GENERIC CLASSIFICATION DOSAGE
Tramadol Analgesics (Opioid) / Supportive Care M or IV inj (over 2-3 min) or IV infusion
Therapy Moderate to severe pain 50-100 mg 4-6
hrly. Post-op pain Initial dose 100 mg,
followed by 50 mg every 10-20 min. Max:
250 mg in the 1st hr including initial dose.
50-100 mg 4-6 hrly; max 600 mg daily
thereafter.
MECHANISM OF ACTION INDICATIONS ADVERSE REACTION
Tramadol HCl is a cyclohexanol derivative with central Moderate to severe pain & post- Nausea, vomiting, diarrhea, constipation.
analgesic and antitussive activities. Tramadol (and its active op pain. Tiredness, drowsiness, dizziness, headache,
M1 metabolite) acts as an opiate agonist, apparently by confusion, hallucinations. Skin rashes,
selective activity at the mc-receptor. In addition to opiate tachycardia, orthostatic hypotension,
agonist activity, tramadol inhibits reuptake of certain bradycardia, flushing, allergic reactions.
monoamine (norepinephrine, serotonin) which appears to
contribute to its analgesic effect. Unlike morphine, tramadol
has no respiratory depressant effect over a wide range of
analgesic doses. It also does not affect gastrointestinal
motility. Its effects on the cardiovascular system are relatively
slight.