Neurotransmitters

AAs Glutamate, Glycin, GABA, Aspartate

Monoamines NorAdr, Adr, DOPA, Histamine, Serotonine, Melatonin
Amines Phenylthylamine, Tyramine, Octopamine, Tryptamine
Peptides Somatostatin
Purines Adenosine, ATP
Gas CO, NO, H2S
Others ACH

Simpathomimetics
Catecholamines Exogenous Isoproterenol, DOPA, Dobutamine
Endogenous NorAdr, Adr, DOPA

Noncatecholamines Ephedrine, Amphetamine, Phenylephrine, Metoxamina, Metaramiol

Simpatholytics
Nonselective a blocking Ergot, Phenoxibenzamine, Dibenamine, Phentolamine,
Talazoline, Piperaxine, Phenothiazine, Chlorpromazine
Selective A blocking A1 Prazosine, Trimazosine
A2 Atipamazole, Yohimbine
Nonselective B blocking Propanolol, Pronethalol, Sotalol
Selective B blocking B1 Atenolol, Meteprolol
B2 Butoxamine
B3 CGP20712A

Parasympathomimetics
PSM direct acting agents Esters of choline, ACH, Metacoline, Carbacol,
Betanecol
Natural Alkaloids – Cholinomimetics Pilocarpine, Muscarine, Arecoline
PSM indirect acting agents – ACHE inhibitors Phisogtigmine, Neostigmine,
Diisopropilphlorophosphat

Parasimpatholytics
Natural - (Muscarinic antagonists) Atropine, Scopolamine
Synthetic Glycopyrrolate, Homatropine, Methantheline,
Propantheline, Methylatropine
Ganglionic Blocking Agents - ACH competitive Tubocumrine
(Nicotinic antagonists) antagonists
Depolarization Suxamethonium, Hexamethonium
antagonists
 Anaethesia
Preanaesthetic Tranquilizers Acepromazine, Diazepam, Droperidol,
Azaperone
Hypnotics Pentobarbital, Chloral-hydrate
Opioid Morphine, Meperidine
Dissociatives Ketamin
A2 adrenergic agonists Xylazine, Detomidine
Parasympatholytics Atropine, Glycopyrrolate
Anaesthetic Tranquilizers Benzodiazepines
Hypnotics Pentobarbital, Thiopental
Opiod Morphine, Oxymorphine, Fentanyl
Dissociatives Ketamin
Others Guaifenesine, Propofol, Etomidate, Saffan
Postanaesthetic

Anaesthetics
Inhaled Group 1 (Frequent) Halothane, Isofurane, Sevoflurane
Group 2 (New) Desflurane, Xenon
Group 3 (Historical) Ether, Cloroform, Fluroxene, Cyclopropane, Tricycloethylene
Injectable Barbiturics Phenobarbital, Amobarbital, Pentobarbital, Thialbarbital,
Thiopental
Others Propofol, Propanidid, Guaifenesin, Althesin, Etomidate,
Metomidate, Magnesium Sulphate, Ketamin, Tilefamine,
Urethane, Chloralose, Phencyclidine,

Therapeutic Gases
Oxygen Carbon Dioxide

Opioids
Potent full agonists Morphine, Hydromorphone, Oxymorphone, Fentanyl
Medium total agonists Tilidine
Weak total agonists Oxycodone, Codeine, Dihydrocodeine
μ selective agonist Ioperamide
μ partial agonist and kappa antagonist Buprenophine
μ antagonist and kappa agonist Pentazoine, Butorphanol, Nalorphine
Complex mechanism Tramadol
*Antagonist/Antidotes Naloxone, Naltrexone

Endogenous B-endorphins, Enkephalins, Dynorphins

 Tranquilizers
Phenothiazine derivates Chlorpromazine, Promazine, Aceptomazine, Trimeprazine,
Prochlorperazine
Benzodiazepine derivates Diazepam, Midazolam, Clordiazepoid
*Antagonist Flumazenil
Butyrophenone derivates Droperidol, Azaperone
A2 adrenergic agonists Xylazine, Detomidine, Medetomidine, Romifidin
*Antagonist Yohimbin, Talazolin, Atipamezol

Local Anaesthetics
Aminoester Procaine, Chloroprocaine, Tetracaine
Aminoamide Lidocaine, Mepivacaine, Bupvacaine, Ropivacaine

Anticonvulsants
Imepitoina, Potassium Bromide, Phenobarbital, Pentobarbital, Pirimidone, Phengtoin,
Benzodiazepine derivates

Analeptics
Doxapram, Methylxanthine derivates (Theophylline, Theobromine, Caffeine), 4-Aminopyridine,
Talazoline

Drugs affecting animal behaviour

Antipsychotics Chlorpromazine, Promazine, Acepromazine, Haloperidol, Phenothizine
derivates
Anxiolytics Diazepam, Oxacepam, Lorazepam
Antidepressants Tricyclic Antidepressants Imipramine, Clomipramine, Doxepine
MAO Inhibitors Phenelzine
SSRI Fluoxetine, Citaloprame
S and NorAdr RI Venlafaxine

Euthanizing Agents
Gases/Inhaled CO, Co2, N, Inhaled Anaesthetics
Injectable Barbiturics, Chloral-Hydrate, Ethanole, T61
 Autocoids
Histamine Anti-histamines Diphenydramine, Pyrilamine, Tripelenamine,
Clorpheniramine, etc
Serotonin Antagonists GI Smooth Mm. Morphine, Cocaine, Atropine
Smooth Mm. Phenoxybenzamine
Serotonin Cyproheptadine, Reserpine,
Ketanserin, Chlorpromazine
Angiotensin Anti-angiotensin Saralsin, Captopril, Enalapril, Propanolol
Kinins
Prostaglandins A-I
Cytokines TNF-a, Gamma
Interferon, IL

Antiinflammatory Drugs
Traditional Carboxylic Ac. D. Salicyclic Ac. D. Aspirin (Acetylsalicyclic acid)
NSAIDs 1st Gen
Acetic Ac. D. Phenylacetic Ac. Diclofenac,
D. Alclofenac
Carbcyclic Ac. D.Indomethacin,
Ketorolac
Propionic Ac. D Ibuprofen, Naproxen, Ketoprofen
Fenamic Ac. D Toflenamic Acid
Enolic Ac. D. Pyrazolone Phenylbutazone
Oxicams Piroxicam, Lornoxicam
Specific NSAIDs Selective Blockers Meloxicam, Nimesulide
2nd Gen
Specific Blockers Mavacoxib, Celecoxib, Valdecoxib

Natural
Synthetic/PDE Inhibitor
Peripheral Vasodilator
Vasodilator Drugs
Digitoxine, Digoxine, Gitoxine, Gitaline
Nonselective (Amrinone) Xanthine alkaloids
Selective Vinpocetine (1), Papaverine (10), Milrinone (3)
Prazosin, Hydralazine, Captopril, Enalapril

Antiarrhythmic Drugs
Class 1 Sodium Blocking Quinidine, Procalnamide, Lidocaine, Phenyltoin
Class 2 B Blocking Propranolol
Class 3 Potassium Blocking Bretyllum, Amlodarone
Class 4 Calcium Blocking Verapamil
Class 5 Variabe Digoxin, Adenosin, Magnesium Sulphate
 Fluid Therapy
Crystalloid Substances Ringer’s solution, Saline 0,9% , 2,5% Dextrose in saline 0,45%, 5-50%
Dextrose in water
Colloid Substances Synthetic Dextran 40, Dextran 70, Pentastarch, Hetastarch,
Oxypolygelatin
Natural Whole blood, Albumin, Plasma
Hypertonic Solutions

Diuretics
Inhibitors of Carbonic Anhydrase Acetazolamide, Methazolamide, Dichlorphenamide,
Dorzolamide
Osmotic Diuretic Manitol, Glycerin, Urea, Hypertonic Saline
Inhibitors of Sodium transport Furosemide, Ethacrynic Acid, Butmetanidine,
Torsemide
Tiazidine diuretics Water sol: Chlorothiazide, Hydroclorothiazide
Lipo sol: Cyclothiazide, Methylehdothiazide
Inhibitors of renal sodium channels Triamterene, Amiloride
Antagonist of mineralocorticoid receptors Spironolactone, Canrenone
Aquaretics Diuretics Conivaptan, Tolvaptan, Demeclocytine, Litium

Blood Medication
Eritropoyesis Factors Iron, cooper, B6, B2, B9, Vit A, E, C, Nutrients
Antianemic Drugs Acute Hemorrhage Whole Blood, Colloid Solution
Chronic Hemorrhage Whole Blood, Iron Dextran, Nutrition
Hemostatic Drugs Endogenous Clot ADP/ATP, Thromboxane A2, Thrombin,
Thromboplastin, Fibrin, Fibrinogen I,
Serotonin, PGG2, PGH2, Coagulation
Factors I-XIII
Local Thromboplastin, Thrombin, Fibrinogen,
Fibrin, Absorbable gelatine sponge,
Cellulose acid, Microcrystalline
collagen, Adr, NorArd, Topical
hemostatic (silver nitrate, zinc chloride)
Systemic Whole Blood, Vit K, Desmopressin,
Protamine Sulphate, Etamylate
Anticoagulant Endogenous PGI2, Heparin
Lab Sodium Oxalate, Sodium Citrate
Vit. K Antagonists Dicumarol, Warfarin, Phenprocoumon
Fibrinolytics Aminocaproic Acid, Aprotin,
Streptokinase, Fibrinolysin
Antiplatelet Aspirin, Ticlopidase, Dipyridamole

Blood Substitutes
Autotransfusion, Free Hg, PFC, Oxyglobin, Hemerythin
 Hypothyroidism Treatment
Thyroglobulin, T-L3, T-L4

Hyperthyroidism Treatment
Goitrogenes, Thionamides (Carbimazol, Methimazol, Thiouracil, Propilthiouracil, Goitrin

Hypoadrenocorticism
Short Acting <24hrs Hydrocortisone, Cortisone, Prednisone, Prednisolone
Intermediate 24-48hrs Triamcinolone, Isoflupredone
Long >48hrs Flumethazone, Dexamethazone, Betamethazone

Hyperadrenocorticism
Mitotane, Ketazonazole, Deprenyl

Ketosis in cattle
Dextrose 50%, GCT, Insulin

Hypoglycemic Agents
Sulfonylureas, Metformin, Acarbose, Thiazolidinediones

Hyperglycemic Agents
Glucagon, Somatostatin, Diazoxide

Diabetes Insipida
ADH, Desmopresin Acetate, Lysin-8-vasopresine
 Reproductive Drugs
Progestins Syncronize estrus, Inhibit estrus in Progesterone, Altrenogest, Pregestin,
small animals Melengestrol
Gonadotropins Stimulate gonads, anestrus and GnRh, HCG, PMSG, FSH, Gonadorelin,
GnRH overovulation Fertilein Acetate, Burserelin
PGF2a Luteolytic, Induce estrus, interrupt Dinoprost, Tromethamine,
pregnancy/abortion, mummified f. Cloprosternol, Alfaprostol
Estrogen and -Abortifacient (cow), antinidatory -Estradiol
Testosterone and urine incontinence (bitches)
-Teaser cow, shorten calving-estrus
Ergonovine Uterine involution, placental
expulsion
Oxytocin Induce labor (mare), uterine inertia,
agalactic syndrome
Glucocorticoids Parturition (ruminants -> PGF2a ->
decrease progesterone)
Melatonin Advance onset of breeding season
Tocolytics Delay parturition Clenbuterole, Atosibane

Induce lactation in cow

Estradiol, Dexamethazone, Progesterone, Reserpine

Induction of estrus
Sow PMSG + HCG, FSHp + LHp
Mare Burserelin, HCG
Bitch +Cat DES (Diethylstilbestrol) => LH + FSH, PMSG/HCG

Induction of superovulation
Sow PMSG
Cow FSH => PG2a
Goat/Sheep PGF2a => GnRH

Estrus Control - Syncronization

Progesterone (Intravaginal CIDR/PRID), Altrenogest, Pregestin, Melengestrol

Treatment of Ovarian Cysts

Follicular HCG => PGF2a
Luteum PGF2a

Induced Parturition/Abortifacients
Cow PGF2a, Glucocorticoids (Dexamethazone, Flumethazine, Betamethasone), Estradiol
Mare Oxytocin, PGF2a
 Postpartum Medication
Retained placenta Oxytocin
Prevent uterine infection Estrogen
Treat pyometra PGF2a

Antinidatory drugs in small animals

Estradiol

Postponement of estrus in small animals

Megestrol, Chlormadinone, Proligestone, Medroxyprogesterone, Mibolerone, Testosterone

Uterine Inertia
Oxytocin

Cryptorchidism
HCG, Surgery

Prostatic Hypertrophy in dogs

Osaterone Megestrol, Delmadinone, Castration

Pseudopregnancy in dogs
Bromocriptine, Cabergoline, Melergoline

Abortifacients in small animals

PGF2a, Mifepistone, Bromocriptine + Cabergoline + PGF2a, Dexamethazone

Induction of infertility in males

Deslorelin

Urinanary Incontinence
Phenylpropanolamine + Ephedrine, Estriol