 40 Drug Delivery, 831 rin B Lavi Rauch D. Ruppermern, Mark, Humayun 41 Retinal Laser Therapy: Biophysical Ba: Applications, 844 ‘Daniel Palarker Mart S. Bumenteane and ier, Immune Privilege, and Copyrighted Mate VOLUME TWO Medical Retina Edie By Andrew P.Scachat and SriniVes R Sadat SECTION 1 Retinal Degenerations and Dystrophies a 43, 45 46 Retinitis Pigmentosa and Allied Disorders, "861 Kevin Gregory -ouns Ricard G, Welter, NareE, Pees Hereditary Vitreoretinal Degenerations, 936 Sho Tang Xap Dig Yas Ly Macular Dystrophies, 953 Foe H. So, Raber Mui Ean M Ste Hereditary Choroidal Diseases, 997 Sandeep Goer Gerd A Fstman Abnormalities of Rod and Cone Function, 1006 AagelaN. Badin, Anthony G. Reson, Anthony Moo, Jacque, Duncan SECTION 2 Retinal Vascular Disease a7 48 49 50 52 53. 54 35 36 37 8 59 ‘Ihe Epidemiology of Diabetic Retinopathy, 1018 Ronald Klen, Burbera EK. Kin Diabetic Retinopathy: Genetics and Etiolos Mechanisms, 1038 [Nicest M. Hodgion Je iu Frances Wu, Hey A. Borer, Kang Zhang Diabetes Mellitus, 1055 Mari Sgr Nonproliferative Diabetic Retinopathy and Diabetic Macular Edema, 1061 Henry, Wile Emi ¥. Che Praderck Fes Proliferative Diabetic Retinopathy, 1091 Fear K. Sun, Pal S. Sie, lemy D. Catalenna, Barbara A. Bl, Matthew D, Das, op. sill bp Pal atte Hypertension, 1122 Carol Yat Gung, Ti ¥ Wong yetic Retinopathy, 1129 ‘Telescreening for Rajiv aman, Tarun Sharma Retinal Artery Occlusions, 1136 Paris S. Patel, SriniVs R Sad Acquired Retinal Macroaneurysms, 1151 Ely Cle abet P Murphy Branch Retinal Vein Occlusion, 155 Angela Beste, Pet K. Kater Central Retinal Vein Occlusion, 1166 Patrick Osler Pal Hal, Sara Bola Macular Telangiectasia, 1180 Enily¥ Che, Lauence A anmszi Coats Disease, 1188 [Nikola JS London, Carl, Shields, lia 8. Haller Copyrighted MaterialCopyrighted Mate 60 Hemoglobinopathics, 1203 Adrienne W. Sent, Mort F Goldberg Gea 8. Lary 61 Radiation Retinopathy, 1219 Leigh Spl, Pati De Pater Ania Les © 62 Ocular ischemic Syndrome, 1227 Gary C. Brown, Sanjay Sharma, Melisa M Braun 63 Coagulopathies, 1240 Sens Lopes, Flan M.A, Heusen, SrinvisR, Suda © 64 Pediatric Retinal Vascular Diseases, 1246 Thomas C: Lee, Mick tel F Chong 65. Telesereening for Retinopathy of Prematurity, 1268 Michael F Chiang SECTION 3 Choroidal Vascular/Bruch's Membrane Disease 66 -miology and Risk Factors for ‘Age-Related Macular Degeneration, 1273 Jana Seddon, Luca erin: Dug 8. Bonar 67, Pathogenetic Mechanisms in Early Age-Related Macular Degeneration, 1285 an Bind 68 Age-Related Macular Degeneration: Non- Neovascular Early AMD, Intermediate AMD, and Geographic Atrophy, 1293, ‘Alam S. Wei, Nei M, Bre Suan Broster 69 Neovascular (Exudative or "Wet") Age Related Macular Degeneration, 1345 Gripe. Brady Nel M.Bresler Susan 8. Bresler 70. Pharmacotherapy of Age-Related Macular Degeneration, 1373 [ieShan B Leung Maro A. Zbin, Philp) Rosen ‘ian iy Dal Mant, Mark. Basie 71 Pathologic Myopia, 1423 Avot Oats, Tato sibs 72 Angioid Streaks, 1438 ‘ond. tam 73. Ocular Histoplasmosis, 1446 Joi Cher Anew B Schacht 74. Polypoidal Choroidal Vasculopathy, 1458 Xiaonin Li 75. Ceniral Serous Chorioretinopathy, 1465 ‘enmi Lan, Sudipts Dus lily Li Viet Loe Lin a 76 Uveal Eifusion Syndrome and Hypotony Maculopathy, 1484 (Gag Ges. Mac V folason SECTION 4 Inflammatory Disease/Uveitis Inflammation 77. Sympathetic Ophthalmia, 1496 ‘anil Vier Vaconclos Samus, Narsing A Rao Contents vil 78. Vogt-Koyanagi-Harada ira Goto, P. Kamar Raa, Narsing A. Rao 79. White Spot Syndromes and Related Diseases, 1516 ukhsana . Mirza, Lee Mt, Jampot 80 Autoimmune Retinopathies, 1562 Austin RFs HL, Nd Son, Robot. Nusentat (podiums) 81 Sarcoidosis, 1572 Ys Jamal Seah Ama Agarwal, Dogs A, tabs Quan Dang Neiqen 82 Intermediate Uveitis, 1586 Phodie Lin, enn). lafe 83 Rheumatic Disease, 1597 Alsi Dennison, enjumin Res, Mary Gap David Caruthers, Carine Gordan, Philip. Murrey Infections 84 HIV-Associated Infections, 1624 Igor Koza, J. Allen McCutchan, Wiliam R. Feeman 85 Mycobacterial Infections, 1657 Shwumar R.Rahinam, Perumalsamy Nemperumalsany 86 Eales Disease, 1664 Dhananjy Shukla Perumalsamy Namperumalsamy 87 Spirochetal Infections, 1672 fale. Ba, Nasng 4, Ray 88 Ocular Toxoplasmosis, 1081 ubons Blot fr, lati Sve, Cristina Macca 89 Helminthic Disease, 1685 Manas Ala, David ae 90. Endogenous Endophthalmitis: Bacterial and Fungal, 1700 ‘ay, Karn, Sephen G. Scher fanett. Das Harry W. Fn 91 Acute Retinal Necrosis Syndrome, 1709 G. Ama VenulakraJyS.Pase, Ruse N. Va Gelder SECTION 5 Miscellaneous 92. Drug Toxicity of the Posterior Segment, 1719 MifuelT, Andreok, Reber A. Mitta, Willan F Mieer 93. Photic Retinal Injuries: Mechanisms, Hazards, and Prevention, 1746 Andie Symons Helen Char, Martin A. Mairster 94 Traumatic Chorioretinopathies, 1757 Dear Blt, Tans D. Palos 95. Pregnancy-Related Diseases, 1771 Sid Shecet, Jane. Sure 96 Optic Dise Anomalies, Drusen, Pits, and Associated Retinal Pathology, 1786 Rustam Karan, 5. Kor, Khadr, Afods A, Sadan 97. Retina Related Clinical Trials: A Resource Bibliography, 1796 Barbara S. Haulns, Usha Chalswoathy Copyrighted Materialviii Cortents VOLUME THREE PART 1 Surgical Retina lity € 0: Witkinon and Peter Wederann SECTION 1 The Pathophysiology of Retinal Detachment and Associated Problems 98. Pathogenetic Mechanisms of Retinal Detachment, 1821 Shustion Wf, Martin Ziskeragel © 9 Nonrhegmatogenous Retinal Detachment, 1828 Poring eh, Ching May ing. Chang Hao Song ang ing in 100. Degenerative Retinoschisis, 1850 Da Bt Si) Cog 101 Pathogenesis of Proliferative Vitreoretinopathy, 1856 Petr Wiedemann, Yrs ones, -ianHu 102 Pathophysiology of Ocular Trauma, 1865 Sun Young ne SECTION2 Retinal Reattachment: Generel Surgical Principles and Techniques 103 The Biomechanics of Scleral Buckles in the ‘Treatment of Retinal Detachment, 1875 John. Thompson GIO 104 techniques of Sceral Buckling, 1859 Pa Ste 105. Principles and Techniques of Vitreoretinal Surgery, 1516 Siow Cates Gi 106 Primary Vitrectomy in Rhegmatogenous Retinal Detachment, 1953, Yong Hor Yan, Shue She, Hiroe Tra 107 Pneumatic Retinopexy, 1943 Dasiel A Brinton, Alen Chiang 108. Special Adjuncts to Treatment, 1957 Tan. Wong, arid Vig G1 109 Optimal Procedures for Retinal Detachment Repair, 2007 Lond Wick, GWE Ad M0 Prevention of Retinal Detachment, 2017 CH Waking SECTION 3 Complicated Forms of Retinal Detachment Gi Protiterauve vireoretnopathy, 2031 Ton Ce Sah gd 12 Retinotomies and Retinectomies, 2052 Gary W. Abrams, Enrique Garcia Valenzuela, Sumit K Nanda Giant Retinal Tear, 2072 Lingam Gapl, Tarun Sharma, Pama S Bho, Misa Bhende m3 Copyrighted Mate 114 Surgery for Ocular Trauma: Prine Techniques of Treatment. 2081 PuncoM.Rechi, Paul Sternberg 115 Surgery for Proliferative Diabetic eo Retinopathy, 2107 Sino Bruner Susan Binder 116 Management of Combined Inflammatory and Rhegmatogenouss Retinal Detachment, 2135 ‘Mare. de Sine, Kernan 117 High Myopia and the Vitreoretinal Complications, 2146 ssh Ho, Masato Ohi M8 Surgical Management of Retinopathy of Prematurity, 2155 Yio Yel, Lisa. Fl, Mice Tse 119 Surgery for Pediatric Vitreoretinal orders, 2470 Para Meie. Peer Wiedenan SECTION 4 Vitreous Surgery for Macular Disorders: 120 Epiretinal Membranes, Vitreoretinal Traction, and Cystoid Macular Edema, 2194 Lesa Wideham, Lazaros Konstan, Thomas J Wolfwbaer 121 Macular Hole, 2213 Alun Gaui, Ramin Tatas 122. Surgical Management of Choroidal Neovaseularization and Subretinal Hemorthage, 2233 Enchut M Lite Mathew W.Achienner, Mathew A. Thomas 123 360-Degree Macular Translocation, 2240 Fists hie Cyt Toh 124 Retinal Pigment Epithelium and Choroid. ‘Translocation in Patients with Age-Related Macular Degeneration, 2254 JC. var Mews, Bera Kieth, Rost NacLanen on SECTION 5 Vitreous Surgery: Additional Considerations 125 Infectious Endophthalmitis, 2266 Thuis A. Meredith | Niklas Uc 126 Diagnostic and Therapeutic Vitrectomy for Uveitis, 2287 Heong Gi Yi Tae Win Kine 127 Vitreous, Retinal, and Choroidal Biopsy, 2296 Willan R. Rhoades, Andrew |. Baldwis, Quan Dong Neuve, Dana. bo 128 Transplantation Frontiers, 2309 Venat Gull, Molumal A Khai Ant M. Kole, ewe K Sugino, lew Nadie, aro 8. Zarb 129 Artificial Vision, 2340 ‘ar SHunayan, Hosen Nizar anes Welland Copyrighted MaterialOm Copyrighted Mate 130. Pharmacologic Agents and Vitreoretinal Surgery, 2358 (Onis Hart, Anse Kamp €5131 Complications in Vitreoretinal Surgery, 2368 Kouroas A. Reziei PART 2 Tumors of the Retina, Choroid, ac ty ani Schacht ind Vitreous SECTION 1 Tumors of the Retina 132 Retinoblastoma, 2375 Jonathan W. Kim, Naney C. Mansa (postunoush, ALi sturpice 133 Cavernous Hemangioma, 2421 Anita Agar Paul Stomberg 134. Hemangioblastoma of the Retina and Von Hippel-Lindau Disease, 2427 ‘Henny Wiley Andrew. Schackat Emily ¥. Chew ‘Tuberous Sclerosis and the Eye, 2438 Aan Cres, Sanjay Sarna Phakomatoses, 2446 Gul Shield, Jery A. Sheds Retinal Metastases, 2461 Sani Sr, Chis Ron Remote Effects of Cancer on the Retina, Ranft S. Dhliv, Andew P Schacht ‘Melanocytoma of the Optic Disc, Gra Shields Lena oe leny A. Shs Congenital Hypertrophy of the Retinal Pigment Epithelium, 2490 Caro H, Meyer, Roti Gerding 135 136 137 138 27a 139 2484 140 141 Combined Hamartoma of the Retinal Pigment Epithelium and Retina, 2495 Dilly A. Qua, Antonis Capone SECTION 2 Tumors of the Choroid Choroidal Nevi, 2502 Geristphe KH. Baris, Daniel Mt. Albert 143 Ppidemiology of Posterior Uveal Melanoma, 2515 Jolunaa Ne Seldon, Tare A. MeCamnd Prognosis of Posterior Uveal Melanoma, Johansa 8 Seddon, Tara A, MeCamnl 144 2523 145. Molecular Genetics of Choroidal Melanoma, 2533 ‘Ait Sathi .SioioGulnd Contents ik 146 Pathology of Choroidal Melanoma, Marina. Herwig Carl Hans B, Gsnilaw 2540 147. Overview of Management of Posterior Uveal Melanoma, 2555 Carol Shield, Jey , Shields 148 Enucleation for Choroidal Melanomas, Iain D. Perm, Anos D. Singh, Rao V. Chany Brachytherapy for Choroidal Melanoma, 2560 1H. Cul Boldt. Stud K: Howton, Amal M. Marko, Timathy G. Saray Charged-Particle Irradiation of Uveal Melanoma, 2582 rangle S. Ginga Ani MariLan, oe K. Kin Surgical Resection of Cho: Melanoma, 2591 Sere? E, Damato jay Ml. Sear, Armin & Afar Carl Groeewsld, WallceS. Foulds 2561 149 150 15 152. Laser Treatment of Choroidal Melanoma, 2601 Nortert Bord Systemic Evaluation and Management of Patients with Metastatic Uveal Melanoma, 2608 Avni C Darl, Paul Pinger 153 154 Collaborative Ocular Melanoma Study, 2613, Barbra 8. Haulin, Andrew P. Schacht Choroidal Metastases, 2621 Kristin, Reinond, Mendy D. Wharem Je Andree P Schachat Choroidal Osteoma, 2628 (Ca L. Shields Gary CBs, Sanjay Sharma, Jey A Stes 2638 155 156 157 Circumscribed Choroidal Hemangioma, Mae L Setter, Shey Day Pace narathynaya SECTION 3 Hematologic and Miscellaneous Tumors 158. Miscellaneous Uveal Tumors, Alison Shalt, Dard Wilson 159 Leukemias and Lymphomas, 2660 ura ¥ Do, Rani. Dhl Andrew Schacht 160 Primary Vitreoretinal Lymphoma, 2675 Mary B, Aroma Andraw PSchichat David M.Poreboom, Arun D. Singh 2651 Index, 1 © incicates online material Syndicates video Copyrighted Material ° eo