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We leag-aciag Is apPear do he Mere Predictable then intermediate —achag- WP long-acting associated 7h Feuer *Pisodes oP WOpoagiycemia , Particularly Nocturnal hypaglycenea- AW 6%, 0) oles! PF isin lavgine is muailabte in Jiffeeat Remulahion APhers te have longer duration of action , indudinn aconcntntel Zao Usa]. be seheaic od a1 ath less bipegtycemtigee ee = Pi Seed Gone Cortef will ateays Came With righ of hypPeg lycerrra BR Aid 65 ptoderale 4 gpog!y cewtin oe ale! QBS Sweating SRE iors Can trealed b5 OE achy card) an oral Source f @ urge Sugar . GE Naser [Steen ge of q\cte OW vise dhe bleod sg BM sihion of seakncy. EH Sever lypostycentia ¢— Mee abscepenc SyePhes Sal. ag—————— st tsi‘ = WN CEAgies UA BG SO wee bmw £ gicayen IM or SS AemPerur Nn Abra Bed ese BEY is wvaiaiye J the beaten) iy Qe Se wm ADKbese wy Over 1-3 minvhes GaLeew IIA USeArophe, Ahe Sante injechon Sle Ge Milevgie vRNA KA as ais Gag Q- UeKeana @- ‘ash O- argicedenma @-leca) erythenca CERRO. 46 Orn). of ant\wsalin LD 52 ESS OS 9 Bef as es Hus CEN ED syn Fee rey fae CALI He eee5 Tye DZ Drebeles Meth buy + epson 5 CJS 52S 25's! WALES yyper » Sup oo Ol, BP ye Noon Pha cmacelagic 2 0427 © —* ay cow, & _ponPharmacdesi ur . CSE Dios ww 2 = ‘s ; eat ade Role neg Melfernin ke TEX a ae eres ee ae ps) tc pop ames se an F 1 3.5 PS il en cme Ls) cia» albbe Bou) 1 2" ic 3 os Zag oaDe ov JebS G8 pee bee ee ott y Brot ARMS 8 el SM oak (OI ee) oe a, Bes CRBS Ci) ule » ce iiyens ¢ ANS aes i, “sy Se Be foe He aay Cl aie 6! H yiel Gente ca) Biiet SAS elo tl we as dese Ly —Inhilsiter 0 Whe PePhide 4.+ CO -R Oyen wides : a) (35, 5S 21) Coca -@© i es Zp 5ND Pet) Yo - © eee are en Pee camel So as bo we oa) 24 Feerech Wople ty - © He Lt Sikr ti hers bac Sscouraged in Patek OAL — Ven faai lave. = Tonal wr Wedake disease - exemice Red . ; HA odist ¥TFA] rer] ee Sener tig NT te ut el Cree ier eT Ei Pe eth oy ee ry Pewee | Rey DTP pere ery Ree Res) on) Bed ear ene) Renee Rene ese Perl mere Ce area per ireT) BCom pee tn Saree Rite tiene wUme) Pee rey | secretagogues wry ere? || See cries eee Sree ied athe em ocd PLS | pe] ot) FEAL ee ee Beton pee retry ered lk cae Rr ee Bor Rex Inet | en Ree eRe Ces JasSusl,Dipeptidyl Peptidase-4 Ola.» gays JSty ISL lS glall (GLP-1) 1-sezull sacs peptidase-4 (DPP-4) Jered! SW a.szl dbus! 9 4195 6545 J] DPP-4 Slate 6385 ab Sl ol Jasoall 2 gal 559 Olas! ol aSLO9b GLP PubsSy 42 5aSelal Ghazal 3 diazalla dlaas 053 Alogliptin « le 4431 gall cai HbA cby <1% 0 lay4é 20 4283 Losic sitagliptin 9 linagliptin gle ABBlgall Cua yoy alaSg pull Sun SLBSLS 8 lab 20 A595 98 bd pladzuw Saxagliptin (DPP-4 Uae peeSlasiall 1-s.J! glucagon-like DB po 92 Solel Jae 1- seul Slalae Sli 5sdy Lasall 115 “incretin" 49432 999 «GLP-1 slacll ssall LYS LS cya plaball Jolad alexa! GLP-1 Bygsll 8 ABMS] sya) 43 adgll jlgrdl 5 B1g>-gall 538) gadzg « calaudill 38] GLP-1 232 « dagaull Sasall £18] aes ISM sa Lo 8528 JMS ge lSgloJl lguue gle 28] Jiro Sybryull 3 42 atl sajeg 05 GLP-1 Slaao dyls! aii Lasse | SY! 19) j9Sgloull 385 4, Blea! 5 jladay GLP-1 Jac yo 1435 Lgild «abo! Slate yo ySI a> J! HAC yaasd Jalgall 30 TMI aay sre ylizall yo syjall cpus Jo DPP-4 sbsiig Legquul 51519 50 sc 223 Dulaglutide Shee I SBI! 495 Legs 84519 354 liraglutide sc sles! ax. 2 Exenatide S29u8 az -plebll icles! LS ote oho! Bb ye Joludll Ssole 330 gaol Sab Ge odo! al cle! eu yuo Liraglutide 3 89 Sleoll J :Bul y9s besuul (145 8 95920 xt) GLP-1 al semaglutide +19 oo shlve Elaiy! 5 Vleoll all OL Soll (asd Argos! dpcotls KallJSprmegSgle lal ollaze alpha- gti (luS 8 35920 5.) miglitol s Acarbose ean Tee st ot! G8 lee . 4yaall glucosidases jeSolell Sligzue cya solo syd! SLSLI9 Sligzall 9d! LSM yo yuS JSity gial Y Lgl JSUT a2) ol foe ON pall .9 Sul jadi us I Acarbose plus gouty losis pall 8 Sul! yatis sas (yo wai5 (4 B45 UT uns « doud’ll secretagogues ol TID Sley> Gla ld os I] Blo‘l wag! jleul ents 12 slaa HAT C dS29 (alaball Slag 43) yal ple wa cd90t5! Ju ya jo sSull ow vind 22 a lSl yaloky oil! osall gal pall 8 Sul {yaySuull ya Yay S9SoletlLuge uigalull ‘Secretagogues owdousYl Gliclazide «« s.ebs9I5 (SUs) Liss Jigdludl wu JS 3422 tolbutamide ¢ glimepiride « glyburide Laas 6 4e-g)l jArdg gucléll cdgqusll sh 51 at 85S GOMES! 4>-97.41,5 I 1 dues HDATC ansligs9l5) SUs 2 Jol Juaul alassual sd 2WSgll aay Aslostl Yoilas uu dle (tolbutamide 9 SU 3U! Jl 9 Glyburide aslo! Ovclad) Els! (Ae garall ohm 43 65M Jalgall go Ble dale ye 46: pall ugh Seal sad isa 51 ss no saan i ole Ca 695 9h cetsuall 2 yall S58 gl gSay wyoulall go Lega y25I a5 pail Salgall oda yo cl ge wiall Baba pall 8 Sul pads 4515 ..8 Glyburide ¢ i diglaze Oley DUS 8 placa duule 2 cai 935 BEERS day ondall gf cod 088, US II BSLOYL [47] ull FUaS Bapdo SUs sis 48 Boll 950 go axdlad ay 90 Leg TRS LOU yo r5 5 Jal ol Stel sone ghzyallSecretagogues: Meglitinides jw945%! (15 _,8 35920 4) nateglinide » Repaglinide Jas Bylo 2S pol paglladl Slo « tousill j18l jajad le plabll kes 3 Meglitinides i533 31 Gey .SUs 20 SLB I} [g8S> Cong ISU! ay j9Sslill GLeLsI alas HbA1c 3 Repaglinide JI Jas gi g8gzall 30 dal Sl Byolxe LEu} 283 ail US. SUs J Pleo a> VI Say) dogiidall Sleall Glas 23 pall 8 Sul adil Be y> IgSiou yl alabll Glos yololixs yill Syall (lg sa) FPG (diez le dale (d>Loall repaglinide SSLul gl gi 35 49 pliziall aladzuill yo sole 4 Ul pe stew SUs ge Aiylbo JSYI aa) j95lodl le 1S gag Aigo.ll de glly lal gil Le dyleu! Sl 3b J bee ages ohy.sbi J 5,Sodium-Glucose Cotransporter 2 Inhibitors Claes 8 pall 8 Sud! poze GLASIS ge 48 Gol Clby20 (SGLT2) 2 595 slel agusgall .(canagliflozin . dapagliflozin . empagliflozin) 52h2 lao « tals 8 395g! Yolaxel Bale] grad Lgl doll ylsd8 as [50] - Joa! So5glou! 518] B05 J! JoSolel yeas le lgiys89 « SGLT2 Glare go by Sul bya) LadLI 355 Jol gall ells! dliloo 99S 38 le pall bad 5 judo dls! She 51.52 pall (8 ySull padi yo aicia yhasg. 125 8 5518 Aygall yo dzall ode po doMall dsl! US Jats Adgdl Mluall blgdls « dyyladl! dubolial! coasl os slidll pas aisll 3 yaladl LS sisi! 55) Jolgall 060 Gard Gow ..¢ Sud! oxSil ola! lbs Bad yo ygiley gill Wel Jeo tune dy JSizy ySlo «pool! lacus! hd yd yoall ela! of _1SII pall 8 S9Soledl conus 28s SIIGLS word oz ple 87 oeerghtzall oj] Lo¥h