Thames Valley Y-Site Intravenous Drugs Compatibility Chart (November 2005)

Prepared by the Thames Valley Critical Care Network Pharmacists Group*

Note:
This table can be used for Y-site compatibility at the usual manufacturers concentrations. You should also ensure that the drugs checked are compatible in terms of carrier fluid
This table gives information for two drug combinations only . It can not be extrapolated to three drug combinations
Use of higher than the manufacturers recommended concentrations (eg in fluid restriction) may affect compatibility
The majority of sources cited define compatibility by physical compatibility rather than chemical compatibility
This table is a guide only. Full information can be obtained from your pharmacy department

Acetylcysteine Key References

Adrenaline 918 Adrenaline 91 Compatible (Reference 1) 1 "Pocket Guide to Injectable Drugs" 11th Edition, Lawrence Trissel, 2001.
Alfentanil 918 918 Alfentanil 21 Incompatible (Reference 1) American Society of Health System Pharmacists (ISBN 1-58528-023-2)
Aminophylline 918 21 918 Aminophylline v1 Variable, contact pharmacy for advice (Reference 1) 2 "King Guide to Parenteral Admixtures: Compatibility of Critical Care Admixtures 2005",
Amiodarone 918 92 918 21 Amiodarone Not Known, do not assume compatibility Patrick Catania, 2005. School of Pharmacy, University of the Pacific (www.kingguide.com)
Aprotinin 918 918 918 918 918 Aprotinin 3 TVCCN Pharmacists Group Consensus
Atracurium 918 91 918 21 92 918 Atracurium 4 Parvolex Injection, ABPI Medicines Compendium 2005, p1840-1841 (ISBN 0-0907102-23-9)
Calcium Chloride 91 92 Calcium Chloride 5 Rapifen Intensive Care, ABPI Medicines Compendium 2005, p2024-2025 (ISBN 0-0907102-23-9)
Calcium Gluconate 91 92 922 93 Calcium Gluconate 6 Cordarone X Intravenous, ABPI Medicines Compendium 2005, p547-548 (ISBN 0-0907102-23-9)
Ciprofloxacin 21 92 91 Ciprofloxacin 7 Tracrium Injection, ABPI Medicines Compendium 2005, p2417-2418 (ISBN 0-0907102-23-9)
Cisatracurium 9 1 9 1 v1 93 92 91 Cisatracurium 8 Nimbex Forte Injection, Nimbex Injection 2mg/ml , ABPI Medicines Compendium 2005, p1699-1703 (ISBN 0-0907102-23-9)
Clonidine 918 918 918 918 918 918 918 Clonidine 9 Catapress Ampoules, ABPI Medicines Compendium 2005, p411-412 (ISBN 0-0907102-23-9)
Compound Sodium Lactate Solution (Hartmann's) 91 95 26 920 97 91 91 91 28 Compound Sodium Lactate Solution (Hartmann's) 10 Dopacard, ABPI Medicines Compendium 2005, p721 (ISBN 0-0907102-23-9)
Disodium Hydrogen Phosphate Disodium Hydrogen Phosphate 11 Xigris, ABPI Medicines Compendium 2005, p2655-2657 (ISBN 0-0907102-23-9)
Dobutamine 918 91 918 21 91 918 91 v1 v1 91 91 918 91 Dobutamine 12 Ventolin Injection, ABPI Medicines Compendium 2005, p2537-2538 (ISBN 0-0907102-23-9)
Dopamine 918 91 918 91 91 918 91 91 91 91 918 91 91 Dopamine 13 Flagyl Injection (100ml), ABPI Medicines Compendium 2005, p935-936 (ISBN 0-0907102-23-9)
Dopexamine 918 918 921 218 921 918 921 921 910 921 918 Dopexamine 14 Losec IV Infusion, ABPI Medicines Compendium 2005, p1403-1404 (ISBN 0-0907102-23-9)
Drotrecogin Alfa (Activated) 217 217 217 917 911 217 217 Drotrecogin Alfa (Activated) 15 Diprivan 1%, Diprivan 2%, ABPI Medicines Compendium 2005, p697-701 (ISBN 0-0907102-23-9)
Esmolol 918 918 918 91 91 918 91 91 91 918 91 92 91 918 Esmolol 16 Ultiva Injection, ABPI Medicines Compendium 2005, p2483-2487 (ISBN 0-0907102-23-9)
Fentanyl 918 91 918 918 92 918 91 92 91 918 91 91 918 91 Fentanyl 17 "Physical and chemical compatibility of drotrecogin alfa (activated) with 34 drugs during simulated Y-site administration"
Furosemide 918 v1 918 91 v1 918 218 91 21 v1 918 91 21 v1 921 217 21 91 Furosemide HY Mann, SL Demmon, DA Boelk et al, Am J Health-Syst Pharm 2004; 61: 2664-2671
Gentamicin 92 91 91 91 91 91 v1 221 217 91 92 v1 Gentamicin 18 "John Farman intensive care unit compatibility chart", Cambridge University Hospitals NHS Foundation Trust,
Glucose 4%, Sodium Chloride 0.18% 91 91 26 920 97 91 91 91 93 93 93 93 93 911 93 93 91 Glucose 4%, Sodium Chloride 0.18% Pharmacy Department, In-house data generated by Brit Cadman and Tim House
Glucose 5% 94 91 95 91 91 920 97 91 91 91 91 99 93 93 91 91 910 911 91 91 91 91 93 Glucose 5% 19 AstraZeneca, Personal communication (16/03/2005)
Glyceryl Trinitrate (GTN) 218 91 218 91 92 218 91 91 218 91 91 91 921 917 92 91 91 91 Glyceryl Trinitrate (GTN) 20 Bayer, Personal communication (16/03/2005)
Heparin (Sodium) 918 91 918 91 21 918 v1 91 21 v1 918 v1 v1 v1 221 217 91 91 91 21 922 922 91 Heparin (Sodium) 21 Zeneus Pharma, Personal communication (22/03/2005)
Insulin (Soluble) 918 918 918 21 91 918 918 918 v1 21 921 217 91 918 918 91 92 92 91 Insulin (Soluble) 22 "Handbook on injectible drugs" 13th Edition, LA Trissel, 2005.
Isosorbide Dinitrate 918 223 223 223 223 918 918 918 923 923 918 918 918 v23 923 218 923 923 Isosorbide Dinitrate American Society of Health System Pharmacists (ISBN 1-58528-107-7)
Labetalol 918 91 918 91 91 918 918 91 918 91 91 91 918 91 91 v1 91 91 91 91 v1 v1 918 Labetalol 23 Schwartz Pharma, Personal communication (22/03/2005)
Magnesium Sulphate v2 22 v1 v1 9 1 91 v1 217 91 91 91 91 91 91 91 Magnesium Sulphate 24 Akzo Nobel, Personal communication (16/03/2005)
Mannitol 91 92 921 v2 92 Mannitol
Metronidazole 92 91 91 91 213 v1 221 217 91 91 91 91 91 Metronidazole
Midazolam 918 91 91 218 91 918 91 91 91 91 918 91 v1 91 918 217 91 91 21 91 93 91 92 91 91 223 91 92 Midazolam
Milrinone 91 92 91 91 91 92 91 91 91 921 91 21 91 91 91 91 91 91 92 91 Milrinone
Morphine 918 91 918 v1 91 918 91 91 91 91 91 91 91 921 91 91 v1 91 91 91 91 v1 91 918 91 91 91 91 91 Morphine
Noradrenaline 918 91 918 21 91 918 918 91 91 91 918 91 91 91 918 217 91 91 v1 93 91 91 91 21 223 91 91 91 91 91 Noradrenaline
Omeprazole 918 218 218 218 218 218 218 218 919 218 218 218 218 218 218 914 218 218 218 218 218 21 218 218 Omeprazole
Potassium Chloride v4 9 1 91 91 91 91 91 91 91 v1 91 921 917 91 91 91 91 91 91 91 91 91 22 91 91 91 91 Potassium Chloride
Potassium Phosphate v1 v1 v1 21 217 91 91 23 Potassium Phosphate
Propofol 91 v15 91 21 22 23 21 21 91 91 91 921 91 91 91 21 91 91 91 91 91 223 91 222 92 v1 9 1 v1 9 1 91 Propofol
Remifentanil 918 91 918 91 918 918 918 91 91 91 918 916 918 91 918 91 91 91 91 916 916 91 91 918 918 918 91 922 91 91 91 91 218 91 916 Remifentanil
Rocuronium 918 924 924 924 918 918 924 924 924 924 924 918 924 924 224 924 924 924 924 924 224 918 924 924 924 924 924 924 924 218 924 924 918 Rocuronium
Salbutamol 912 912 922 924 Salbutamol
Sodium Bicarbonate 21 91 21 222 v1 v1 v1 v1 21 21 210 v1 91 91 91 91 91 21 21 92 21 9 1 v1 21 91 91 91 Sodium Bicarbonate
Sodium Chloride 0.9% 94 91 95 91 26 920 97 922 91 91 91 99 93 93 91 91 910 911 91 91 91 91 93 93 91 922 92 923 91 93 92 93 91 91 91 91 914 91 915 916 924 912 91 Sodium Chloride 0.9%
Sodium Nitroprusside 218 92 918 918 918 918 v1 92 v1 918 92 92 921 217 218 918 918 91 92 91 918 91 92 91 92 92 92 218 92 91 918 924 Sodium Nitroprusside
Thiopental 21 21 v2 21 v1 21 21 21 221 21 v1 21 91 91 91 91 21 21 21 9 1 v1 21 91 91 91 224 v1 9 2 Thiopental
Vancomycin v1 9 1 91 91 91 91 217 91 91 v1 9 1 91 91 91 92 91 91 91 91 224 v1 9 1 Vancomycin
Vasopressin (Arginine Vasopressin) 92 92 92 92 217 92 92 92 92 Vasopressin (Arginine Vasopressin)
Vecuronium 918 91 918 91 92 918 918 918 91 91 91 921 91 91 21 91 91 91 91 918 223 91 91 91 91 91 218 91 924 92 91 22 91 Vecuronium

*Thames Valley Critical Care Network Pharmacists Group

Shakila Bi Wexham Park and Heatherwood Hospitals Jane Hough John Radcliffe Hospital, Dep. Chief P'cists Rep
Mark Borthwick John Radcliffe Hospital, (AICU), Chair (16/01/2004) Claire Humphries Manor Hospital
Jenny Dorey John Radcliffe Hospital, Chief Pharmacists Rep Trevor Jenkins Buckinghamshire Hospitals
Catherine Goddard Royal Berkshire and Battle Hospitals Jill McDonald Milton Keynes General Hospital
Estelle Hames John Radcliffe Hospital, (CTCC) Olivia Moswela Radcliffe Infirmary
Emily Hartwell Horton General Hospital Michelle Taylor-Siddons Stoke Mandeville Hospital

Secretarial support was provided by Sue Gurney

Data Input By: Sue Gurney, Mark Borthwick

Data Verified By: Tara Crews © 2005, Thames Valley Critical Care Network Pharmacists Group
Chart Approved By: Thames Valley Critical Care Network Pharmacists Group, 10 November 2005 Version 1.3