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Formulation Self Test Questions
Formulation Self Test Questions
1. Briefly discuss advantages and limitations of pharmaceutical aerosol systems.
2. Compare the formulation differences between liquid aerosol, solid aerosol and foam
formulations.
3. Why is aerosol particle size an important factor in formulation of respiratory inhalers?
4. How is particle size controlled in homogeneous and heterogeneous aerosol formulations?
5. In solution aerosol products, a co‐solvent may be present in the liquid phase of the
formulation. Give 2 reasons why.
6. “All in‐all out” formulation principle is important when formulating suspension aerosols.
Explain why.
7. Some formulators suggest that heterogeneous aerosol systems are more problematic than
homogeneous aerosol systems. Comment.
8. Name 2 types of propellant systems commonly used in pharmaceutical aerosols and discuss
their advantages and limitations.
9. Various containers are used for pharmaceutical aerosols. Compare their advantages and
limitations.
10. Discuss the advantages and disadvantages of modified release formulations.
11. Name 3 characteristics a compound to be considered for oral modified release formulation.
12. Using examples and sketches, discuss TWO formulation approaches that can be for oral
controlled release formulations. In your answer, explain how drug release is controlled in
these formulations.
13. Compare the uses, advantages and disadvantages of hydrocarbon vs. absorption ointment
bases.
14. What are major differences in formulation of suppositories and pessaries?
15. Discuss why PEGlyated liposomes may be advantageous in cancer drug targeting. You may
sketch diagram if necessary.